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Suspension composition containing lysozyme and florfenicol and preparation method thereof

A technology of florfenicol and lysozyme, applied in the field of medicine, can solve the problems of inconvenient drug administration, complicated production, physical harm to online production employees, etc.

Inactive Publication Date: 2010-11-03
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Solutions and injections have their unique features in the treatment of severe bacterial infections, but because Florfenicol is insoluble in water, a large amount of organic solvents must be added to dissolve it during preparation, so the cost of preparation is relatively high. Complicated production, harmful to the body of online production employees, etc., and adverse stress response and irritation to animals treated with drugs
However, although the powder and premix are inconvenient and difficult to dissolve in water during prophylaxis, the treatment effect is poor through mixed feeding.

Method used

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  • Suspension composition containing lysozyme and florfenicol and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0028] A suspension composition containing lysozyme and florfenicol and its preparation method:

[0029] (1) Weigh 5 parts of lysozyme, put 10 parts of Florfenicol into an appropriate amount of water for injection, add 6 parts of Tween-80, and stir well;

[0030] (2) Add 1 part of sodium citrate and stir well;

[0031] (3) Add 0.3 part of methylparaben, fully stir evenly;

[0032] (4) Add 10 parts of propylene glycol, fully stir evenly;

[0033] (5) Finally, the volume is adjusted to 100 parts with water for injection, fully stirred until uniform, and homogenized twice under a pressure of 30-100Mpa.

[0034] The rotating speed is 1500 rpm, the time is 45 minutes, and the temperature is room temperature.

Embodiment 2

[0036] A suspension composition containing lysozyme and florfenicol and its preparation method:

[0037] (1) Weigh 7.5 parts of lysozyme, put 15 parts of Florfenicol into an appropriate amount of water for injection, add 8 parts of Tween-80, and stir well;

[0038] (2) Add 1.6 parts of sodium citrate and stir well;

[0039] (3). Add 0.3 parts of methylparaben, and stir well;

[0040] (4) Add 15 parts of propylene glycol, fully stir;

[0041] (5) Finally, the volume is adjusted to 100 parts with water for injection, fully stirred until uniform, and homogenized twice under a pressure of 30-100Mpa.

[0042] The rotating speed is 1500 rpm, the time is 60 minutes, and the temperature is room temperature.

Embodiment 3

[0044] A suspension composition containing lysozyme and florfenicol and its preparation method:

[0045] (1) Weigh 10 parts of lysozyme, put 20 parts of Florfenicol into an appropriate amount of water for injection, add 9 parts of Tween-80, and stir well;

[0046] (2) Add 2 parts of sodium citrate and stir well;

[0047] (3) Add 0.3 part of methylparaben, fully stir evenly;

[0048] (4) Add 18 parts of propylene glycol, fully stir evenly;

[0049] (5) Finally, the volume is adjusted to 100 parts with water for injection, fully stirred until uniform, and homogenized twice under a pressure of 30-100Mpa.

[0050] The rotating speed is 1500 rpm, the time is 45 minutes, and the temperature is room temperature.

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Abstract

The invention relates to a suspension composition containing lysozyme and florfenicol, which is a microemulsion solution prepared from the lysozyme, the florfenicol, tween-80, sodium citrate, methylparaben, propylene glycol and water for injection. The composition adopts compatibility of the lysozyme and the florfenicol, not only enlarges the antimicrobial spectrum, but also has high efficiency, low toxicity, less residues and drug resistance prevention; and the prepared suspension not only can solve the problem that the florfenicol is hardly soluble in water, improves the biological utilization of the florfenicol, but also protects the activity of the lysozyme in gastrointestinal fluid, and plays a slow release effect on the lysozyme and the florfenicol to ensure that the medicament maintains long-term effective blood concentration in vivo, is integrated with instant effect, high efficiency and long action, and can be used for treating mycoplasma gallisepticum infections of livestock and poultry.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a suspension composition containing lysozyme and florfenicol and a preparation method thereof. Background technique [0002] Lysozyme is a general term for a class of enzymes that dissolve bacterial cell walls. Its antibacterial effect is to make the cell wall insoluble by destroying the β-1,4 glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine in the cell wall. Mucopolysaccharides are decomposed into soluble glycopeptides, causing the cell wall to rupture and the contents to escape and lyse the bacteria. Lysozyme can also bind to various acidic substances that induce inflammation and inactivate them. Lysozyme is clinically used for the treatment and prevention of infections and inflammations caused by various bacteria and viruses, as well as for the prevention and treatment of chronic respiratory tract and chronic bronchitis, and can also be used for non-spec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K38/48A61P31/00A61P11/00A61K31/165
Inventor 马丽伟
Owner TIANJIN RINGPU BIO TECH
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