Preparation process of 68Ge line source used for PET attenuation correction
A preparation process and attenuation correction technology, which is applied in the field of nuclear medicine imaging, can solve the problems of affecting the quality of imaging correction, changes in dose distribution, poor radiation resistance, etc., and achieve good linear uniformity, easy filling, and convenient procurement Effect
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Embodiment 1
[0017] Concrete preparation process is as follows:
[0018] This embodiment mainly adopts two steps to complete the preparation.
[0019] first step 68 Adsorption of Ge. The concentration of nitric acid solution, the concentration of Ge ions and the selection of oscillation adsorption time in the process play a key role in improving the utilization rate of Ge ions, the adsorption rate and the uniformity of adsorption. In this embodiment, 10 ml of nitric acid solution with a concentration of 15 mol / L and 1 ml of germanium chloride solution with a concentration of 25 mg / ml are mixed, and then 0.1 ml of carrier-free chlorine [ 68 Ge] germanium solution, configured as a mixed system. The concentration of nitric acid solution in the mixed system is 13.6mol / L, and the concentration of Ge ions is 2.3mg / ml. Put 3g of ceramic microspheres with a particle size of 100-200 mesh into the mixing system, and react for 15 minutes under shaking conditions to fully absorb the ceramic micros...
Embodiment 2
[0024] The present embodiment is the same as Example 1, and its difference is that in the first step, the nitric acid solution adopts 10ml concentration to be 15mol / L and 2.5ml concentration to mix the germanium chloride solution that is 25mg / ml, and the nitric acid in the mixed solution that is configured The concentration is 12 mol / L, and the concentration of Ge ions is 5 mg / ml. Add ceramic microspheres with a particle size of 100 to 200 mesh into the mixing system, shake and react for 20 minutes, and wash the ceramic microspheres with 12mol / L nitric acid, 1mol / L nitric acid, water, and acetone in sequence. According to the formula, The adsorption efficiency of this example is
Embodiment 3
[0026] The present embodiment is the same as Example 1, and its difference is that in the first step, the nitric acid solution is mixed with 10ml concentration of 15mol / L and 0.2ml concentration of germanium chloride solution of 25mg / ml, and the concentration of nitric acid in the mixed solution is configured The concentration is 15 mol / L, and the concentration of Ge ions is 0.5 mg / ml. Add ceramic microspheres with a particle size of 100-200 mesh into the mixing system, shake and react for 10 minutes, and wash the ceramic microspheres with 15mol / L nitric acid, 1mol / L nitric acid, water, and acetone in sequence. According to the formula, The adsorption efficiency of this embodiment is 90%.
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