Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for carrying out treatment on surface of metal bracket by using nitrogen or inert gas

An inert gas, metal stent technology, used in medical science, surgery, etc., to achieve good adhesion firmness, improve cleanliness and adhesion, and smooth surface

Inactive Publication Date: 2010-06-30
万瑞飞鸿(北京)医疗器材有限公司
View PDF0 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The invention solves the traditional problem that only the use of non-degradable materials can ensure the firmness of the stent coating. On the premise of not using non-biodegradable materials such as parylene, the metal stent is cleaned and depyrogenated, and then nitrogen or The inert gas is used for secondary filtration, purification and steady flow, and finally the surface of the stent is treated with nitrogen or inert gas. Specifically, the following technical solutions are adopted:

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A method for treating the surface of a metal support with nitrogen, comprising the following steps:

[0025] 1) Metal bracket preparation:

[0026] ①Surface cleaning: ultrasonically clean the surface of the stent with purified water at an ultrasonic frequency of 20KHZ and a water temperature of 18°C ​​for 30 minutes, then ultrasonically clean the surface of the stent with water for injection at an ultrasonic frequency of 80KHZ and a water temperature of 65°C for 10 minutes.

[0027] ② Depyrogenation treatment: keep the stent at a constant temperature of 180°C for 2.5 hours;

[0028] 2) Preparation of nitrogen:

[0029] ①Perform secondary filtration: first pass nitrogen through a 0.45-micron filter device, and then pass through a 0.1-micron filter device for purification.

[0030] ②Input the purified nitrogen into the gas source device of the ultrasonic atomizing sprayer, adjust the injection pressure of the gas source device to 0.1 bar, the gas flow rate to 1.0 ml / s, ...

Embodiment 2

[0033] A method for treating the surface of a metal support with helium, comprising the following steps:

[0034] 1) Metal bracket preparation:

[0035] ①Surface cleaning: Ultrasonic cleaning the surface of the stent with purified water, ultrasonic frequency 80KHZ, water temperature 65 ℃, cleaning for 10 minutes, and then the surface of the stent was ultrasonic cleaning with water for injection, ultrasonic frequency 20KHZ, water temperature 18 ℃, cleaning for 20 minutes,

[0036] ② Perform depyrogenation treatment: keep the stent at a constant temperature of 250°C for 2 hours;

[0037] 2) Preparation of helium:

[0038] ①Perform secondary filtration: first pass helium through a 0.65-micron filter device, and then pass through a 0.22-micron filter device for purification.

[0039] ②Input the purified helium into the gas source device of the ultrasonic atomizing sprayer, adjust the injection pressure of the gas source device to 0.15 bar, and the gas flow rate to 1.5 ml / s, and ...

Embodiment 3

[0042] A method for treating the surface of a metal support with neon gas, comprising the following steps:

[0043] 1) Metal bracket preparation:

[0044] ①Surface cleaning: ultrasonically clean the surface of the stent with purified water at an ultrasonic frequency of 20KHZ and a water temperature of 18°C ​​for 30 minutes, then ultrasonically clean the surface of the stent with water for injection at an ultrasonic frequency of 20KHZ and a water temperature of 18°C wash for 20 minutes,

[0045] ② Depyrogenation treatment: keep the stent at a constant temperature of 250°C for 2.4 hours;

[0046] 2) Preparation of neon gas:

[0047] ① Carry out secondary filtration: first pass the neon gas through a 0.5 micron filter device, and then pass through a 0.15 micron filter device for purification.

[0048]②Input the purified neon gas into the gas source device of the ultrasonic atomizing sprayer, adjust the injection pressure of the gas source device to 0.1 bar, and the gas flow ra...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for carrying out treatment on the surface of a metal bracket by using nitrogen or inert gas. The method comprises the following steps: in the process of preparing a drug-eluting stent, carrying out treatment of cleaning and depyrogenation on the metal bracket, carrying out secondary filtration, purification and flow stabilization, and finally carrying out treatment on the surface of the stent by using the nitrogen or inert gas. The method carries out treatment of inert gas on the surface of the metal stent under the premise of adopting a completely-degradable coating, thus improving the adhesion firmness of the drug coating and the surface of the stent and simultaneously also effectively guaranteeing the uniformity of the drug coating. The drug stent has smooth surface and good adhesion firmness, thus improving the safety and effectiveness of clinical use of the drug stent.

Description

technical field [0001] The invention relates to a method for treating the surface of a metal stent with nitrogen or an inert gas, in particular to a method for treating the surface of a metal stent with nitrogen or an inert gas used in preparing a drug-eluting stent. Background technique [0002] Coronary artery stent implantation is a minimally invasive interventional treatment technology for coronary heart disease that appeared in the mid-1980s and developed rapidly in the past five years. This technology is guided and monitored by X-ray equipment. Auxiliary devices such as sheath, angiography guide wire, angiography catheter, guide wire, guide catheter, balloon dilation catheter, etc., finally deliver the drug-eluting stent to the stenosis position in the coronary artery, and pressurize and expand the stent delivery system The metal stent with a grid structure enables the stent to support the narrowed diseased artery, thereby achieving the therapeutic purpose of restoring...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61L31/02A61L31/16A61L31/14
Inventor 田飞王昊飞王海军
Owner 万瑞飞鸿(北京)医疗器材有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com