Method for preparing hydroxyethyl starch

A technology of hydroxyethyl starch and hydroxyethylation, applied in blood diseases, extracellular fluid diseases, drug combinations, etc., can solve the problems of reducing product quality, cumbersome preparation process, difficult control of starch molecular weight, etc., to avoid damage Effect
CN101775076AInactive Publication Date: 2010-07-14CHENGDU QINGSHAN LIKANG PHARMA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
CHENGDU QINGSHAN LIKANG PHARMA CO LTD
Publication Date
2010-07-14
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for preparing hydroxyethyl starch. The starch raw materials are subjected to hydroxyethylation and acid hydrolysis treatment in a solvent medium respectively. The method for preparing the hydroxyethyl starch comprises the following steps: firstly, under the alkaline condition that the pH is 13-14, carrying out hydroxyethylation reaction by using ethylene oxide or chlorethanol in an amount which is 0.2 to 1.8 times mol of the starch as a hydroxyethylation reagent; secondly, hydrolyzing the starch raw materials which are subjected to the hydroxyethylation under the acidic condition that the pH is 1-3 to obtain the hydroxyethylation starch, wherein the weight-average molecular weight is 20 to 500kD; the molar degree of substitution is 0.1 to 0.9, and the substituted ratio at the C2 / C6 position is 3 to 20 and the substituted ratio at the C3 / C6 position is 0.1 to 8. The method for preparing the hydroxyethyl starch can prevent the starch structure from being damaged without pasting the starch, solve the problems that the control of the molecular weight of the products is inaccurate during acid hydrolysis, an organic residual solvent which is subjected to the hydroxyethylation is hardly removed and the like, and is favorable for industrialized production. Therefore, hydroxyethylation starch products with different molecular weights and / or degrees of substitution can be obtained.
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Description

technical field

[0001] The invention relates to a preparation method of hydroxyethyl starch. Background technique

[0002] Hydroxyethyl starch (HES) is used for blood volume expansion in clinical treatment and has become an irreplaceable plasma substitute.

[0003] The physiological and chemical properties of hydroxyethyl starch are mainly determined by parameters such as weight average molecular weight (Mw), degree of substitution (Ms) and substitution mode. For example: the clinical effect is confirmed, hydroxyethyl starch 200 / 0.5 (that is, the weight average molecular weight is 200kD, the average molar substitution degree of glucose residue is 0.5 (allowable range 0.43 ~ 0.55), and the substitution ratio of C2 / C6 position is 5: 1) The expansion effect can reach 100%, the expansion time is 4-8 hours, the half-life is 3-4 hours, the allergic reaction is low, and it has the function of preventing and blocking capillary leakage. It can also reduce the release of vasoactive ...

Claims

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