Composition for stimulating natural killer cell activity

A composition and application technology, applied in the direction of drug combination, organic active ingredients, allergic diseases, etc., can solve the problem of natural killer cells being affected

Inactive Publication Date: 2010-12-29
NV NUTRICIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Did not show an effect on natural killer cells

Method used

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  • Composition for stimulating natural killer cell activity
  • Composition for stimulating natural killer cell activity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1. Stimulation of NK cell activity in HIV patients using the fiber mixture of the invention.

[0048] Treatment options for HIV patients

[0049] design :

[0050] This study tested the dose-response effect of a fiber mixture on NK cell activity in a randomized, double-blind, parallel-group design with placebo as the control.

[0051] The study duration for each patient was 16 weeks from the baseline visit, of which 12 weeks were the dosing period. Screening visits were performed at baseline and at 4, 12, and 16 weeks after baseline.

[0052] Research purposes :

[0053] The objectives were to determine the tolerability, safety, and establishment of immunomodulatory effects of daily oral supplementation for 12 weeks in asymptomatic HIV seropositive adults.

[0054] Provided research product NR100063 is in powder form in individual sachets, and each sachet contains 16 grams. The powder is composed of galacto-oligosaccharides (scGOS), fructo-oligosaccha...

Embodiment 2

[0071] Example 2. Stimulation of NK cell activity in fast-aging mice

[0072] To investigate the effect of fiber on NK cell activity in aged mice, NK cell activity was measured in splenocytes of 8-month-old rapidly aging SAMP8 mice that received different doses of scGOS, lcFOS, and Acidic oligosaccharides from pectin hydrolysates. Animals were aged on standard rodent chow and received supplemental or control diets for the final 43 days ("treatment regimen").

[0073]NK cell activity was measured by a modified "JAM" assay. The method is described by P. Matzinger in JAM Test. A simple assay for DNA fragmentation and cell death (A simple assay for DNA fragmentation and cell death. J Immunol Methods. 1991 Dec 15; 145(1-2): 185-92) was used and improved and instructions are described here. Yac-1 cells were used as target cells, labeled with 2.5 microCurie / ml tritiated thymidine (Perkin Elmer, Groningen, the Netherlands) for 4-6 hours, and seeded at 5000 cells / well in a round-bo...

Embodiment 3

[0078] A preferred composition useful for stimulating NK cell activity in the elderly may comprise:

[0079] Protein 24.9 Energy %

[0080] 20% whey

[0081] 80% casein

[0082] Carbohydrates 38.9 energy %

[0083] Fat 36.2 energy %

[0084] Dietary fiber 2.3g / 100ml

[0085] FOS 0.8g / 100ml

[0086] Galactooligosaccharide 0.8g / 100ml

[0087] inulin

[0088] Vitamins according to FSMP regulations

[0089] Minerals according to FSMP regulations

[0090] Trace elements according to FSMP regulations

[0091] Energy density between 1 and 2kcal / ml

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Abstract

The present invention relates to a nutritional composition comprising dietary fibre for stimulating natural killer cell activity, in particular in patients infected with HIV, oncology patients and elderly.

Description

technical field [0001] The present invention relates to a nutritional composition and its use for stimulating the activity of natural killer cells (NK cells). Background technique [0002] Decreased NK cell activity is an important symptom of disease progression in cancer patients, HIV-infected patients, and elderly and surgical patients. [0003] Natural killer (NK) cells are generally defined by their ability to lyse certain tumor cells as well as virus-infected cells in a non-specific and non-histocompatibility-limited manner. In addition to regulating hematopoiesis, NK cells also have certain activities against bacteria, fungi and parasites. Morphologically, human NK cells are classified as large granular lymphocytes. Phenotypically, they express a variety of specific membrane-associated molecules and receptors, among which CD56 (NCAM) and CD16 are most commonly used for identification and enumeration. NK cells are thought to provide the basic defense against viral in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198A61K31/702A61K31/732A61P31/18A61P35/00
CPCA61K31/732A61K31/702A61K31/198A61P31/12A61P31/18A61P35/00A61P37/04A61K2300/00
Inventor A·J·M·弗里斯玛A·L·B·范海佛特A·P·沃斯B·佩特派尔-范特兰德
Owner NV NUTRICIA
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