Application of nutrition combination in preparation of medicine for promoting proliferation of liver stem cells

A nutritional composition and technology of liver stem cells, applied in the direction of drug combinations, pharmaceutical formulas, plant raw materials, etc., can solve the problems of no records, etc., and achieve the effect of promoting the proliferation of adult liver stem cells without immune rejection

Active Publication Date: 2010-07-21
珍奥集团股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the patent application document does not record that the nutritional

Method used

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  • Application of nutrition combination in preparation of medicine for promoting proliferation of liver stem cells
  • Application of nutrition combination in preparation of medicine for promoting proliferation of liver stem cells
  • Application of nutrition combination in preparation of medicine for promoting proliferation of liver stem cells

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Experimental program
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Embodiment Construction

[0012] 1. Establish model, experiment grouping and experiment process

[0013] Establishment of aplastic anemia mouse model: BALB / c mice were used in this experiment. Experimental procedure: Acetylhydrazine 100mg / kg was injected subcutaneously on day 1, X-ray 2.0Gy was irradiated on the next day, cyclophosphamide 80mg / kg was injected intraperitoneally on day 5, and the above steps were repeated on day 15 without radiation treatment. The normal control group was injected with the same amount of normal saline at the corresponding site.

[0014] Experimental grouping: According to the drug dosage of animal pharmacology and the design and analysis of comprehensive experiments, it is divided into: ① normal control group; ② aplastic anemia model group; ③ high dose group, with 1445.55mg / kg. Rats were given intragastric administration; ④ medium dose group, 963.7 mg / kg.d nutritional composition was administered to aplastic mice; ⑤ low dose group, 674.59 mg / kg.d nutritional composition...

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Abstract

The invention discloses application of nutrition combination in the preparation of a medicine for promoting the proliferation of liver stem cells. The nutrition combination can promote the proliferation of hemopoietic stem cells and the synthesis of hemoglobin, can provide conditions for awakening dormant adult liver stem cells and can further promote the proliferation of the adult liver stem cells. The invention solves all kinds of problems existing in the existing orthotopic liver transplantation and the donator liver stem cell transplantation, and has the advantages of high effectiveness, high safety, great convenience, economy, no immunological rejection and the like.

Description

Technical field: [0001] The invention relates to the use of a nutritional composition, in particular to the application of a nutritional composition in the preparation of drugs for promoting the proliferation of liver stem cells. Background technique: [0002] Many refractory liver diseases such as chronic hepatitis, liver fibrosis and cirrhosis, portal hypertension, primary liver cancer, hereditary and metabolic liver diseases are thorny problems faced by the whole world. Orthotopic liver transplantation is currently the only effective treatment for end-stage liver failure caused by the above-mentioned reasons. However, due to the extreme shortage of liver donors, the high mortality rate associated with surgery and transplantation itself, the life-long administration of immunosuppressants and the serious or even fatal complications, the widespread clinical application of liver transplantation is greatly limited. [0003] With the continuous development of stem cell biology...

Claims

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Application Information

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IPC IPC(8): A61K36/87A61P1/16A61K33/26A61K33/30A61K33/32A61K31/714A61K31/525A61K31/4415A61K31/519A61K31/375A61K31/355A61K31/715A61K31/685A61K31/7052A61K31/198A61K31/4172
Inventor 吴文国李恕董锋
Owner 珍奥集团股份有限公司
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