Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of pharmaceutical composition for treating hypertension

A composition and a technique for hypertension are applied in the field of medicine to achieve the effects of reducing the incidence rate, enhancing the treatment effect and increasing the treatment compliance

Active Publication Date: 2012-02-01
LUNAN PHARMA GROUP CORPORATION
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Chinese patent CN1883478 discloses a pharmaceutical composition for treating hypertensive cardiovascular disease, comprising levamlodipine and losartan, irbesartan, valsartan, eprosartan, candesartan or tasosartan Tan, and discloses that the pharmaceutical composition can be made into tablets, granules, capsules, injections, and sustained-release formulations, but its preparation examples only disclose irbesartan, valsartan and levamlor Dipine ratio, the pharmacodynamics example only discloses the pharmacodynamic effects of irbesartan and levamlodipine

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of pharmaceutical composition for treating hypertension
  • A kind of pharmaceutical composition for treating hypertension
  • A kind of pharmaceutical composition for treating hypertension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The preparation of embodiment 1 compound tablet

[0019] Levoamlodipine Besylate 5g

[0020] Losartan Potassium 45g

[0021] Starch 60g

[0022] Microcrystalline Cellulose 110g

[0023] L-HPC 30g

[0024] 10% starch slurry appropriate amount

[0025] Magnesium Stearate 2g

[0026] Preparation Process:

[0027] Pass the levamlodipine besylate, losartan potassium, starch, microcrystalline cellulose and L-HPC in the prescription through a 100-mesh sieve, mix well, add 10% starch slurry to granulate, and dry below 50°C , 18-mesh sieve, add the prescribed amount of magnesium stearate, mix well, and tablet it.

Embodiment 2

[0028] The preparation of embodiment 2 compound tablet

[0029] Levoamlodipine Maleate 5g

[0030] Losartan 1g

[0031] Lactose 20g

[0032] Microcrystalline Cellulose 60g

[0033] Cross-linked polyvinylpyrrolidone 5g

[0034] 10% starch slurry appropriate amount

[0035] Magnesium Stearate 1g

[0036] Preparation Process:

[0037] Pass the levamlodipine maleate, losartan, lactose, microcrystalline cellulose and cross-linked polyvinylpyrrolidone in the prescription through a 100-mesh sieve, mix well, add 10% starch slurry to granulate in an appropriate amount, and bake at 60 ° C Dry, granulate with 18-mesh sieve, add prescription amount of magnesium stearate, mix evenly, and compress into tablets.

Embodiment 3

[0038] The preparation of embodiment 3 compound tablet

[0039] Levoamlodipine Besylate 5g

[0040] Losartan Potassium 25g

[0041] Microcrystalline Cellulose 180g

[0042] Starch 15g

[0043] Sodium carboxymethyl starch 20g

[0044] Magnesium Stearate 1.5g

[0045] 5% PVP in absolute ethanol solution

[0046] Preparation process: first put levamlodipine besylate and starch into a mortar, grind and mix evenly, then add carboxymethyl starch sodium, microcrystalline cellulose and mix evenly, finally add losartan potassium and mix evenly, use 5% The anhydrous ethanol solution of PVP is used as a binder to granulate, dried at 40°C, granulated, mixed with magnesium stearate, and compressed into tablets.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A pharmaceutical composition for treating hypertension belongs to the field of medicine, in particular to a pharmaceutical composition containing low-dose losartan. The antihypertensive pharmaceutical composition of the present invention contains a pharmaceutically effective amount of levamlodipine or a pharmaceutically acceptable salt thereof and losartan, wherein, levamlodipine is calculated as free base, losartan is calculated as free acid, and levartan is calculated as free acid. The weight ratio of clodipine to losartan is 1:0.2-9. The pharmaceutical composition provided by the present invention enhances the treatment effect and reduces the treatment risk of the patient.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a pharmaceutical composition for treating hypertension, in particular to a pharmaceutical composition containing low-dose losartan. Background technique [0002] Hypertension is the most common cardiovascular disease and has become a major public health problem worldwide. According to statistics from the national health department, by the end of 2006, the number of hypertensive patients in my country had reached 160 million, and more than 3 million new patients were added every year. [0003] Hypertension is a syndrome with very complicated etiology and pathogenesis. Once diagnosed, it requires life-long medication. At present, domestic and foreign medical circles generally tend to use two antihypertensive drugs with different mechanisms of action in combination. According to the sixth report of the National Committee on the Prevention, Detection, Evaluation, and Treatment of Hypertension,...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4178A61P9/12A61K31/4422
Inventor 赵志全
Owner LUNAN PHARMA GROUP CORPORATION
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com