Hollow silver microballoon and preparation thereof as well as application method thereof in Raman detection

A silver micro and hollow technology, applied in the field of biomedicine, can solve the problems of unfavorable large-scale promotion, high cost, time-consuming, etc., and achieve the effect of simple and novel technology, less equipment, and simple materials

Active Publication Date: 2010-12-08
SHANGHAI JIAO TONG UNIV
View PDF3 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the traditional method can successfully prepare various types of microspheres, there are still some problems that need to be solved. Firstly, the preparation of the template is solved, and a layer of polyelectro

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Hollow silver microballoon and preparation thereof as well as application method thereof in Raman detection
  • Hollow silver microballoon and preparation thereof as well as application method thereof in Raman detection
  • Hollow silver microballoon and preparation thereof as well as application method thereof in Raman detection

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0023] Example 1

[0024] (a) Add 0.4ml of Streptococcus thermophilus with an OD value of 0.02 to 200ml of deionized water and stir at room temperature;

[0025] (b) Add 4.8mL 0.5M AgNO to (a) aqueous solution 3 Aqueous solution and stirred at room temperature for 2 hours;

[0026] (c) Add 4.8mL 0.5M AA ascorbic acid solution to (a) and continue to stir for 4 hours;

[0027] (d) The above solution was allowed to stand overnight at room temperature, the supernatant was discarded, the precipitate was re-dispersed in deionized water, sonicated for 2 hours, centrifuged at 5000 rpm for 5 minutes, and washed with deionized water and ethanol respectively. Then place it in an oven at 60°C for 2 hours.

[0028] (e) Take 1 mg of silver microspheres and add 500 μl of different concentrations 10 -9 The 2-mercaptopyridine aqueous solution of M was subjected to ultrasound for 12 hours, and then washed twice with deionized water and ethanol by centrifugation, and finally dispersed in 20 microliters o...

Example Embodiment

[0030] Example 2

[0031] (a) Add 0.4ml of Streptococcus thermophilus with an OD value of 0.02 to 200ml of deionized water and stir at room temperature;

[0032] (b) Add 4.8mL 0.5M AgNO to (a) aqueous solution 3 Aqueous solution and stirred at room temperature for 2 hours;

[0033] (c) Add 4.8mL 0.5M AA ascorbic acid solution to (a) and continue to stir for 4 hours;

[0034] (d) The above solution was allowed to stand overnight at room temperature, the supernatant was discarded, the precipitate was re-dispersed in deionized water, sonicated for 2 hours, centrifuged at 5000 rpm for 5 minutes, and washed with deionized water and ethanol respectively. Then place it in an oven at 60°C for 2 hours.

[0035] (e) Take 1 mg of silver microspheres and add 500 μl of different concentrations 10 -15 The 2-mercaptopyridine aqueous solution of M was subjected to ultrasound for 12 hours, and then washed twice with deionized water and ethanol by centrifugation, and finally dispersed in 20 microliters ...

Example Embodiment

[0036] Example 3

[0037] (a) Add 0.4ml of Streptococcus thermophilus with an OD value of 0.02 to 200ml of deionized water and stir at room temperature;

[0038] (b) Add 2.4mL 0.5M AgNO to (a) aqueous solution 3 Aqueous solution and stirred at room temperature for 2 hours;

[0039] (c) Add 2.4mL 0.5M AA ascorbic acid solution to (a) and continue to stir for 4 hours;

[0040] (d) The above solution was allowed to stand overnight at room temperature, the supernatant was discarded, the precipitate was re-dispersed in deionized water, sonicated for 2 hours, centrifuged at 5000 rpm for 5 minutes, and washed with deionized water and ethanol respectively. Then place it in an oven at 60°C for 2 hours.

[0041] (e) Take 1 mg of silver microspheres and add 500 μl of different concentrations 10 -15 The 2-mercaptopyridine aqueous solution of M was subjected to ultrasound for 12 hours, and then washed twice with deionized water and ethanol by centrifugation, and finally dispersed in 20 microliters ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Concentrationaaaaaaaaaa
Login to view more

Abstract

The invention provides a hollow silver microballoon, preparation thereof and an application method thereof in Raman detection, belonging to the biomedical technical field. The hollow silver microballoon is prepared by mixing Streptococcus thermophilus with silver nitrate, allowing the obtained mixture to react with ascorbic acid to obtain a product, and finally precipitating and washing the product. The preparation method of the invention has simple and novel process, simple materials, a small quantity of employed equipment, low energy consumption and high detection limit up to 10-15M while detecting Raman enhancement effect; and the invention is applicable to fields such as disease detection, gas adsorption, gas masks, photochemical catalysis, food safety and the like.

Description

technical field [0001] The invention relates to a material and a method in the technical field of biomedicine, in particular to a hollow silver microsphere and its preparation and application method in Raman detection. Background technique [0002] Inorganic hollow microspheres have become one of the research hotspots in the academic circles because they can be widely used in catalysis, drug delivery, disease detection, electrochemistry and other fields. Template-induced method is the most commonly used method for preparing hollow microspheres. Various methods have been used to prepare hollow microsphere materials. For example, Y. Tang's research group used polyethylene microspheres (Chem. Commun. 2002, 350-351) as a template to prepare silver microspheres. Although the traditional method can successfully prepare various types of microspheres, there are still some problems that need to be solved. Firstly, the preparation of the template is solved, and a layer of polyelectr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): B22F9/24
Inventor 陈守慧杨大鹏崔大祥
Owner SHANGHAI JIAO TONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap