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Composite nanometer emulsion containing borneol and alum and preparation method thereof

A technology of nanoemulsion and alum, which is applied in the direction of drug combination, emulsion delivery, active ingredients of aluminum/calcium/magnesium, etc. It can solve the problems of easy crystallization and precipitation of borneol, achieve good surface activity, improve solubility, and uniform dispersion

Inactive Publication Date: 2010-08-25
HUNAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] For the deficiencies and defects that existing alum ice liquid exists, especially the problem that borneol is easy to crystallize and separate out, the object of the invention is to provide a kind of composite nanoemulsion containing borneol, alum and preparation method thereof, to make uniformly dispersed, transparent ( or translucent), stable alum ice nanoemulsion

Method used

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  • Composite nanometer emulsion containing borneol and alum and preparation method thereof
  • Composite nanometer emulsion containing borneol and alum and preparation method thereof
  • Composite nanometer emulsion containing borneol and alum and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0018] Take 2.5g of borneol, grind it finely, add 6g of ethyl oleate, stir to dissolve, then add 16g of polyoxyethylene octylphenyl ether (OP-10) to it, stir and mix well, then slowly add distilled water to it, Stir while adding. At the beginning, with the increase of water volume, the system becomes viscous and gelatinous. When adding distilled water to a certain amount, the solution becomes thinner and becomes transparent to translucent with light blue opalescence. Take another 13.8g of alum and 9g of sodium chloride, dissolve it in an appropriate amount of distilled water, filter, and slowly add the filtrate to the above solution containing borneol, etc., and add distilled water to 1000ml, stir and mix, filter, potting and sealing in Put it in a 100ml infusion bottle, and sterilize it at 115.5°C for 30 minutes.

Embodiment 2

[0020] Take 1.25g of borneol, grind it finely, add 3g of ethyl oleate, stir to dissolve, then add 8g of polyoxyethylene octylphenyl ether (OP-10) to it, stir and mix well, then slowly add distilled water to it, While adding and stirring, the system becomes viscous and gelatinous at the beginning as the amount of water increases, and when distilled water is added to a certain amount, the solution becomes thinner and becomes transparent to translucent with light blue opalescence. Take another 6.9g of alum, 9g of sodium chloride, dissolve in appropriate amount of distilled water, filter, slowly add the filtrate to the above solution containing borneol, etc., and add distilled water to 1000ml, stir and mix, filter, potting and sealing in Put it in a 100ml infusion bottle, and sterilize it at 115.5°C for 30 minutes.

Embodiment 3

[0022] Take 12.5g of borneol, grind it finely, add 30g of ethyl oleate, stir to dissolve, then add 80g of polyoxyethylene octylphenyl ether (OP-10) to it, stir and mix well, then slowly add distilled water to it, While adding and stirring, the system becomes viscous and gelatinous at the beginning as the amount of water increases, and when distilled water is added to a certain amount, the solution becomes thinner and becomes transparent to translucent with light blue opalescence. Take another 69g of alum and 9g of sodium chloride, dissolve in an appropriate amount of distilled water, filter, and slowly add the filtrate to the above solution containing borneol, etc., and add distilled water to 1000ml, stir and mix, filter, potting and sealing in 100ml In the infusion bottle, sterilize at 115.5°C for 30 minutes to obtain.

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Abstract

The invention relates to a composite containing borneol and alum. The composite can be prepared into an external traditional Chinese medicine preparation for diseases such as empyrosis, allergic skin diseases, surgical wound infection, chemical drug-induced phlebitis, radiodermatitis, and the like. Each 100 ml of emulsion of the composite nanometer emulsion containing borneol and alum comprises 0.125 g to 2.5 g of borneol, 0.69 g to 6.9 g of alum, 0.3 g to 3 g of oil for injection, 0.8 g to 8 g of emulsifier, 0.1 g to 1.5 g of sodium chloride and the balance of distilled water or water for injection, and the particle size range is from 1 to 100 nanometers.

Description

technical field [0001] The invention relates to a composition containing borneol and alum. It can be prepared as an external Chinese medicine preparation for diseases such as burn (scald) injury, allergic skin disease, surgical wound infection, chemical drug phlebitis, radiation dermatitis and the like. Background technique [0002] Alum ice liquid is a preparation in the First Affiliated Hospital of Hunan University of Traditional Chinese Medicine (refer to the comparative document Liu Lifang "Chinese Medicine Emergency" 2002 vol11(6), p448), which is prepared from the two-flavored traditional Chinese medicine prescription of alum and borneol, and the drug composition is 14g of alum , borneol 2.8g. First take alum and grind it into fine powder, add appropriate amount of water, heat to dissolve, add 9g of sodium chloride to dissolve, and then filter; take another borneol, grind it into fine powder, mix with 7ml of polysorbate-80 solution, add to the above filtrate, add wate...

Claims

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Application Information

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IPC IPC(8): A61K33/06A61K9/10A61P17/02A61K31/045
Inventor 刘丽芳夏新华杨平张冀莎欧阳荣周青
Owner HUNAN UNIV OF CHINESE MEDICINE
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