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Potassium glycyrrhizinate preparation method

A technology of potassium glycyrrhizinate and licorice, which is applied in the field of medicine and chemical industry, and achieves the effects of good stability, easy promotion and strong practicability

Active Publication Date: 2010-12-29
JIANGSU TIANSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The technology provided by the invention is novel, easy to operate, energy-saving and environmentally friendly, and has good practicability. At present, there is no relevant patent or literature report

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Take 5 kg of monoammonium glycyrrhizinate with a content of 75%, add 35 L of water and dissolve at 45° C. to obtain monoammonium glycyrrhizinate solution.

[0028] Take the monoammonium glycyrrhizinate solution, and pass it through a HP-20 macroporous adsorption resin column. After loading the column, add water to fully elute to remove other impurities, and then use 31 L of potassium carbonate solution with a concentration of 1.0% to elute, and collect The eluate was concentrated to 10 L under reduced pressure to obtain a monopotassium glycyrrhizinate concentrate.

[0029] Take the concentrated solution, add it to 20L ethanol solution, stir, let stand to crystallize, filter, and dry to obtain 4.2kg of glycyrrhizic acid monopotassium salt.

Embodiment 2

[0031] Take 10 kg of diammonium glycyrrhizinate with a content of 98%, add 70 L of water and dissolve at 50°C to obtain a diammonium glycyrrhizinate solution.

[0032] Take the diammonium glycyrrhizinate solution and pass it through the ion exchange resin column of model D301. After the column is loaded, add water to fully elute to remove other impurities, then use 130L of potassium hydroxide solution with a concentration of 0.5% to elute, collect and elute solution, concentrated under reduced pressure to 18L to obtain dipotassium glycyrrhizinate concentrate.

[0033] Take the concentrated solution, add it to 36L ethanol solution, stir, let stand to crystallize, filter, and dry to obtain 9.7kg of dipotassium glycyrrhizinate.

Embodiment 3

[0035] Take 5 kg of monoammonium glycyrrhizinate with a content of 90%, add 30 L of water and dissolve at 40° C. to obtain monoammonium glycyrrhizinate solution.

[0036] Take the monoammonium glycyrrhizinate solution, and pass it through a HPD-100 macroporous adsorption resin column. After loading the column, add water to fully elute and remove other impurities, and then use 60 L of potassium hydroxide solution with a concentration of 1.0% to elute. The eluate was collected and concentrated under reduced pressure to 7.5 L to obtain dipotassium glycyrrhizinate concentrate.

[0037] Take the concentrated solution, add it to 15L ethanol solution, stir, let stand to crystallize, filter, and dry to obtain 4.6 kg of dipotassium glycyrrhizinate.

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PUM

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Abstract

The invention provides a potassium glycyrrhizinate preparation method, mainly comprising the processes of dissolution, column chromatography, ion exchange and crystallization. The preparation process of the invention has good repeatability, the obtained potassium glycyrrhizinate has low cost and reliable and controllable quality, and the preparation method is suitable for industrialized production.

Description

technical field [0001] The invention discloses a method for preparing potassium glycyrrhizinate, which belongs to the field of medicine and chemical industry. Background technique [0002] Licorice is the root and rhizome of Glycyrrhiza uralensis Fisch., Glycyrrhiza in flataBat., or Glycyrrhiza glabra L., a leguminous plant. It is mainly produced in Inner Mongolia, Xinjiang, Gansu and other places. Licorice has a long history of being used as medicine, and "Shen Nong's Materia Medica" listed it as the best medicine, and ancient medical scientists honored it as "the old man of the country". Because of its precious resources, it is listed as the second-class national protected wild medicinal material by the country. [0003] The main component of licorice is glycyrrhizin, also known as glycyrrhizic acid, because of its sweetness, also known as glycyrrhizin. With the in-depth research on the effects of glycyrrhizic acid on anti-virus, anti-inflammation, and liver protection, ...

Claims

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Application Information

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IPC IPC(8): C07J63/00C07H15/256C07H1/00
Inventor 杨永安
Owner JIANGSU TIANSHENG PHARMA
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