Asarin composite freeze-dried powder for injection

A technology of freeze-dried powder injection and asarone, which is applied in the direction of freeze-dried delivery, drug combination, powder delivery, etc., can solve the problems of large proportion of excipients added, many types of excipients, and unsatisfactory reconstitution effect, etc., to achieve guaranteed The effects of stability, improving solubility, and reducing the amount of excipients
CN101856334BActive Publication Date: 2011-06-08SHANDONG LUOXIN PHARMA GRP CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANDONG LUOXIN PHARMA GRP CO LTD
Publication Date
2011-06-08

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Abstract

The invention relates to an asarin injection preparation and in particular relates to an asarin composite aseptic freeze-dried powder preparation for injection. The asarin composite freeze-dried powder for injection comprises 4 to 8 grams of asarin, 40 to 80ml of ethanol of which the volume ratio is between 95 and 100 percent and 24 to 80 grams of mannitol. The raw materials is added with water for injection to a volume of 1,000 to 2,000ml and the obtained product is freeze-dried to prepare 500 to 1,000 bottles of the freeze-dried powder, wherein the asarin is ultrafine particles prepared by an anti-solvent crystallization method. The asarin composite preparation for injection also comprises 0.01 to 10 grams of polysorbate-80, preferably 1 to 8 grams of polysorbate-80. Due to adoption of the ultrafine particles of the asarin, which is prepared by the anti-solvent crystallization method, the asarin composite aseptic freeze-dried powder preparation for injection greatly improves solubility property of the asarin so as to obtain the freeze-dried powder preparation with excellent stability and redissolution property by adding a small quantity of cosolvent or without adding the cosolvent when preparing the asarin preparation.
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Description

Technical field

[0001] The invention relates to an injection preparation of Asarone, in particular to a sterile freeze-dried powder injection preparation of Asarone composition for injection. Background technique

[0002] Asarum (2,4,5-trimethoxy-1-propenylbenzene), mainly exists in the volatile oil of Araceae plant Acorus calamus and other plants. Tests have shown that this product can obviously prevent asthma attacks and is close to waiting. Because of its antitussive effect, it also has certain choleretic and sedative effects. Clinically, it is mainly used for the treatment of bronchial asthma, chronic bronchitis, pneumonia and chronic obstructive pulmonary disease with acute inflammation of the lungs.

[0003] In recent years, due to the increase of air pollution and the development of the chemical industry, the incidence of asthma has gradually increased. In the 1940s, the incidence of asthma in developed countries was about 0.5%. According to reports in the United States, ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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