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Oral spraying agent prepared from traditional Chinese medicine and preparation method thereof

A technology of oral spray and traditional Chinese medicine, which is applied in the directions of medical formula, aerosol delivery, drug combination, etc., can solve the problems that the development of new antibiotics and chemical drugs cannot meet the market demand, bacterial drug resistance, high price, etc., and achieve Expand the range of drug action, treat oral ulcers, and prevent dental caries

Inactive Publication Date: 2010-08-11
NORTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing oral sprays on the market contain complex and expensive ingredients. Most of them contain antibiotics, which are easy to cause bacterial resistance, and the bacterial drug resistance rate and bacterial detection rate are increasing year by year. New antibiotics and The development of chemical drugs is far from meeting the needs of the market

Method used

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  • Oral spraying agent prepared from traditional Chinese medicine and preparation method thereof
  • Oral spraying agent prepared from traditional Chinese medicine and preparation method thereof
  • Oral spraying agent prepared from traditional Chinese medicine and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 5

[0028] Example 1 The optimal extraction method of the active ingredient of Galla chinensis Coptidis extract

[0029] According to the extraction method and formulation requirements of traditional decoctions, ethanol content in the extract, ultrasonic treatment time, and the mass ratio of Chinese gallbladder and Rhizoma Coptidis were selected as the investigation factors, and the amount of dry sediment was used as the investigation index. 9 (3) 4 Orthogonal table to test.

[0030] Table 1 Factor level table

[0031]

[0032] The intuitive analysis and variance analysis of the test results show that the factor that has the greatest influence on the extraction of active ingredients is the ethanol content, and the best process is A 1 B 2 C 1 , that is, the ethanol content is 50%, ultrasonic treatment is 20min, and the mass ratio of Chinese gallnut and Coptis chinensis is 1:8.

[0033] Tween-80 / glycerin / gum arabic / gelatin and Span-80 have the best effect at a ratio of 1:1. ...

Embodiment 2

[0035] A kind of oral spray, its composition and parts by weight are:

[0036] Chinese Gallnut Coptidis Extract 20 parts

[0037] Tween-80 20 servings

[0038] Span-80 20 servings

[0039] 70 servings of simple syrup

[0040] Purified water 862 parts

[0041] preservative 3 servings

[0042] Fruit flavor 5 parts

[0043] The extraction process of the above-mentioned Galla chinensis Coptis chinensis extract is as follows: Galla chinensis and Coptis chinensis medicinal materials are pulverized respectively, passed through an 80-mesh sieve, the mass ratio of the two is 1:8, and ultrasonically extracted three times with ethanol solution with a volume ratio of 50%, each time for 20 minutes. The liquid ratio is 1:10. The two extracts were mixed, filtered, and dried in an oven below 60°C for 12 hours.

Embodiment 3 5

[0044] The low-inhibition performance of embodiment 3 Chinese Gallnut Rhizoma Coptidis Extract

[0045] To determine the minimum inhibitory concentration of the extract of Coptis chinensis, DMF (N, N-dimethylformamide) was used as a solvent to prepare a concentration gradient.

[0046] 1. Time and test conditions

[0047] In June 2009, in the Bacteriology Room of the Laboratory Department of Shaanxi Provincial People's Hospital.

[0048] 2. Strains

[0049] The Bacteria Laboratory of the Laboratory Department of Shaanxi Provincial People's Hospital provided a clinical Staphylococcus epidermidis strain, and 4 standard strains were purchased from the Beijing Institute of Biology, including Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus albus.

[0050] 3. Test and result evaluation method

[0051] Sensitive strains were screened by drug susceptibility test, and K-B agar diffusion method was used. The reference standard for the drug suscepti...

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Abstract

The invention relates to a spraying agent prepared from a traditional Chinese medicine for inhibiting oral bacteria, treating dental ulcer and preventing and treating dental caries, which comprises the components in parts by weight: 10-20 parts of gallnut and coptis extract, 10-20 parts of tween-80 / glycerol / acacia / gelatin, 10-20 parts of span-80, 60-70 parts of simple syrup and 800-900 parts of purified water. The gallnut and coptis extract has the following extracting steps: crushing gallnut and coptis and then passing through a sieve with 80 meshes, wherein the mass ratio of the gallnut to the coptis is (1:6)-(1:12); extracting with ethanol solution with the volume ratio of 40-80 percent; and filtering and drying the extracted filtrate. The invention has the advantages of simple preparation method, convenient use, pure traditional Chinese medicine, no addition of any antibiotic and no generation of bacterial drug resistance; and in addition, the invention can be directly used for mucosa inside an oral cavity as well as used for inhibiting oral bacteria, treating the dental ulcer and preventing and treating dental caries.

Description

technical field [0001] The invention relates to a traditional Chinese medicine spray for inhibiting oral bacteria, treating oral ulcers and preventing dental caries and a preparation method thereof. Background technique [0002] The human oral cavity contains a large number of bacteria, such as Streptococcus, Staphylococcus, Pseudomonas aeruginosa, Escherichia coli and so on. When the balance of these flora is broken, it will cause a variety of oral diseases, such as oral ulcers, dental caries, etc., seriously affecting people's health. [0003] Oral ulcer, also known as Recurrent Oral Ulcer (ROU), is a relatively common oral mucosal disease. Its causes are complex and have not been fully elucidated. Most of them are caused by bacterial or viral infections. Oral ulcers have a high incidence rate and are very easy to relapse. There is severe pain during the attack, which affects eating and speaking, and brings great pain and inconvenience to the patient, especially when enco...

Claims

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Application Information

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IPC IPC(8): A61K36/718A61K9/12A61P1/02A61K35/64
Inventor 鲁海燕张龙冯索民孙文基
Owner NORTHWEST UNIV
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