Medicine composition containing zafirlukast and statin medicine

A technology of composition and medicine, which is applied in the field of medicine, can solve problems that have not been reported, and achieve good therapeutic effects, lower incidence rates, and increased treatment compliance

Inactive Publication Date: 2012-03-28
刘树芹
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In addition, zafirlukast and statins are used as a compound to treat respiratory diseases, which has not been reported in the prior art

Method used

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  • Medicine composition containing zafirlukast and statin medicine
  • Medicine composition containing zafirlukast and statin medicine
  • Medicine composition containing zafirlukast and statin medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1 Preparation of tablets

[0031]

[0032] Preparation process: pravastatin, zalukast, microcrystalline cellulose and sodium carboxymethyl starch are mixed uniformly, an appropriate amount of starch slurry is added to make soft material, and then it is granulated through a 16-mesh sieve. The wet granules are dried at 60°C, the dry granules are sieved through a 16-mesh sieve, and the fine powder in the dry granules is sieved, mixed with magnesium stearate, and then mixed with the dry granules, and then compressed into tablets.

Embodiment 2

[0033] Example 2 Preparation of tablets

[0034]

[0035]

[0036] Preparation process: rosuvastatin, zalukast, microcrystalline cellulose and sodium carboxymethyl starch are mixed uniformly, an appropriate amount of starch slurry is added to make soft material, and then it is granulated through a 16-mesh sieve. The wet granules are dried at 60°C, the dry granules are sieved through a 16-mesh sieve, and the fine powder in the dry granules is sieved, mixed with magnesium stearate, and then mixed with the dry granules, and then compressed into tablets.

Embodiment 3

[0037] Example 3 Preparation of tablets

[0038]

[0039] Preparation process: rosuvastatin, zalukast, microcrystalline cellulose and sodium carboxymethyl starch are mixed uniformly, an appropriate amount of starch slurry is added to make soft material, and then it is granulated through a 16-mesh sieve. The wet granules are dried at 60°C, the dry granules are sieved through a 16-mesh sieve, and the fine powder in the dry granules is sieved, mixed with magnesium stearate, and then mixed with the dry granules, and then compressed into tablets.

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PUM

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Abstract

The invention provides a medicine composition containing zafirlukast and statin medicine and discloses an application of the medicine composition to the preparation of medicine for treating asthma, which belong to the technical field of medicine. Concretely, the medicine composition contains two medicine active ingredients: zafirlukast and 3-oxhydryl-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors according to the mass ratio of 1;(0.01 to 10). In addition, the compound preparation can be made into oral preparations or intestinal tract external preparations.

Description

Technical field [0001] The present invention belongs to the technical field of medicine, and specifically relates to a pharmaceutical composition of zalukast and statins. Background technique [0002] Bronchial asthma (abbreviated as asthma) is a kind of chronic airway inflammation, which is a chronic inflammation of the airway involving a variety of inflammatory cells. It is characterized by reversible airway obstruction and increased airway reactivity. Airway obstruction is caused by increased secretions caused by bronchial mucosal inflammation, mucosal edema, and inflammation-stimulated smooth muscle spasm; and increased airway reactivity is also due to airway inflammation The result of bronchial epithelial cell damage. People have realized that only by controlling the inflammation of the airway mucosa can the ultimate goal of reducing airway hyperresponsiveness and alleviating asthma symptoms can be achieved. Most of the current researches focus on the airway, and it is beli...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/404A61K31/366A61K31/22A61K31/405A61K31/40A61K31/505A61K31/47A61K31/4709A61P11/06
Inventor 刘树芹
Owner 刘树芹
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