Medicinal composition for treating hypertension

A composition and drug technology, applied in the field of medicine, to achieve the effects of reducing insulin resistance, reducing drug side effects, and increasing treatment costs

Active Publication Date: 2010-10-06
LUNAN PHARMA GROUP CORPORATION
View PDF3 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Chinese patent CN1883478 discloses a pharmaceutical composition for treating hypertensive cardiovascular disease, comprising levamlodipine and losartan, irbesartan, valsartan, eprosartan, candesartan or tasosartan Tan, and discloses that the pharmaceutical composition can be

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medicinal composition for treating hypertension
  • Medicinal composition for treating hypertension
  • Medicinal composition for treating hypertension

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0018] Example 1 Preparation of compound tablets

[0019] L-Amlodipine Besylate 5g

[0020] Losartan Potassium 45g

[0021] Starch 60g

[0022] Microcrystalline cellulose 110g

[0023] L-HPC 30g

[0024] 10% starch slurry appropriate amount

[0025] Magnesium stearate 2g

[0026] Preparation Process:

[0027] Pass the L-Amlodipine Besylate, Losartan Potassium, Starch, Microcrystalline Cellulose and L-HPC in the prescription through a 100-mesh sieve respectively, mix well, add 10% starch slurry to granulate, and dry below 50℃ , 18-mesh sieve into the granules, add the prescribed amount of magnesium stearate and mix well, then press the tablet to obtain.

Example Embodiment

[0028] Example 2 Preparation of compound tablets

[0029] L-Amlodipine Maleate 5g

[0030] Losartan 1g

[0031] 20g lactose

[0032] Microcrystalline cellulose 60g

[0033] Cross-linked polyvinylpyrrolidone 5g

[0034] 10% starch slurry appropriate amount

[0035] Magnesium stearate 1g

[0036] Preparation Process:

[0037] Pass the levoamlodipine maleate, losartan, lactose, microcrystalline cellulose and cross-linked polyvinylpyrrolidone in the prescription respectively through a 100-mesh sieve, mix well, add an appropriate amount of 10% starch slurry to granulate, and bake below 60℃ Dried, 18-mesh sieve into the granules, add the prescribed amount of magnesium stearate and mix well, then press the tablet to obtain.

Example Embodiment

[0038] Example 3 Preparation of compound tablets

[0039] L-Amlodipine Besylate 5g

[0040] Losartan potassium 25g

[0041] Microcrystalline cellulose 180g

[0042] Starch 15g

[0043] Sodium Carboxymethyl Starch 20g

[0044] Magnesium stearate 1.5g

[0045] 5% PVP in absolute ethanol solution

[0046] Preparation process: first put the levamlodipine besylate and starch into a mortar, grind and mix uniformly, add sodium carboxymethyl starch, microcrystalline cellulose and mix uniformly, and finally add Losartan potassium and mix well, with 5% PVP's anhydrous ethanol solution is used as a binder for granulation, dried at 40°C, granulated, mixed with magnesium stearate, and compressed to obtain a tablet.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a medicinal composition for treating hypertension, in particular to a medicinal composition containing low-dose Losartan, and belongs to the field of medicaments. The medicinal composition of hypertension resistance contains the following effective doses of medicaments: Levamlodipine or medicinal salts thereof and the Losartan, wherein the Levamlodipine is based on free alkali, the Losartan is based on free acid, and the weight ratio of the Levamlodipine to the Losartan is 1:0.2-9. The medicinal composition provided by the invention enhances the treatment effect, and reduces the treatment risks of patients.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a pharmaceutical composition for treating hypertension, in particular to a pharmaceutical composition containing low-dose losartan. Background technique [0002] Hypertension is the most common cardiovascular disease and has become a major public health problem worldwide. According to statistics from the national health department, by the end of 2006, the number of hypertensive patients in my country had reached 160 million, and more than 3 million new patients were added every year. [0003] Hypertension is a syndrome with very complicated etiology and pathogenesis. Once diagnosed, it requires life-long medication. At present, domestic and foreign medical circles generally tend to use two antihypertensive drugs with different mechanisms of action in combination. According to the sixth report of the National Committee on the Prevention, Detection, Evaluation, and Treatment of Hypertension,...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/4422A61K31/4178A61P9/12
Inventor 赵志全
Owner LUNAN PHARMA GROUP CORPORATION
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap