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Hollow silver microballoon and preparation thereof as well as application method thereof in Raman detection

A silver micro and hollow technology, applied in the field of biomedicine, can solve the problems of unfavorable large-scale promotion, high cost, time-consuming, etc., and achieve the effect of simple and novel technology, less equipment, and simple materials

Active Publication Date: 2010-12-08
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although the traditional method can successfully prepare various types of microspheres, there are still some problems that need to be solved. Firstly, the preparation of the template is solved, and a layer of polyelectrolyte membrane is deposited on the template for surface modification. This traditional template-induced method requires separate Several steps to complete, time-consuming, high cost, not conducive to large-scale promotion

Method used

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  • Hollow silver microballoon and preparation thereof as well as application method thereof in Raman detection
  • Hollow silver microballoon and preparation thereof as well as application method thereof in Raman detection
  • Hollow silver microballoon and preparation thereof as well as application method thereof in Raman detection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (a) Add 0.4ml Streptococcus thermophilus with 0.02OD value into 200mL deionized water and stir at room temperature;

[0025] (b) Add 4.8 mL of 0.5M AgNO to the aqueous solution of (a) 3 aqueous solution, and stirred at room temperature for 2 hours;

[0026] (c) Add 4.8mL 0.5M AA ascorbic acid solution to (a), and continue to stir for 4 hours;

[0027] (d) Let the above solution stand overnight at room temperature, discard the supernatant, redisperse the precipitate in deionized water, sonicate for 2 hours, centrifuge at 5000 rpm for 5 minutes, and wash with deionized water and ethanol for 2 hours, respectively. times, and then placed in a 60°C oven for 2 hours.

[0028] (e) Take 1 mg of silver microspheres and add 500 microliters of different concentrations of 10 -9 The 2-mercaptopyridine aqueous solution of M was subjected to ultrasonication for 12 hours, then centrifuged and washed twice with deionized water and ethanol, and finally dispersed in 20 microliters of e...

Embodiment 2

[0031] (a) Add 0.4ml Streptococcus thermophilus with 0.02OD value into 200mL deionized water and stir at room temperature;

[0032] (b) Add 4.8 mL of 0.5M AgNO to the aqueous solution of (a) 3 aqueous solution, and stirred at room temperature for 2 hours;

[0033] (c) Add 4.8mL 0.5M AA ascorbic acid solution to (a), and continue to stir for 4 hours;

[0034] (d) Let the above solution stand overnight at room temperature, discard the supernatant, redisperse the precipitate in deionized water, sonicate for 2 hours, centrifuge at 5000 rpm for 5 minutes, and wash with deionized water and ethanol for 2 hours, respectively. times, and then placed in a 60°C oven for 2 hours.

[0035] (e) Take 1 mg of silver microspheres and add 500 microliters of different concentrations of 10 -15 The 2-mercaptopyridine aqueous solution of M was subjected to ultrasonication for 12 hours, then centrifuged and washed twice with deionized water and ethanol, and finally dispersed in 20 microliters of ...

Embodiment 3

[0037] (a) Add 0.4ml Streptococcus thermophilus with 0.02OD value into 200mL deionized water and stir at room temperature;

[0038] (b) Add 2.4 mL of 0.5M AgNO to the aqueous solution of (a) 3 aqueous solution, and stirred at room temperature for 2 hours;

[0039] (c) Add 2.4mL 0.5M AA ascorbic acid solution to (a), and continue to stir for 4 hours;

[0040] (d) Let the above solution stand overnight at room temperature, discard the supernatant, redisperse the precipitate in deionized water, sonicate for 2 hours, centrifuge at 5000 rpm for 5 minutes, and wash with deionized water and ethanol for 2 hours, respectively. times, and then placed in a 60°C oven for 2 hours.

[0041] (e) Take 1 mg of silver microspheres and add 500 microliters of different concentrations of 10 -15 The 2-mercaptopyridine aqueous solution of M was subjected to ultrasonication for 12 hours, then centrifuged and washed twice with deionized water and ethanol, and finally dispersed in 20 microliters of ...

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Abstract

The invention provides a hollow silver microballoon, preparation thereof and an application method thereof in Raman detection, belonging to the biomedical technical field. The hollow silver microballoon is prepared by mixing Streptococcus thermophilus with silver nitrate, allowing the obtained mixture to react with ascorbic acid to obtain a product, and finally precipitating and washing the product. The preparation method of the invention has simple and novel process, simple materials, a small quantity of employed equipment, low energy consumption and high detection limit up to 10-15M while detecting Raman enhancement effect; and the invention is applicable to fields such as disease detection, gas adsorption, gas masks, photochemical catalysis, food safety and the like.

Description

technical field [0001] The invention relates to a material and a method in the technical field of biomedicine, in particular to a hollow silver microsphere and its preparation and application method in Raman detection. Background technique [0002] Inorganic hollow microspheres have become one of the research hotspots in the academic circles because they can be widely used in catalysis, drug delivery, disease detection, electrochemistry and other fields. Template-induced method is the most commonly used method for preparing hollow microspheres. Various methods have been used to prepare hollow microsphere materials. For example, Y. Tang's research group used polyethylene microspheres (Chem. Commun. 2002, 350-351) as a template to prepare silver microspheres. Although the traditional method can successfully prepare various types of microspheres, there are still some problems that need to be solved. Firstly, the preparation of the template is solved, and a layer of polyelectr...

Claims

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Application Information

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IPC IPC(8): B22F9/24
Inventor 陈守慧杨大鹏崔大祥
Owner SHANGHAI JIAO TONG UNIV
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