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Cornutcd pugionium extractive and application thereof

A technology of extract and mustard, applied to the extract of mustard and its application field, can solve the problems of allergic purpura, liver damage, prolongation of cardiac QT interval, etc., to overcome the large side effects and promote the improvement of gastrointestinal motility. Effect

Inactive Publication Date: 2010-09-01
NORTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In severe cases, it can cause adverse reactions such as myoclonic convulsions, extrapyramidal reactions, liver damage, and allergic purpura; cisapride can cause cardiac QT interval prolongation or torsades de pointes in hypersensitive patients ; Erythromycin also causes cardiac QT prolongation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Rough extraction of the active part: wash the aboveground part of the mustard, dry it in the shade, crush it, weigh 50g, extract with 8 times the amount of distilled water under hot reflux for 3 times, each time for 1h, combine the extracts, concentrate under reduced pressure and dilute to 50mL. An extract of the mustard with a concentration of 2.0 g crude drug / mL was obtained.

[0016] Then, 2.0 g crude drug / ml, 1.0 g crude drug / ml and 0.5 g crude drug / ml dilutions of the extract of the mustard were prepared respectively, as the large, medium and small dose groups of the extract of the mustard water.

[0017] Method for measuring gastrointestinal motility activity:

[0018] 48 Kunming mice were randomly divided into 4 groups with 12 mice in each group. Among them, the model control group: 20ml / kg distilled water; the large, medium and small dose groups of the water extract of mustard: 40g / kg, 20g / kg, 10g / kg. Continuous gavage for 7 days. Fasting for 24h (free drinki...

Embodiment 2

[0020] Rough extraction of the active part: wash the aboveground part of the mustard, dry it naturally, crush it, weigh 50g, extract 3 times with 8 times the amount of 95% ethanol under reflux, each time for 1h, combine the extracts, concentrate under reduced pressure and dilute to volume 50mL. An extract of the mustard with a concentration of 2.0 g crude drug / mL was obtained.

[0021] Then, 2.0 g crude drug / ml, 1.0 g crude drug / ml and 0.5 g crude drug / ml dilutions of the extract of the mustard were prepared respectively, as the large, medium and small dose groups of the extract of the mustard water.

[0022] Assay method for promoting gastrointestinal motility activity: the assay method is the same as that described in Example 1. The results showed that when the dosage was 10-20g crude drug / kg, the number of stools increased significantly, and the number of stools increased by up to 146.88%.

Embodiment 3

[0024] Rough extraction of active parts: the preparation method of the extract is the same as that described in Example 1.

[0025] Method for measuring gastrointestinal motility activity:

[0026] 48 mice, half male and half male, were randomly divided into 4 groups, 12 mice in each group. Grouping and dosage are the same as in Example 1. Oral administration once a day for 7 consecutive days. Fasting for 24 hours (free drinking water) before the last administration, 90 minutes after administration, each mouse was given 0.2 mL of 20 g / L blue dextran-2000 solution by intragastric administration. After 20 minutes, the mice were sacrificed by cervical dislocation, the stomach was taken, ligated at the cardia and pylorus, the stomach was cut open along the greater curvature of the stomach, and the pigment residue in the stomach was fully washed in 4 mL of deionized water, centrifuged at 3500 r / min for 15 min, and taken The absorbance of the supernatant was measured at 620nm, an...

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PUM

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Abstract

The invention discloses a cornutcd pugionium extractive and an application thereof in promoting a gastrointestinal motion function. The technical scheme is as follows: washing, drying and pulverizing an overground part of fresh cornutcd pugionium; extracting with 5-10 times of water or 95% of ethanol hot reflux for 1-3 times for 0.5-2 hours every time; filtering and then merging filter liquor; and then concentrating into the density of 1-2g of a crude drug / mL. A medicine for enhancing gastrointestinal motion can be developed by the cornutcd pugionium extractive, which can overcome the defect of a chemical synthesis drug of big side effects, and gently and constantly promoting improvement of gastrointestinal motion.

Description

technical field [0001] The present invention relates to the extract of the mustard and its application in promoting the motility function of the gastrointestinal tract. Background technique [0002] Gastrointestinal motility disorders, such as gastroesophageal reflux disease (GERD), functional dyspepsia (FD), gastroparesis (GP), intestinal pseudo-obstruction (IPD), irritable bowel syndrome (IBS) ) and chronic constipation (chronic constipation) are clinically multiple symptoms, and the incidence rate is very high worldwide. Although these diseases have functional or organic causes, the application of prokinetic drugs to restore or enhance the weakened gastrointestinal motility is the main measure of the treatment of these diseases. Therefore, the study of drugs that promote gastrointestinal motility has always been one of the key topics in medical research. [0003] The drugs that have been formally put into clinical use are mostly chemical synthetic drugs, which can be di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/31A61P1/14
Inventor 申烨华惠琅李聪张弛张应龙
Owner NORTHWEST UNIV
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