46 results about "Oncology patients" patented technology

The invention belongs to preparation of biological cell formulations, and in particular relates to a preparation method of dendritic cell (DC) vaccine loaded with autologous tumor associated holoantigen. The preparation method comprises the following steps: preparing the autologous tumor associated holoantigen, collecting and separately culturing DCs, impacting the DCs by the autologous tumor associated holoantigen, maturing the DCs and preparing autologous tumor antigen specific DC vaccine. The invention solves the problems in the prior art that the immunogenicity of tumor antigen is not strong enough, the antigen target spots are incomplete, the tumor antigens of most tumor patients are difficult to acquire, and the like. The DC vaccine provided by the invention has the advantages of effectively inducing tumor antigen specific cytotoxic T lymphocyte (CTL) in vitro and in vivo, efficiently generating specific cytotoxicity on tumors, having high overall effective rate and no obvious toxic side effects in clinical application, and the like.

Disclosed is a novel preparation of Thymosin alpha-1, which comprises Thymosin alpha-1, medicinal adjuvant and water for injection. The prepared Thymosin alpha-1 injection can be used as an immunity enhancement medicament for the treatment of chronic hepatitis B (HBV), hepatitis C (HCV), hepatocytecancer, melanocarcinoma, infectious disease, self-immune disease and malignant tumor.

The present invention relates to a nutritional composition comprising dietary fibre for stimulating natural killer cell activity, in particular in patients infected with HIV, oncology patients and elderly.

The technical scheme of the invention provides a gene chip for predicting liver cancer metastasis and recurrence risk, which comprises a substrate and a probe arranged on the substrate, wherein the probe consists of 149 genes. The gene chip for predicting the liver cancer metastasis and the recurrence risk has the advantages that: due to the adoption of genome comparison research, a large sample independently proves that a prediction model can accurately predict and evaluate the metastasis potential of liver cancer patients. Therefore, postoperative survival and metastasis, and recurrence of the patient can be accurately predicted (even early liver cancer patients can be accurately predicted). The gene chip contributes to early identifying or predicting high-risk patients so as to perform intensive monitoring and effective intervention on the high-risk patients to further prolong the life of the tumor patients.

The invention relates to a culturing method for body fluid derived tumor cells and a tumor medium. The method comprises the steps of enriching body fluid tumor cells; mixing the body fluid tumor cellswith an extracellular matrix; and in the presence of a basic medium, adding corresponding pleural effusion, ascites or cerebrospinal fluid and the like to carry out 3D cell culture. By the method, apatient derived tumor analog (PDTA) can be obtained effectively, and a novel detecting tool is provided for detection of sensitivity of clinical tumor patients to drugs and measurement of in-vitro metabolic stability, metabolic profiling, toxicity and the like of drug candidates.

The invention discloses an immunity enhancing reagent comprising AAVs carrying molecule encoding genes of antibodies at immunodetection points, wherein the immunodetection points are one or several from PD-1, PD-L1 and CTLA-4. The AAVs carrying the molecule encoding genes of the antibodies at different immunodetection points are combined with each other, T cells, natural killer cells, cytotoxic T lymphocytes or cell factor induced killer cells and other immune cells are infected in vitro, and the antibodies at the immunodetection points are expressed and secreted after the infected immune cells are fed back to bodies of patients suffering from tumors, so that the combination of receptors at the immunodetection points and ligands of the receptors is blocked, the transfer of an immunosuppression signal is effectively blocked, the immune tumor suppression microenviroment is destroyed, the immune cell killing capacity is improved, and furthermore the curative effect of adoptive immune therapy is improved.

The invention relates to a biomarker captured on a surface matrix adsorbed with an antibody group, which is detected by a quantitative mass spectrum analysis under the control of standard quality control serum. The definition of immunomic mass spectrometry analysis, namely IMS, is a method which combines a group of various antibodies with a spectrometry to accurately identify a variant or modified biomarker group. A plurality of biomarkers can be captured on one antibody group matrix at the same time, and a spectrometry accurate analysis is processed to the captured variant or modified biomarker. The invention can detect a plurality of biomarker groups at the same time. The method of the invention can be used for detecting a biomarker combination in fluid which is separated from a human body. The biomarker combination is applicable to the detection method of a kit which identifies in vitro fluid of a normal person and patients with different types of tumours of the digestive system. The method is accurate, convenient and rapid.

The invention discloses a peripheral blood lymphocyte micronucleus detection kit and a detection method thereof. The detection kit provided by the invention comprises erythrocyte hemolysin, a red fluorescent dye solution, a lysis solution and a positive standard product, wherein the lysis solution comprises sodium chloride, sodium citrate, Triton X-114, green fluorescent dye and RNase; and a peripheral blood lymphocyte micronucleus detection method based on the kit and a flow cytometry detection method is provided. An experiment proves that the peripheral blood lymphocyte micronucleus detection kit and the peripheral blood lymphocyte micronucleus detection method are quick and accurate; on the premise of guaranteeing objective and true experimental results, the detection cost is reduced, and the experiment has repeatability and can be widely applied to clinical diagnosis and monitoring of occupational exposure genetic damage of healthy people, rehabilitation detection of genetic damage of cancer patient and cellular genetic science research.

The invention discloses a production technology of freeze-dried powder of breast milk (including colostrum) of human body, and a product and functions thereof. The production technology comprises the following steps: redundant breast milk (including colostrum) of healthy parturient women is collected; impurity removal by means of centrifugation, fat removal and pasteurization, freezing and drying at low temperature are carried out to obtain the freeze-dried powder of the breast milk (including colostrum) of human body. The freeze-dried powder can be made into tablets, capsules and oral solution; the freeze-dried powder can be adopted for supplying nutritious food required by lactation and growth for infants lack of breast feeding and teenagers in the growth stage, providing nutriments for athletes needing to create good results, personage in performing as well as film and television circles, personage succeeding in career, convalescents, subhealth crowd and crowd of various kinds of low immunity, and also can be used for curing all patients with tumors, people with AIDS, patients of organ transplantation and patients with diarrhea to speed up the recovery process of organism health, curing and avoiding exercise-induced diarrhea of athletes and improving the performance of sports; and the freeze-dried powder can further be used for anti-inflammation, sterilization and antivirus and providing special nutriments for cosmonauts, aviators and special forces.

The invention relates to a construction method and applications of targeting oncolytic-adenovirus carier Ad-TD-gene. The carrier of the oncolytic-adenouirus is Ad5, the adenovirus-5 in Subcategory C;three internal genes of the adenovirus, including E1A-CR2, E1B19K and E3gp-19K, are deleted; an E3B gene is retained, and an E3gp-19K promoter expression exogenous therapeutic gene is retained; and any antigen gene which is helpful to treating tumors or used for infectious disease vaccines can be inserted into the carrier. The Ad-TD-gene has the advantages of specificity, high safety and high efficiency, can carry various antigen genes treating tumors, and can be used for treating various solid tumors. By utilizing the human chemotactic factor CCL 21 gene as the therapeutic gene, the Ad-TD-hccL21 has the effects of tumor targeting and tumor resistance, lays foundation for introducing targeting genetic engineering medicines towards clinical applications, and provides an effective therapy for patients with tumors.

The invention discloses a traditional Chinese medicine composition for alleviating side effects of chemotherapy of a cancer patient. The composition is prepared from the following main raw materials in parts by weight: 6-12 parts of caulis bambusae in taeniam, 6-15 parts of bighead atractylodes rhizome (stirred-baked with bran), 4-8 parts of coptis chinensis, 6-12 parts of salviae miltiorrhizae, 5-12 parts of rhizoma bletillae, 3-6 parts of rheum officinale, 5-11 parts of horsetail, 6-12 parts of mangnolia officinalis, 3-6 parts of indigo naturalis, 4-8 parts of rhizoma cyperi (processed with vinegar), 6-18 parts of myrrh, 6-12 parts of costus roots, 9-15 parts of chorion ovi, 4-9 parts of carpesium abrotanoides and 4-12 parts of ginger processed pinellia. The composition disclosed by the invention further has the good effects that according to principle of traditional Chinese medicine and physical and mental characteristics of the cancer patient, the composition can effectively alleviate the side effects of chemotherapy; the materials selected are traditional Chinese medicinal materials which are free from any toxic and side effects.

The invention provides an oncology department nursing device. The oncology department nursing device comprises a nursing bed body, wherein supporting legs are arranged at the bottom of the nursing bedbody; universal wheels are arranged at the bottoms of the corresponding supporting legs; a translation track is formed in the outer edge side of the nursing bed body; a driving device is arranged onthe translation track; an isolation device is mounted on the translation track through the driving device; a control device is arranged at the top of the isolation device; the control device comprisescontrol buttons; a display screen is arranged on one side of the control device; an air purifier is further arranged in the isolation device; and the display screen and the air purifier are electrically connected with the control device. The oncology department nursing device is novel in design, good in nursing effect and beneficial to rehabilitation of tumor patients.

The invention provides a minimally-invasive detection kit for a serum miRNA combination. The kit uses miR-626, miR-1537-3p, miR-4286 and miR-5100 as molecular markers for oral squamous cell carcinomain a combined mode, and the joint expression level of the individual miR-626, miR-1537-3p, miR-4286 and miR-5100 is judged in a curve-fitting mode. The minimally-invasive detection kit is rapid in detection, convenient to detect, high in detection sensitivity and specificity, low in cost, capable of meeting the detection needs of most cancer patients and extremely wide in application range, and the forecast accuracy is high through clinical validation.

The invention relates to hericium erinaceus complex polysaccharide composition as well as a preparation method and application thereof. The hericium erinaceus complex polysaccharide composition is prepared from the following components in parts by weight: 0.5 to 5 parts of hericium erinaceus extract, 0.5 to 5 parts of agaricus blazei murill extract, 0.5 to 5 parts of poria cocos extract, and 0 to 5 parts of neutral radix notoginseng polysaccharides extract. The hericium erinaceus complex polysaccharide composition is helpful for improving the immunity of the patients with low immunity and tumor, improves the symptoms of mental malaise, body weakness, loss of appetite, nausea and vomiting, loose stool and diarrhea, dry stool, irritability and insomnia, and the like, effectively reduces the harm of radiotherapy and chemotherapy and surgery on cancer patients to extend the survival of cancer patients.

The invention relates to the technical field of cell separation, in particular to a separate culture method of primary tumor cells. A composite enzyme solution is adopted for decomposing cancer tissue, wherein collagenase, trypsin and hyaluronidase in the composite enzyme solution mutually cooperate, looseness of bridging structures among the cells can be accelerated, the cancer tissue is converted to be flocculent from being blocky, thus, the cells in cell aggregate are evenly dispersed in cell suspension, and the numbers of cell alliances and single cells suspended in cell sap are increased;after inoculated culture is completed, the cells easily adhere to walls to grow, and therefore the survival rate of the cells is increased; serum extracted from the body of a patient suffering from tumors is added into a culture medium, a microenvironment most suitable for the growth of the cancer cells is provided for the cancer cells, the culture period is shortened, the culture success rate is80% or above, and the clinic consistency rate is 95% or above.

The invention discloses a chemotherapy nursing device for a gynecological tumor patient. The chemotherapy nursing device comprises a first telescopic rod and a second telescopic rod; a connecting plate is fixed between the first telescopic rod and the second telescopic rod; fixing assemblies are arranged at the lower end of the first telescopic rod and the lower end of the second telescopic rod; a supporting plate is arranged between the upper end of the first telescopic rod and the upper end of the second telescopic rod; a first sliding groove and a second sliding groove are formed in the two sides of the supporting plate correspondingly; a first groove is formed in the side wall of the upper end of the first telescopic rod; a first motor is fixed in the first groove; a square block slidably arranged in the first sliding groove is fixed to an output shaft of the first motor; a second groove is formed in the side wall of the second telescopic rod; a second motor is fixed in the second groove; a first gear is fixed to an output shaft of the second motor; a rack meshed with the first gear is fixed into the second sliding groove; a protective cover is arranged on one side of the supporting plate; a first sliding groove and a second sliding groove are formed in the supporting plate; and a first inserting block and a second inserting block are fixed to the protective cover and arranged in the first sliding groove and the second sliding groove in a sliding mode correspondingly. The chemotherapy nursing device has the advantages of fixing hands of the patient and preventing external injury.

The invention provides a chemotherapy nursing device for gynecological tumor patients. The chemotherapy nursing device for the gynecological tumor patients comprises a base, a moving mechanism, an arc-shaped frame, a beating assembly, a reciprocating mechanism, a fixing assembly and a locking assembly, supporting tables are fixedly installed on the two sides of the top of the base, a first motor is fixedly installed on the side wall of a supporting plate, a lead screw is fixedly installed at the output end of the first motor, and a sliding block is slidably connected into a moving groove; an arc-shaped block is slidably connected into the arc-shaped groove, one end of the push rod is slidably connected with the bottom of the box body, the reciprocating mechanism is installed in the box body, the fixing assembly is installed on the top of the supporting table, and the locking assembly is installed on the arc-shaped frame. The chemotherapy nursing device for the gynecological tumor patients has the advantages that numb arms of the patient can be automatically beaten and massaged to relieve numb, and all parts of the arms can be evenly and comprehensively massaged.

A health-care food suitable for the patients of tumor, AIDS, rheumatoid arthritis, intestinal ulcer, etc to improve their immunity is prepared from chitosan (7.5-9 Wt portions), wall-broken ganoderma spore powder (0.5-1.5) and cordyceps (0.5-1).

The invention relates to the technical field of nursing devices, and discloses a gynecological tumor patient chemotherapy nursing device which comprises a bottom plate, the bottom plate is of a hollow cuboid structure, penetrating through grooves are formed in the two sides of the upper surface of the bottom plate, moving blocks are slidably connected to the interiors of the through grooves, sliding rods are fixedly connected to the two sides of the bottom plate, lower fixing blocks are connected to the outer side walls of the sliding rods in a sliding mode, and the opposite sides of the two lower fixing blocks are attached to the two sides of the bottom plate respectively. When in use, the device is placed at a corresponding position through the bottom plate, arms are placed between the bottom plate and the arc-shaped mounting plate, the arc-shaped mounting plate can enlarge the space between the arc-shaped mounting plate and the bottom plate through a telescopic groove formed in the arc-shaped mounting plate and an arc-shaped telescopic plate sliding in the arc-shaped mounting plate, arms with different thicknesses can be conveniently placed in the space, and the arc-shaped mounting plate can slide in the through groove through the moving blocks, so that the massage position can be conveniently changed.

The invention discloses a medicament for relieving radiation side reactions of cancer patients. The medicament is prepared from the following main raw materials in parts by weight: 3-12 parts of codonopsis pilosula, 6-15 parts of rhizoma atractylodis macrocephalae (stir-baked with bran), 2-6 parts of radix paeoniae alba, 6-12 parts of salviae miltiorrhizae, 5-12 parts of rhizoma bletillae, 3-6 parts of rheum officinale, 5-11 parts of syzygium aromaticum, 3-6 parts of indigo naturalis, 4-8 parts of rhizoma cyperi (processed with vinegar), 3-9 parts of liquorice, 6-12 parts of costus roots, 4-8 parts of smoked plum, 3-8 parts of resurrection lily rhizome and 4-12 parts of ginger processed Pinellia. The materials selected by the medicament are traditional Chinese medicinal materials which are free from any toxic and side effects. Medicine sources are easily available and medicinal materials are low in cost and burden is not caused to the patient.

The invention discloses a medicine for relieving radiotherapy reactions of cancer patients. The medicine is mainly prepared from the following raw materials in parts by weight: 3-12 parts of codonopsis pilosula, 6-15 parts of bighead atractylodes rhizome (stir-baked with bran), 2-6 parts of radix paeoniae alba, 6-12 parts of salvia miltiorrhiza, 5-12 parts of bletilla striata, 3-6 parts of rheum officinale, 5-11 parts of clove, 3-6 parts of indigo naturalis, 4-8 parts of nutgrass galingale rhizome (stir-baked with vinegar), 3-9 parts of liquorice, 6-12 parts of costus root, 4-8 parts of dark plum, 3-8 parts of resurrection lily rhizome and 4-12 parts of ginger processed pinellia. The medicine disclosed by the invention is completely made from traditional Chinese medicines, and is free from toxic and side effects; and moreover, the medicine is easily available in medicine source, low in medicinal material cost and free from burden on patients.

The invention discloses a traditional Chinese medicine preparation for a patient suffering from pancreatic cancer to take after an operation. The traditional Chinese medicine preparation is prepared from raw materials in parts by weight as follows: 8-13 parts of spreading hedyotis herbs, 3-7 parts of water chestnuts, 6-12 parts of roots of symplocos sumuntia, 9-13 parts of roots of redfruit actionodaphne, 7-14 parts of flowers of fleshfingered citron, 5-10 parts of fructus livistonae, 8-12 parts of garden burnet roots, 6-13 parts of giant knotweed rhizomes, 4-9 parts of Japanese st. john's wort herbs, 3-6 parts of roots of Hongkong caper, 7-12 parts of herbs of smallflower beggarticks, 5-11 parts of leaves or roots of littlefruit uvaria, 8-14 parts of roots of evans begonia, 6-11 parts of dragonhead herbs and 4-12 parts of herbs of corymb woodsorrel. The traditional Chinese medicine preparation has the excellent effects as follows: a prepared medicine has remarkable advantages in promotion of postoperative rehabilitation of the patient suffering from pancreatic cancer, reduction of operative complications, improvement of immunity, prolonging of lifetime and the like; the medicine is scientifically matched, has a good treatment effect and is free of side effects, and the burden of the patient can be effectively reduced due to low treatment expenses.

The invention discloses a preparation having the synergistic effect and for oncology patients to take during the radiation therapy, and a preparation method thereof. The preparation is prepared by the following main raw materials in weight ratio: 5-10 of Bacopa monnieri Wettst, 4-7 of the stem of Abrus precatorius L, 8-12 of Cucubalus baccifer, 10-15 of goldfussia psilostachys, 4-9 of curcuma aromatica, 3-8 of Iris confuse, 5-9 of viburnum sargenti, 6-10 of cabbage, 4-8 of berchemia lineate, 9-14 of I.noli-tangere, 5-11 of Patrinia heterophylla, 6-10 of Halenia corni, 10-15 of Gentiana filistyla Balf.f.et Forrestex Marq, and 6-10 of urena lobata. The preparation relieves the pain of patients, effectively prolongs the survival time of patients, improves the quality of life, significantly reduces the toxic and side effects in combination with the radiotherapy, and facilitates the smooth completion of the radiotherapy. The preparation has the synergistic effect on radiotherapy.

The invention belongs to the field of traditional Chinese medicines, and relates to a composition for improving or treating acute radioactive oropharyngeal mucositis and a preparation method and application thereof. The composition for improving or treating the acute radioactive oropharyngeal mucositis has the effects of improving or treating discomfortable symptoms of acute stage reaction of the oropharyngeal mucositis such as dryness and pain of oropharynx, red and swelling, erosion, ulcer and the like caused by radiation chemotherapy. The composition for improving or treating the acute radioactive oropharyngeal mucositis is characterized by being prepared from the following crude drugs by weight proportion: 12-18 parts of rhizoma phragmitis, 8-12 parts of flos lonicerae, 12 to 18 parts of fructus momordicae, 7 to 12 parts of herba menthae, 1 to 3 parts of endothelium corneum gigeriae galli, and 3 to 8 parts of auricularia polytricha or white fungus. The composition for improving or treating the acute radioactive oropharyngeal mucositis has the effects of nourishing Yin and generating body fluid, diminishing inflammation, reducing phlegm, increasing appetite, greatly improving the discomfortable symptoms of the acute stage reaction of the oropharyngeal mucositis such as the dryness and pain of oropharynx, the red and swelling and the like, and being suitable for patients with head and neck cancer in the period of radiotherapy and chemotherapy to drink. In particular, the composition for improving or treating the acute radioactive oropharyngeal mucositis is prepared as a solid beverage of the traditional Chinese medicine, and has the advantages of being convenient to brew, good in taste and simple in production process.

The invention discloses application of LINC00167 in preparation of a medicine for inhibiting tumor angiogenesis, and belongs to the technical field of biological medicine. The LINC00167 is an lncRNA closely related to ionizing radiation stimulation, the expression level of the LINC00167 is remarkably increased after X-ray irradiation, and the expression level is higher and higher along with the prolonging of the time after irradiation. Meanwhile, the expression level of the LINC00167 is positively correlated with the tumor angiogenesis level, which means that the LINC00167 can play a key role in the response process of the tumor to radiation stimulation; by utilizing the point, the high expression of the LINC00167 after irradiation can be artificially inhibited, so that the same effect as that of a clinically common vascular inhibitor is achieved, the prognosis of tumor patients after radiotherapy is improved, and the recurrence probability of tumors is reduced.

The invention discloses a nursing medicament for relieving cancer patient chemotherapy side reactions. The medicament is prepared from, by weight, 8-14 parts of centella, 6-9 parts of tremmella, 9-15 parts of rehmannia glutinosa, 5-10 parts of polygonum multiflorum, 4-11 parts of hawthorn fruits, 7-13 parts of saussurea involucrate, 6-15 parts of lotus seeds, 6-9 parts of medical stone, 1-5 parts of corn and 1-9 parts of bunge cherry seeds. According to the medicament, the channel affinity medicine with the high spicy passing effect is selected, the medicine directly acts on an effected part, main and collateral channels are transferred, the effects of improving immunity, enhancing appetite and relieving pain are achieved, and the medicament can be used for relieving cancer patient chemotherapy side reactions such as diarrhea, alopecia and fatigue.