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Medicinal composition for treating hypertension

A composition and drug technology, applied in the field of medicine, to achieve the effects of reducing insulin resistance, reducing drug side effects, and increasing treatment costs

Active Publication Date: 2010-10-06
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Chinese patent CN1883478 discloses a pharmaceutical composition for treating hypertensive cardiovascular disease, comprising levamlodipine and losartan, irbesartan, valsartan, eprosartan, candesartan or tasosartan Tan, and discloses that the pharmaceutical composition can be made into tablets, granules, capsules, injections, and sustained-release formulations, but its preparation examples only disclose irbesartan, valsartan and levamlor Dipine ratio, the pharmacodynamics example only discloses the pharmacodynamic effects of irbesartan and levamlodipine

Method used

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  • Medicinal composition for treating hypertension
  • Medicinal composition for treating hypertension
  • Medicinal composition for treating hypertension

Examples

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Effect test

Embodiment 1

[0018] The preparation of embodiment 1 compound tablet

[0019] Levoamlodipine Besylate 5g

[0020] Losartan Potassium 45g

[0021] Starch 60g

[0022] Microcrystalline Cellulose 110g

[0023] L-HPC 30g

[0024] 10% starch slurry appropriate amount

[0025] Magnesium Stearate 2g

[0026] Preparation Process:

[0027] Pass the levamlodipine besylate, losartan potassium, starch, microcrystalline cellulose and L-HPC in the prescription through a 100-mesh sieve, mix well, add 10% starch slurry to granulate, and dry below 50°C , 18-mesh sieve, add the prescribed amount of magnesium stearate, mix well, and tablet it.

Embodiment 2

[0028] The preparation of embodiment 2 compound tablet

[0029] Levoamlodipine Maleate 5g

[0030] Losartan 1g

[0031] Lactose 20g

[0032] Microcrystalline Cellulose 60g

[0033] Cross-linked polyvinylpyrrolidone 5g

[0034] 10% starch slurry appropriate amount

[0035] Magnesium Stearate 1g

[0036] Preparation Process:

[0037] Pass the levamlodipine maleate, losartan, lactose, microcrystalline cellulose and cross-linked polyvinylpyrrolidone in the prescription through a 100-mesh sieve, mix well, add 10% starch slurry to granulate in an appropriate amount, and bake at a temperature below 60°C. Dry, granulate with 18-mesh sieve, add prescription amount of magnesium stearate, mix evenly, and compress into tablets.

Embodiment 3

[0038] The preparation of embodiment 3 compound tablet

[0039] Levoamlodipine Besylate 5g

[0040] Losartan Potassium 25g

[0041] Microcrystalline Cellulose 180g

[0042] Starch 15g

[0043] Sodium carboxymethyl starch 20g

[0044] Magnesium Stearate 1.5g

[0045] 5% PVP in absolute ethanol solution

[0046] Preparation process: first put levamlodipine besylate and starch into a mortar, grind and mix evenly, then add sodium carboxymethyl starch and microcrystalline cellulose and mix evenly, finally add losartan potassium and mix evenly, use 5% The anhydrous ethanol solution of PVP is used as a binder to granulate, dried at 40°C, granulated, mixed with magnesium stearate, and compressed into tablets.

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Abstract

The invention relates to a medicinal composition for treating hypertension, in particular to a medicinal composition containing low-dose Losartan, and belongs to the field of medicaments. The medicinal composition of hypertension resistance contains the following effective doses of medicaments: Levamlodipine or medicinal salts thereof and the Losartan, wherein the Levamlodipine is based on free alkali, the Losartan is based on free acid, and the weight ratio of the Levamlodipine to the Losartan is 1:0.2-9. The medicinal composition provided by the invention enhances the treatment effect, and reduces the treatment risks of patients.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a pharmaceutical composition for treating hypertension, in particular to a pharmaceutical composition containing low-dose losartan. Background technique [0002] Hypertension is the most common cardiovascular disease and has become a major public health problem worldwide. According to statistics from the national health department, by the end of 2006, the number of hypertensive patients in my country had reached 160 million, and more than 3 million new patients were added every year. [0003] Hypertension is a syndrome with very complicated etiology and pathogenesis. Once diagnosed, it requires life-long medication. At present, domestic and foreign medical circles generally tend to use two antihypertensive drugs with different mechanisms of action in combination. According to the sixth report of the National Committee on the Prevention, Detection, Evaluation, and Treatment of Hypertension,...

Claims

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Application Information

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IPC IPC(8): A61K31/4422A61K31/4178A61P9/12
Inventor 赵志全
Owner LUNAN PHARMA GROUP CORPORATION
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