35results about How to "Improved benefit/cost ratio" patented technology

The invention belongs to the field of medicine technology, provides a medicinal composition containing zafirlukast and statins, and also provides application of the medicinal composition in preparation of medicines for treating asthma disease. The medicinal composition provided by the invention specially contains two medicinal active components of zafirlukast and 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase inhibitor, wherein the mass ratio of zafirlukast to the 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase inhibitor is 1 to (0.01-10). In addition, a compound preparation provided by the invention can be prepared into an orally administered preparation or a parentarally administered preparation.

The invention belongs to the filed of medicine and discloses a pharmaceutical composition using fimasartan and rosuvastatin or medicinal salt thereof as active components, wherein a mass ratio of rosuvastatin or medicinal salt thereof to fimasartan is 1:0.25-250 and preferably 1:10-100. The pharmaceutical composition containing rosuvastatin medicinal salt thereof and fimasartan has obvious synergism on treating hypertension and complications thereof, low treatment cost, little side-effect and good clinic application prospect.

The invention discloses a pharmaceutical composition for treating chronic cardiac failure and application thereof. The pharmaceutical composition contains the following two active ingredients: (1), N-methyltyramine or a medicinal salt thereof; (2), any one angiotensin converting enzyme inhibitor. The pharmaceutical composition disclosed by the invention can be used for cooperatively increasing left ventricular systolic pressure, lowering left ventricular end diastolic pressure and improving the sexual function of a rat with chronic cardiac failure, so that the cardiac hypertrophy symptom of a heart failure patient can be reversed, and the effect for treating chronic cardiac failure can be brought into play.

The invention discloses a medicine composition with active components of carvedilol and a medicinal salt thereof, and fimasartan. The invention also relates to an application of the medicine composition in treating hypertension and complications thereof, and an application of the medicine composition in treating congestive cardiac failure. In the medicine composition, a weight ratio of carvedilol and medicinal salt thereof to fimasartan is 1:0.01-1000. The components of the medicine composition are clear. When the medicine composition is used for treating hypertension and complications thereof, a substantial synergetic effect of the two medicine components is shown, and stable reduction of blood pressure can be realized; when the medicine composition is used for treating congestive cardiac failure, various cardiac indexes are substantially enhanced, a treatment effect is substantial, and a substantial synergetic effect of the two medicine components is shown.

The invention discloses a medicinal composition for treating hypertension, and belongs to the field of medicaments. The antihypertensive medicinal composition comprises a pharmaceutically effective dose of levoamlodipine or a pharmaceutically acceptable salt thereof and losartanpotassium, wherein the levoamlodipine is weighed in free alkali; the losartan is weighed in free acid; and the weight ratio of the levoamlodipine to the losartan is 1 to 11-19. The medicinal composition does not damage the target organ while reducing the blood pressure so as to enhance the therapeutic effect and reducethe risk for therapy of a patient.

The invention relates to a traditional Chinese medicine composition for treating male erectile dysfunction and an application thereof, belonging to the field of medicines. In order to overcome the defects that the existing medicine for treating male erectile dysfunction has the disadvantages of adverse reaction, short action time or slow effectiveness, the invention provides a traditional Chinese medicine composition capable of treating the male erectile dysfunction. The traditional Chinese medicine composition is mainly prepared from the following raw materials in parts by weight: 8-20 parts of cassia twig, 5-15 parts of glossy privet fruit, 5-15 parts of Rehmannia Glutinosa, 3-10 parts of herba epimedii, 10-25 parts of Chinese yam, 5-15 parts of morinda officinalis, 10-20 parts of Mangnolia officinalis, 3-10 parts of fresh ginger, 10-20 parts of prepared tuber of multiflower knotweed, 8-20 parts of astragalus, 5-12 parts of lily, 10-20 parts of poria cocos, 3-10 parts of cistanche, 5-15 parts of angelica sinensis, 3-10 parts of codonopsis pilosula, 3-10 parts of wolfberry, 5-12 parts of spina date seeds, 10-15 parts of scutellaria baicalensis, 10-20 parts of honeysuckle, 3-10 parts of fructus forsythiae, 5-15 parts of bighead atractylodes rhizome, 5-15 parts of the root of Chinese pulsatilla, 5-25 parts of Chinese gall and 10-20 parts of liquorice. The traditional Chinese medicine composition can obviously shorten the erection latency and obviously prolong the ejaculatory latency time and has an excellent effect of treating nervous ED.

The invention discloses a compound preparation of quetiapine fumarate and lurasidone, which is used for treating schizophrenia. Each preparation unit contains the quetiapine fumarate with the effective dosage of 25-300mg and the lurasidone with the effective dosage of 20-100mg. The dosage of the compound preparation is obviously lower than those of other medicines which are singly used, and the compound preparation has the function of synergy, so that the compound preparation is suitable for severe schizophrenia patients.

The invention belongs to the field of medicine, and relates to a pharmaceutical composition and its application in preparing medicine for treating cerebral edema. Cerebral edema is common in neurological diseases, and there is no ideal treatment drug in clinical practice. Moreover, there are technical problems of inaccurate therapeutic effect and large adverse drug reactions in the prior art. In order to solve this situation, the object of the present invention is to provide a pharmaceutical composition for preventing and treating cerebral edema, which can be used in traumatic brain injury, cerebral hemorrhage, When used after cerebral infarction, meningitis, brain tumor and other injuries and brain surgery, it has a good therapeutic effect on cerebral edema, and compared with the prior art, it has the advantages of less dosage, quick effect and obvious effect.

The invention discloses a pharmaceutical composition containing cyanidenon and use thereof. The active component of the pharmaceutical composition is prepared from olmesartan medoxomil and cyanidenon, and the weight ratio of the olmesartan medoxomil to the cyanidenon is preferably 1:(2-20). The blood pressure can be slowly and stably reduced by adopting low-dosage cyanidenon combined with olmesartan medoxomil, so that protection of structure and function of the hypertensive target organ is facilitated, and the occurrence rate of a cardiovascular event is further reduced.

The invention provides a novel pharmaceutical composition for treating hypertension, and relates particularly to a pharmaceutical composition comprising S-metoprolol and angiotensin II receptor antagonist, wherein the angiotensin II receptor antagonist includes losartan, valsartan, telmisartan, irbesartan or olmesartan; and the weight ratio of S-metoprolol to angiotensin II receptor antagonist is1:(0.1-5), preferably 1:(0.25-2), more preferably 1:(0.5-1.1). The inventive composition is very important for long-term survival rate of hypertensive patients, and has a positive impact on the prognosis of hypertension for patients.

A pharmaceutical composition for treating hypertension belongs to the field of medicine, in particular to a pharmaceutical composition containing low-dose losartan. The antihypertensive pharmaceutical composition of the present invention contains a pharmaceutically effective amount of levamlodipine or a pharmaceutically acceptable salt thereof and losartan, wherein, levamlodipine is calculated as free base, losartan is calculated as free acid, and levartan is calculated as free acid. The weight ratio of clodipine to losartan is 1:0.2-9. The pharmaceutical composition provided by the present invention enhances the treatment effect and reduces the treatment risk of the patient.

The invention discloses a pharmaceutical composition for treating or preventing diabetes or its complications and an application thereof, and belongs to the medical field. According to the pharmaceutical composition, an insulin sensitizer and bromocriptine or its medicinal salt are used as active pharmaceutical ingredients. When the pharmaceutical composition is used to treat or prevent diabetes or its complications, the medical action modes are complementary. Therefore, the pharmaceutical composition shows remarkable synergism in the hypoglycemic aspect, has low adverse reaction, requires a low price and has a good application prospect.