Preparation method of nosiheptide premix
A technology of nosiheptide and premix, which is applied in the field of preparation of feed antibiotics, can solve problems such as polluting the environment and unfavorable environmental protection, and achieves the effects of small investment in equipment, significant economic benefits, and reduced production costs.
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example 1
[0036] Example 1: The preparation method of powdery nosiheptide premix
[0037]Preparation of nosiheptide fermented liquid: connect the nosiheptide-producing bacterial classification into the seed tank, and through expanded cultivation, connect the fermented tank with an inoculation rate of 6 to 20%, and press the volume ratio of air and fermented liquid to be 1: The amount of 0.6-1 is ventilated, the temperature is controlled at 27-30°C, the stirring speed is 120-140 rpm, and sterile aerobic fermentation is carried out. The fermentation process is based on the sugar, pH value, and bacterial morphology. After culturing for 7-10 days, the fermentation is completed, and each liter of fermentation broth contains 1-3 g of nosiheptide.
[0038] The preparation method of powdery nosiheptide premix:
[0039] a. Pretreatment: Take 1000L of Nosiheptide fermented liquid (the fermentation unit of the fermented liquid is 2g / L) obtained through fermentation above, and add ZC-101 flocculan...
Embodiment 2
[0050] Embodiment 2: basically the same as Embodiment 1, the difference is:
[0051] The difference between the preparation method of powdery nosiheptide premix and embodiment 1 is:
[0052] a. Pretreatment: the added ZC-101 flocculant accounts for 0.05% of the total volume of the fermentation broth;
[0053] B, pressure filtration: the nosiheptide fermented liquid after step a pretreatment is carried out flexible pressing, and the maximum pressing pressure of control is 5.0MPa, obtains the wet filter cake containing nosiheptide after the pressure filtration, i.e. nosiheptide wet filter cake 90kg;
[0054] c, filter cake drying and pulverization: pulverize the Nosiheptide wet filter cake obtained in step b, pass through a 20-mesh sieve, and dry with a fluidized bed after pulverization. During drying, the air inlet temperature is controlled to be 120 to 130° C., and the air outlet temperature is 40~65°C, after drying, 49kg of dried product of Nosiheptide mycelium was obtained;...
Embodiment 3
[0063] Embodiment 3: basically the same as Embodiment 1, the difference is:
[0064] The preparation method of granular nosiheptide premix:
[0065] a. Pretreatment: Add 30kg of filter aid diatomaceous earth to 1000L nosiheptide fermentation liquid;
[0066] B, pressure filtration: the Nosiheptide fermented liquid after step a pretreatment is carried out membrane pressure filtration, and the control pressure filtration pressure is 2.0MPa, obtains the wet filter cake containing Nosiheptide after the pressure filtration, i.e. Nosiheptide wet filter cake 180kg ;
[0067] c. Drying and crushing of the filter cake: The nosiheptide wet filter cake obtained in step b is subjected to spin flash drying, and the temperature of the air inlet is controlled to be 160-180°C during flash drying, and the temperature of the air outlet of the material is 70-80°C to obtain that Sipeptide mycelium dry product 80kg;
[0068] Then the obtained nosiheptide mycelium dry product is pulverized, and ...
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