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Preparation method of magnetic stopper

An occluder and magnetic technology, applied in medical science, prosthesis, coating, etc., can solve the problems of weakened cell function, cell shedding, and slow proliferation of endothelial cells, so as to improve endothelialization, improve curative effect, and inhibit inflammatory response and the effect of thrombosis

Inactive Publication Date: 2012-01-11
NO 1 AUXILARY HOSPITAL NO 4 MILLITARY MEDICAL UNIV P L A +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the existing technologies all have the phenomenon of slow proliferation of endothelial cells, weakened cell function and shedding of cells on the surface of the material, failing to significantly solve the problem of endothelialization and prevent the formation of thrombus

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: The existing occluder was ultrasonically cleaned with acetone of analytical grade, absolute ethanol of analytical grade and distilled water for 20 minutes in sequence, and then dried in a vacuum drying oven at 50° C. for 120 minutes.

[0017] The NdFeB alloy was pulverized in a nitrogen protective airflow to prepare NdFeB magnetic particles with a particle size of 3-8 μm, and the Fe / Pd alloy was atomized to prepare Fe / Pd magnetic particles with a particle size of 3-8 μm, and 300 g of NdFeB magnetic particles and 30 g of Fe / Pd magnetic particles were placed in a ball mill tank, and ball milled for 120 minutes to obtain the magnetic particle raw material.

[0018] Under a sterile environment, uniformly mix 80 g of the above-mentioned magnetic particle raw material with 2400 g of polylactide-glycolide carrier to obtain a magnetic raw material.

[0019] Place the treated occluder on the clean operating table, ground it with a wire to make it electrically neutral,...

Embodiment 2

[0021] Example 2: The existing occluder was ultrasonically cleaned with acetone of analytical grade, absolute ethanol of analytical grade and distilled water for 25 minutes in sequence, and then dried in a vacuum drying oven at 70° C. for 90 minutes.

[0022] The NdFeB alloy is pulverized in a nitrogen protective airflow to prepare NdFeB magnetic particles with a particle size of 3-8 μm, and the Fe / Pd alloy is atomized to prepare Fe / Pd magnetic particles with a particle size of 3-8 μm, and 200 g of NdFeB magnetic particles and 200 g of Fe / Pd magnetic particles were placed in a ball mill tank, and ball milled and mixed for 180 minutes to obtain magnetic particle raw materials.

[0023] Under a sterile environment, uniformly mix 60 g of the above-mentioned magnetic particle raw material with 3000 g of polylactide-glycolide carrier to obtain a magnetic raw material.

[0024] Place the treated occluder on the clean operating table, ground it with a wire to make it electrically neu...

Embodiment 3

[0026] Example 3: The existing occluder was ultrasonically cleaned with acetone of analytical grade, absolute ethanol of analytical grade and distilled water for 30 minutes in sequence, and then dried in a vacuum drying oven at 90° C. for 60 minutes.

[0027] The NdFeB alloy was pulverized in a nitrogen protective airflow to prepare NdFeB magnetic particles with a particle size of 3-8 μm, and the Fe / Pd alloy was atomized to prepare Fe / Pd magnetic particles with a particle size of 3-8 μm, and 80 g of NdFeB magnetic particles and 320 g of Fe / Pd magnetic particles were placed in a ball mill tank, and ball milled and mixed for 240 minutes to obtain magnetic particle raw materials.

[0028] Under a sterile environment, uniformly mix 40 g of the above-mentioned magnetic particle raw material with 3200 g of polylactide-glycolide carrier to obtain a magnetic raw material.

[0029] Place the treated occluder on the clean operating table, ground it with a wire to make it electrically ne...

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Abstract

The invention discloses a preparation method of a magnetic stopper, which is used for solving the technical problems of leather chemicals in the traditional stopper. The preparation method of the magnetic stopper comprises the following steps of: preparing a poly (lactide-co-glycolide) biological organic membrane containing magnetic particles on the surface of the traditional stopper, and then endowing the traditional stopper with magnetism on the basis of keeping the biocompatibility of the stopper. Due to the introduction of a magnetic field, the magnetic stopper promotes the adhesion, the migration and the proliferation of endothelial cells, improves the internal leather chemicals of the surface of the stopper and inhibits the inflammatory reaction of vascular walls and the formation of thrombi after being implanted, thereby enhancing the therapeutic effects of interventional therapies of congenital heart diseases.

Description

technical field [0001] The invention relates to a preparation method of an occluder, in particular to a preparation method of a magnetic occluder. Background technique [0002] Interventional occlusion has achieved good results in the clinical treatment of congenital heart disease, but after more than 20 years of application, its shortcomings have gradually been exposed. The most important problem is that the occluder cannot achieve rapid and complete recovery. Endothelialized, with a certain rate of thrombosis. According to reports, under the conditions of interventional occlusion treatment of congenital heart disease and adequate anticoagulation, the occluder generally has a thrombosis rate of 3.6%-7.1%, and some thrombosis rates are even as high as 10%, which seriously affects congenital heart disease. efficacy of interventional therapy. For addressing the above problems, medical workers have proposed multiple solutions. [0003] Document 1 "Prasad C K, Muraleedharan C...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/08A61F2/02
Inventor 胡涛李贺军李寰张磊磊陶凌王海昌
Owner NO 1 AUXILARY HOSPITAL NO 4 MILLITARY MEDICAL UNIV P L A