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Method for preparing L-arginine nitrate

A technology of arginine and nitrate, which is applied in the field of preparation of L-arginine nitrate and achieves the effects of less impurities, improved yield and good quality

Active Publication Date: 2012-11-07
TIANJIN TIANCHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no industrialized production of L-arginine nitrate in the world at present.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Pour 16 kg of purified water into the reaction vessel, then add 8 kg of L-arginine, stir well, then slowly add 5.4 kg of 65% nitric acid, and stir while adding nitric acid to make it evenly mixed. After adding nitric acid, the solution was heated to 55°C±5°C, and the solution gradually became clear as the temperature increased. Measure the pH before the end of the reaction, and adjust the pH of the solution to 2 with nitric acid. After the solution is completely clarified, cool to 20°C ± 2°C to crystallize, use a centrifuge to separate the L-arginine nitrate crystals from the mother liquor, dry the crystals, and use absolute ethanol with 10-20% weight of the crystals after drying Rinse the crystals, spin dry and dry at 80°C to obtain the finished product of L-arginine nitrate. The yield is about 40%. The mother liquor continues to be recycled repeatedly.

Embodiment 2

[0027] Add 8 kilograms of L-arginine in the about 16 kilograms of mother liquors that embodiment 1 produces, add 5.4 kilograms of 65% nitric acid after stirring, stir while adding nitric acid, make it mix homogeneously. After adding nitric acid, the solution is heated to 45°C±5°C, and the solution gradually becomes clear as the temperature rises. Measure the pH before the end of the reaction, and adjust the pH of the solution to 2 with nitric acid. After the solution is completely clarified, cool to 15°C±2°C to crystallize, use a centrifuge to separate the L-arginine nitrate crystals from the mother liquor, and dry the crystals; Rinse the crystals with ethanol, spin dry and dry at 80°C to obtain the finished product of L-arginine nitrate. The yield is nearly 100%. The mother liquor continues to be recycled repeatedly.

Embodiment 3

[0029]Add 8 kilograms of arginine in the about 16 kilograms of mother liquors that produce in embodiment 2 production, add 5.4 kilograms of 65% nitric acid after stirring, stir while adding nitric acid, make it mix homogeneously. Control the nitric acid addition rate so that the temperature of the solution gradually reaches 40°C without external heating, and the solution gradually becomes clear with stirring. Measure the pH before the end of the reaction, and adjust the pH of the solution to 2 with nitric acid. After the solution is completely clarified, cool to 12°C±2°C to crystallize, use a centrifuge to separate the L-arginine nitrate crystals from the mother liquor, and dry the crystals; use absolute ethanol with 10-20% weight of the crystals after drying Rinse the crystals, spin and dry at 80°C to obtain the finished product of L-arginine nitrate. The yield is nearly 100%. The mother liquor continues to be recycled repeatedly.

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PUM

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Abstract

The invention discloses a method for preparing L-arginine nitrate. The method comprises the following steps of: adding L-arginine to purified water at normal temperature, uniformly mixing and slowly adding nitric acid; leading the mole ratio of L-arginine to nitric acid to be 1:1-1.1 and the weight ratio of L-arginine to purified water to be 1:2; leading reaction temperature to range from 40 DEG C to 70 DEGC, gradually clarifying solution, adjusting the pH value to 1-2 by using nitric acid, cooling the clarified solution until the temperature thereof ranges from 10 DEG C to 25 DEG C, and carrying out solid-liquid separation on separated crystal; flushing and drying the crystals at the temperature from 60 DEG C to 85 DEGC to obtain the arginine nitrate finished product; and continuously recycling the liquor obtained after solid-liquid separation and used as mother liquor. The L-arginine is adopted to react with the nitric acid under moderate reaction conditions. The production process is reasonable and simple, and industrialized large-scale production can be achieved. The L-arginine nitrate prepared by the method has good quality, more than 99 percent of purity, continuous cyclic use of mother liquor generated during preparation and more than 98 percent of yield coefficient of the product.

Description

technical field [0001] The invention belongs to a preparation method of guanidine derivatives, in particular to a preparation method of L-arginine nitrate with good product quality, high yield and low cost. Background technique [0002] Amino acids are the basic substances that make up the protein needed for animal nutrition. Generally, people can produce various amino acids to meet the body's needs through their own production or through food. However, in special cases such as illness, injury or heavy exercise, in order to restore the balance of various metabolisms in the body, enhance immunity and athletes recover physical strength as soon as possible, and increase muscle strength, it is necessary to supplement various amino acids. [0003] L-arginine is a kind of amino acid, the chemical name is L-2-amino-5-guanidine pentanoic acid, it is a semi-essential binary amino acid for human beings. However, the production rate in the body is slow, and it is an essential amino a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C279/14C07C277/08
Inventor 张国基
Owner TIANJIN TIANCHENG PHARMA