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Antimicrobial gas-releasing ear drainage tubes

An anti-microbial and gas technology, applied in the direction of wound drainage devices, antibacterial drugs, drug combinations, etc., can solve the problems that the embedded structure is not suitable, the effectiveness is not good, and the possibility is small

Inactive Publication Date: 2010-09-15
ENOX BIOPHARMA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the Mayfow patent found such embedded structures to be less desirable because the antimicrobial metal compound embedded in the conduit sidewall was less likely to encounter migrating microorganisms and was deduced to be less effective than surface coatings

Method used

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  • Antimicrobial gas-releasing ear drainage tubes
  • Antimicrobial gas-releasing ear drainage tubes
  • Antimicrobial gas-releasing ear drainage tubes

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0041] A plurality of vent tubes (1.25 mm Sheehy ring knobs, Cat. No. 23-40300; Inovotec International Inc., Jacksonville, Jacksonville, Florida, USA) were attached to a polytetrafluoroethylene (PTFE) substrate. , FL, USA)) into ventilated Petri dishes. Appropriate conduits were used to connect the Petri dishes to a manifold connected to a gas cylinder containing gNO manufactured by Airgas (Chicago Il, USA). The manifold was provided with an airflow controller adjusted to flow at 30cc min -1 A flow rate of 22,000 ppm gNO was delivered to each Petri dish for 22 hours. After completion of the gNO filling process, store the gNO filled PTFE vent tubes in an airtight container. After completing the gNO filling process, perform all handling of the vent tube using aseptic technique.

[0042] Stock cultures of Streptococcus pyogenes (ATCC #51878), Streptococcus pneumoniae (ATCC #10015), Moraxella catarrhalis (ATCC #25240) and Haemophilus influenzae (ATCC #35540) were maintained on ...

example 2

[0045]A plurality of vent tubes comprising a PTFE substrate (Armstrong Beveled venttube, circular 1.14 mm diameter fluoroplastic, from Gyrus ACMI, Cat. No. 140242; Florida, USA Innovite International, Jacksonville) in vented petri dishes. A suitable conduit was used to connect the petri dish to a manifold connected to a gas cylinder containing gNO manufactured by Elgers (Chicago, IL, USA). The manifold was provided with an airflow controller adjusted to flow at 30cc min -1 A flow rate of 22,000 ppm gNO was delivered to each Petri dish for 22 hours. After completion of the gNO filling process, store the gNO filled PTFE vent tubes in an airtight container. After completing the gNO filling process, perform all handling of the vent tube using aseptic technique.

[0046] A stock culture of methicillin-resistant Staphylococcus aureus (MRSA; ATCC #700698) was maintained on nutrient agar. MSRA is a strain of S. aureus known to be resistant to a variety of broad-spectrum antibiotic...

example 3

[0049] The first batch of vent tubes comprising a silicon substrate (T-Tubes, Silicone Myringotomy Tubing, 23-50600; Innovite International, Jacksonville, FL, USA) and the second batch of vent tubes comprising PTFE Ventilation tubes for the substrate (Hey ring knob, fluoroplastic myringotomy tubing, 23-40300; Innovit International, Jacksonville, FL, USA) were placed in vented petri dishes. A suitable conduit was used to connect the petri dish to a manifold connected to a gas cylinder containing gNO manufactured by Elgers (Chicago, IL, USA). The manifold was provided with an airflow controller adjusted to flow at 30cc min -1 A flow rate of 22,000 ppm gNO was delivered to each Petri dish for 22 hours. After completion of the gNO filling process, the silicon and PTFE vents filled with gNO were stored in airtight containers. After completing the gNO filling process, perform all handling of the vent tube using aseptic technique.

[0050] A stock culture of Staphylococcus aureus ...

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PUM

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Abstract

A nitric oxide gas-releasing conduit configured for surgical implantation through a patient's tympanic membrane. The nitric oxide gas-releasing conduit comprises a gas-permeable cured resin material configured for releasably sequestering therein gas. The gas-permeable cured resin material is charged with nitric oxide gas. The nitric oxide gas-releasing conduit may be optionally coated with an antimicrobial gas-releasing composition. The gas-releasing coating composition may be configured to release nitric oxide.

Description

technical field [0001] The present invention relates to ear drainage tubes. More particularly, the present invention relates to gas releasing antimicrobial ear drainage tubes. Background technique [0002] Insertion of a tympanic tube for the treatment of otitis media with effusion is a commonly performed surgical procedure in patients with recurrent acute otitis media in North America and elsewhere. In this procedure, the eardrum is cut, fluid is aspirated from the middle ear and a tympanostomy tube is inserted. The tube can be of various configurations and materials and is effective in correcting hearing loss caused by effusion simply by placing the tube in the ear. Materials that can be used to manufacture tympanic tubes include thermoplastics, such as modified elastomers and olefins; thermosets, such as silicone and polytetrafluoroethylene; and metals, such as stainless steel and titanium. Children who are unresponsive to antibiotics and have persistent middle ear eff...

Claims

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Application Information

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IPC IPC(8): A61L31/16A61F11/00A61K33/00A61L31/04
CPCA61L2300/404A61K33/00A61L2430/14A61L31/16A61L31/10A61L2300/114A61L31/04A61L2300/45A61F11/002A61P31/00A61P31/06A61F11/202A61M27/002
Inventor 优素福·阿-盖伊戴维·格林伯格
Owner ENOX BIOPHARMA INC
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