Drug composition and application thereof

A composition and drug technology, applied in the field of medicine, can solve problems such as the absence of bumetanide and oxiracetam, lack of consensus, irritation at the injection site, etc., to achieve strong anti-cerebral edema, improve drug efficacy, and reduce dosage Effect

Active Publication Date: 2016-04-06
山东罗欣乐康制药有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 3) Drugs such as hormones are used to damage brain cells, and there is still no unified opinion on the application of large doses of hormones
However, when the dosage of piracetam is high, it can cause local irritation and pain at the injection site
[0012] Among the current drugs for the treatment of cerebral edema, there is no report on the combination of bumetanide and oxiracetam or the preparation of a pharmaceutical composition for the treatment of cerebral edema

Method used

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  • Drug composition and application thereof
  • Drug composition and application thereof
  • Drug composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The preparation of embodiment 1 compound tablet

[0033]

[0034]

[0035] Preparation process: firstly mix bumetanide and lactose evenly, then add sodium carboxymethyl starch and microcrystalline cellulose to mix evenly, add oxiracetam and mix evenly, finally add micropowder silica gel and magnesium stearate, mix evenly, press Slices, ready to serve.

Embodiment 2

[0036] The preparation of embodiment 2 compound tablet

[0037]

[0038] Preparation process: first mix bumetanide and lactose evenly, then add microcrystalline cellulose and mix evenly, finally add oxiracetam and mix evenly, and use 5% PVP k3075% ethanol solution is used as a binder to granulate, dried, granulated, added with sodium carboxymethyl starch and magnesium stearate, mixed evenly, and compressed into tablets to obtain.

Embodiment 3

[0039] The preparation of embodiment 3 compound tablet

[0040]

[0041] Preparation process: first mix bumetanide and lactose evenly, then add microcrystalline cellulose and mix evenly, finally add oxiracetam and mix evenly, and use 5% PVP k30 75% ethanol solution is used as a binder to granulate, dried, granulated, added with sodium carboxymethyl starch and magnesium stearate, mixed evenly, and compressed into tablets to obtain.

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Abstract

The invention belongs to the field of medicine and relates to a drug composition and application thereof to preparation of a drug for treating encephaledema. Encephaledema is commonly seen in a nervous system disease, and no ideal treatment drug is available clinically now. There are technical problems of an inaccurate treatment effect and a large adverse drug reaction in the prior art. In order to improve the current situation, the drug composition aims at preventing and treating encephaledema and has a good curative effect on encephaledema when used for treating brain traumas, cerebral hemorrhage, cerebral infarction, meningitis, brain tumors and other diseases and used after brain surgery. Compared with the prior art, the drug composition has the advantages of being small in dosage, taking effect quickly and being obvious in effect.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a pharmaceutical composition and its application, in particular, to a pharmaceutical composition with bumetanide and oxiracetam as active ingredients, and its use in the preparation of medicines for treating cerebral edema the use of. Background technique [0002] Cerebral edema refers to the pathological phenomenon that the increase of water in the brain leads to the increase of brain volume, and it is the response of brain tissue to various pathogenic factors. It can cause intracranial hypertension and damage brain tissue. Clinically, it is common in neurological diseases, such as craniocerebral trauma, intracranial infection (encephalitis, meningitis, etc.), cerebrovascular disease, intracranial space-occupying disease (such as tumor), Seizures and systemic diseases such as toxic dysentery and severe pneumonia. The pathogenesis of cerebral edema is very complicated, and there are many ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4015A61P7/10
Inventor 刘明霞李晓峰张元超
Owner 山东罗欣乐康制药有限公司
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