Glycerol/fructose composite and preparation method thereof
A technology of composition and fructose, which is applied in the direction of drug combination, active ingredients of hydroxyl compounds, medical preparations containing active ingredients, etc., to achieve the effect of reducing intracranial pressure, lasting for a long time, and reducing the burden on the kidneys
Active Publication Date: 2011-09-07
西安万隆制药股份有限公司
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However, how to improve the components and preparation methods of the glycerin and fructose composition in practice so as to improve the clinical treatment effect of patients with brain and cranial diseases is still a problem that needs to be improved
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[0012] The present invention relates to a kind of glycerin and fructose composition, it is characterized in that, according to the dosage of 1000 bottles of the preparation, its parts by weight are as follows:
[0013] Glycerin 25kg
[0014] Fructose 12.5kg
[0016] Add water for injection to 250,000ml
[0017] A preparation method of a glycerol and fructose composition, characterized in that the method comprises the steps of:
[0018] (1) Take glycerin, fructose, sodium chloride of prescription quantity, be placed in suitable aseptic container;
[0019] (2) Add water for injection, stir to make it dissolve;
[0020] (3) Add activated carbon (0.08%) for needles, stir, keep slightly boiling (100°C) for 15 minutes, decarbonize and filter with a titanium filter stick while it is hot;
[0021] (4) Add water for injection to the full amount, adjust the pH value to 3.0-6.0 with 0.1mol / L hydrochloric acid solution, filter with two microporous memb...
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The present invention relates to a preparing method for glycerol / fructose composite. The preparing method comprises the following steps: (1) the composite in preparation consumption by 1,000 bottles comprises the following components by weight part: 25kg of glycerol, 12.5kg of fructose, 2.25kg of sodium chloride and water for injection added to 250,000ml, then stirring to dissolve the components; (2) adding 0.08% active carbon for needles, stirring, keep boiling gently for 15min, and immediately decarburizing and filtering with a titanium filter rod; (3) further adding the water for injection to the required amount, adjusting the pH value to 3.0 to 6.0 by the 0.1mol / L hydrochloric acid solution, filtering with a phi 0.22mu microporous membrane and a phi 0.45mum microporous membrane, and determining (the content and pH value of) the intermediates; (4) filling and capping after the intermediates are determined to be qualified; and (5) sterilizing at high temperature. The product of the present invention achieves the effect of effectively reducing the intracranial pressure, has long duration and avoids the rebound; meanwhile, the urine volume thereof is obviously lower than the same of patients to whom mannitol is administered, thus reducing the load of the kidney; and the product can further provide the patients with certain energy.
Description
technical field [0001] The invention relates to a pharmaceutical composition injection belonging to the technical field of medicine preparation, in particular to a glycerin and fructose composition and a preparation method thereof. Background technique [0002] In the prior art, glycerin and fructose injections are mainly used for acute and chronic increased intracranial pressure and cerebral edema caused by cerebrovascular disease, traumatic brain injury, brain tumor, intracranial inflammation and other causes. High intracranial pressure is the most common disease in neurosurgery. Mannitol has been used in clinical treatment for a long time, and the effect is good, but it has many side effects such as rebound phenomenon, electrolyte disorder, and renal function damage. Since 1961, Virno in the United States used glycerol Antihypertensive, because of its hemolytic side effects, it has not been widely promoted. Since the 1980s, the research on the compatibility of glycerol h...
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IPC IPC(8): A61K31/7004A61K31/047A61K47/02A61P9/12A61P7/10
Inventor 郑方晔刘护鱼周小园於长权
Owner 西安万隆制药股份有限公司