Pharmaceutical composition for treating bronchial asthma

A technology for bronchial asthma and a composition, applied in the field of medicine, can solve problems such as unreported, and achieve the effects of good treatment effect, improvement of quality of life, and reduction of drug side effects

Inactive Publication Date: 2013-05-01
南通纺都资产管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In addition, pranlukast and statins are used as a compound to treat respiratory diseases, which has not been reported in the prior art

Method used

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  • Pharmaceutical composition for treating bronchial asthma
  • Pharmaceutical composition for treating bronchial asthma
  • Pharmaceutical composition for treating bronchial asthma

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Example 1 Preparation of tablets

[0031]

[0032] Preparation process: pravastatin, pranlukast, microcrystalline cellulose and sodium carboxymethyl starch are mixed uniformly, an appropriate amount of starch slurry is added to make soft material, and then it is granulated through a 16-mesh sieve. The wet granules are dried at 60°C, the dry granules are sieved through a 16-mesh sieve, and the fine powder in the dry granules is sifted out, mixed with magnesium stearate, and then mixed with the dry granules, and compressed into tablets.

Embodiment 2

[0033] Example 2 Preparation of tablets

[0034]

[0035] Preparation process: rosuvastatin, pranlukast, microcrystalline cellulose and sodium carboxymethyl starch are mixed uniformly, an appropriate amount of starch slurry is added to make soft material, and then it is granulated through a 16-mesh sieve. The wet granules are dried at 60°C, the dry granules are sieved through a 16-mesh sieve, and the fine powder in the dry granules is sifted out, mixed with magnesium stearate, and then mixed with the dry granules, and compressed into tablets.

Embodiment 3

[0036] Example 3 Preparation of tablets

[0037]

[0038] Preparation process: rosuvastatin, pranlukast, microcrystalline cellulose and sodium carboxymethyl starch are mixed uniformly, an appropriate amount of starch slurry is added to make soft material, and then it is granulated through a 16-mesh sieve. The wet granules are dried at 60°C, the dry granules are sieved through a 16-mesh sieve, and the fine powder in the dry granules is sifted out, mixed with magnesium stearate, and then mixed with the dry granules, and compressed into tablets.

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PUM

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Abstract

The invention belongs to the medical technical field, and relates to a pharmaceutical composition for treating bronchial asthma, in particular to a pharmaceutical composition of Pranlukast and Statins. The pharmaceutical composition contains two active pharmaceutical ingredients such as Zafirlukast and a 3-hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor wherein the ratio of Zafirlukast to 3-hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor is 1:(0.0001-0.01). In addition, the compound preparation in the invention can be made into an oral administration preparation or parenteral administration preparation.

Description

Technical field [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical composition for treating bronchial asthma, in particular to a pharmaceutical composition of Pranlukast and statins. Background technique [0002] Bronchial asthma (abbreviated as asthma) is a kind of chronic airway inflammation, which is a chronic inflammation of the airway involving a variety of inflammatory cells. It is characterized by reversible airway obstruction and increased airway responsiveness. Airway obstruction is caused by increased secretions caused by bronchial mucosal inflammation, mucosal edema and inflammation-stimulated smooth muscle spasm; and increased airway responsiveness is also due to airway inflammation The result of bronchial epithelial cell damage. People have realized that only by controlling the inflammation of the airway mucosa can the ultimate goal of reducing airway hyperresponsiveness and alleviating asthma symptoms can be achieved. M...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/00A61K31/41A61P11/06
Inventor 刘树芹杨恒哲杨西东
Owner 南通纺都资产管理有限公司
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