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Pills taking salbutamol sulfate and ambroxol hydrochloride as main active ingredients and preparation method thereof

A technology of ambroxol hydrochloride dripping pills and salbutamol sulfate, which is applied in the direction of non-active ingredients of polymer compounds, pill delivery, respiratory diseases, etc., and can solve the problems of low bioavailability of oral preparations

Inactive Publication Date: 2010-08-25
北京利乐生制药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Pharmacokinetic studies have proved that it metabolizes rapidly in the body, excretes quickly, and has low bioavailability of oral preparations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] prescription:

[0023] Salbutamol Sulfate 1g

[0024] Ambroxol Hydrochloride 15g

[0025] PEG400 34g

[0026] PEG6000 150g

[0027] A total of 1000 capsules were made

[0028] Preparation:

[0029] Take albuterol sulfate, ambroxol hydrochloride, PEG400, PEG6000 and mix evenly, heat in a water bath to melt completely to obtain a molten liquid; then pour the molten liquid into the material funnel of the dripping pill making machine, keep it warm at 80°C, and select the droppings Head, drop into simethicone oil at -5°C, after forming, filter, separate, wipe clean, that is to say.

Embodiment 2

[0031] prescription:

[0032] Salbutamol Sulfate 1g

[0033] Ambroxol Hydrochloride 15g

[0034] PEG6000 150g

[0035] Polyoxyl 40 stearate 34g.

[0036] A total of 1000 capsules were made

[0037] Preparation:

[0038] Take albuterol sulfate, ambroxol hydrochloride, PEG6000, and polyoxyl 40 stearate and mix evenly, heat in a water bath to completely melt to obtain a molten liquid; then pour the molten liquid into the material funnel of the dropping pill dropping machine, Keep warm at 80°C, select the dripper, drop into the simethicone oil at -10°C, after forming, filter, separate, wipe clean, and the product is ready.

Embodiment 3

[0040] prescription:

[0041] Salbutamol Sulfate 0.5g

[0042] Ambroxol Hydrochloride 7.5g

[0043] PEG6000 62g

[0044] PEG4000 80g.

[0045] A total of 1000 capsules were made

[0046] Preparation:

[0047] Take albuterol sulfate, ambroxol hydrochloride, and polyoxyl 40 stearate, mix evenly, heat in a water bath to melt completely, and obtain a molten liquid; then pour the molten liquid into the material funnel of the dropping pill dropping machine, at 80°C Keep warm, select the dripper, drop it into the liquid paraffin at -5°C, after it is formed, filter, separate, and wipe it clean.

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PUM

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Abstract

The invention relates to pills taking salbutamol sulfate and ambroxol hydrochloride as main active ingredients and a preparation method thereof, and aims to provide a new preparation, namely salbutamol sulfate and ambroxol hydrochloride pills, for the vast number of patients and medical workers. The preparation can improve the bioavailability of medicaments, give full play to the treatment effects of the medicaments and reduce adverse reactions, is convenient for children to swallow and for old people to take with reduced dosage, and is convenient to carry, store and transport. The preparation method is simple and suitable for mass production. In the method, the pills are prepared by adding some specific types of auxiliary materials in certain proportions into the salbutamol sulfate and ambroxol hydrochloride serving as the active ingredients according to the conventional technique of pharmaceutical engineering.

Description

technical field [0001] A drop pill with albuterol sulfate and ambroxol hydrochloride as main active ingredients and a preparation method thereof. The invention relates to a novel pharmaceutical preparation, in particular to salbutamol sulfate and ambroxol hydrochloride dripping pills for respiratory diseases and a preparation method thereof. Background technique [0002] Respiratory system disease is a common and frequently-occurring disease that endangers people's health, and its incidence rate accounts for the first among many diseases in any age group. According to data from the Statistical Yearbook of the United States, among all causes of death, the cause of death related to respiratory diseases (excluding tumors) rose from the 10th in 1970 to the 4th in 1991 (chronic obstructive pulmonary disease). and No. 8 (pneumonia, influenza and upper respiratory tract infection). The British Society for Thoracic Surgery pointed out in a recent research report that respiratory d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/137A61K47/40A61K47/34A61P11/00A61P11/06A61K47/10A61K47/14A61K47/42
Inventor 李宝齐
Owner 北京利乐生制药科技有限公司
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