Suspension composition containing lysozyme and florfenicol and preparation method thereof

Abstract

The invention relates to a suspension composition containing lysozyme and florfenicol, which is a microemulsion solution prepared from the lysozyme, the florfenicol, tween-80, sodium citrate, methylparaben, propylene glycol and water for injection. The composition adopts compatibility of the lysozyme and the florfenicol, not only enlarges the antimicrobial spectrum, but also has high efficiency, low toxicity, less residues and drug resistance prevention; and the prepared suspension not only can solve the problem that the florfenicol is hardly soluble in water, improves the biological utilization of the florfenicol, but also protects the activity of the lysozyme in gastrointestinal fluid, and plays a slow release effect on the lysozyme and the florfenicol to ensure that the medicament maintains long-term effective blood concentration in vivo, is integrated with instant effect, high efficiency and long action, and can be used for treating mycoplasma gallisepticum infections of livestock and poultry.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a suspension composition containing lysozyme and florfenicol and a preparation method thereof. Background technique [0002] Lysozyme is a general term for a class of enzymes that dissolve bacterial cell walls. Its antibacterial effect is to make the cell wall insoluble by destroying the β-1,4 glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine in the cell wall. Mucopolysaccharides are decomposed into soluble glycopeptides, causing the cell wall to rupture and the contents to escape and lyse the bacteria. Lysozyme can also bind to various acidic substances that induce inflammation and inactivate them. Lysozyme is clinically used for the treatment and prevention of infections and inflammations caused by various bacteria and viruses, as well as for the prevention and treatment of chronic respiratory tract and chronic bronchitis, and can also be used for non-spec...

AI Technical Summary

Problems solved by technology

Solutions and injections have their unique features in the treatment of severe bacterial infections, but because Florfenicol is insoluble in water, a large amount of organic solvents must be added to dissolve it during preparation, so the cost of preparation is relatively high. Complicated production, harmful to the body of online production employees, etc., and adverse stress response and irritation to animals treated with drugs

However, although the powder and premix are inconvenient and difficult to dissolve in water during prophylaxis, the treatment effect is poor through mixed feeding.

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