The present invention relates to the field of ink technology, in particular to a UV screen printing plastic ink and a preparation method thereof. The UV screen printing plastic ink of the present invention consists of the following raw materials in parts by weight: 18-28 parts of polyurethane acrylate, 16-25 parts of polyester Acrylate, 6~15 parts of solid acrylic resin, 2~8 parts of TPGDA, 7~15 parts of TMPTA, 4~12 parts of HDDA, 14~22 parts of pigment powder, 1~3 parts of dispersant, 0.2~1.2 parts of silicone disinfectant Foaming agent, 1~4 parts of silicone leveling agent, 1~3 parts of photoinitiator, 0.2~1.5 parts of adhesion promoter. The present invention uses solid acrylic resin as one of the base materials, which has better flexibility and adhesion, greatly improves the printing adaptability of plastic inks, and the base materials urethane acrylate and polyester acrylate have excellent adhesion, The adhesion firmness of the present invention is further enhanced, the printing adaptability is better, and the printing effect is good.