12results about How to "Relieve aging" patented technology

The invention mainly relates to composite hydrogel of a targeted cartilage end plate as well as a preparation method and application of the composite hydrogel, and belongs to the technical field of biological medicines. The composite hydrogel of the targeting cartilage end plate comprises a cartilage targeting peptide modified drug-loaded exosome, calcium carbonate, chitosan and water, and the cartilage targeting peptide modified drug-loaded exosome comprises an exosome, a cartilage targeting peptide and salvianolic acid A. The composite hydrogel of the targeting cartilage end plate is prepared by the following steps: encapsulating salvianolic acid A by exosome derived from human mesenchymal stem cells, modifying by cartilage targeting peptide to obtain drug-loaded exosome modified by the cartilage targeting peptide, and mixing the drug-loaded exosome with calcium carbonate, chitosan and water. The compound can be used for accurately targeting cartilage endplate cells (CEPCs), remarkably relieving the inflammation of the CEPCs, changing the secretion phenotype of the CEPCs, delaying the senescence of nucleus pulposus cells (NPCs), relieving the inflammation of the NPCs and effectively treating intervertebral disc diseases.

The application discloses application of ginsenoside Rb1 in preparation of biological products for improving liver aging and abnormal lipid metabolism. The application research finds that ginsenoside Rb1 (20 mg / kg) can significantly improve the aging phenotype and lipid metabolism disorder of the aging liver through multi-target synergistic effect, and the mechanism is related to inhibition of lipid synthesis, improvement of lipid transport and promotion of lipid oxidation. The application provides a new drug candidate and action mechanism for intervention of aging-related liver diseases such as MASLD / MASH, and has an important clinical application prospect.

This invention provides a method, system, and medium for channel prediction in a massive MIMO TDD system using a base-extended extrapolation model. The method includes: modeling the uplink channel using a base-extended model, representing the uplink channel as a small number of unknown BEM coefficients, and reconstructing the uplink channel by estimating these unknown BEM coefficients; representing the estimated uplink channel as a linear combination of a discrete ellipsoidal BEM and its corresponding coefficients to reduce the complexity of downlink channel prediction; predicting the coefficients of a downlink time-varying DPS-BEM, and using the predicted DPS-BEM coefficients for downlink channel recovery. This invention alleviates the channel aging problem in massive MIMO TDD systems.

The utility model discloses an online purification and regeneration device for fan gear oil. The online purification and regeneration device comprises a gear oil tank, an oil inlet pipeline assembly, a filtering module, a coalescence dehydration module, a first oil pump, an oil return pipeline assembly, a gear oil regeneration module and a regeneration pipeline assembly, the gear oil tank is sequentially connected with an oil inlet pipeline assembly, a filtering module, a coalescence dehydration module and a first oil pump, one end of the first oil pump is connected with two paths, and one path is connected with the gear oil tank through an oil return pipeline assembly to form a loop; and the other path is connected with a gear oil regeneration module and a regeneration pipeline assembly, and the regeneration pipeline assembly is connected with the gear oil tank to form a loop. The device has the beneficial effects that particulate matters and water in oil are removed at the same time, the gear oil regeneration module is additionally arranged, so that the preliminary regeneration of aged oil products can be realized, the problem of aging of the fan gear oil can be effectively relieved, and the oil change cost is reduced. The device is connected to the outer side of the gear oil tank in parallel, an oil regeneration loop is connected with a normal oil return pipeline in parallel, online purification and regeneration can be achieved, use is flexible, and operation is easy.

The invention belongs to the technical field of medicines, and particularly provides a novel application of methyl cedryl ether in preparation of a product for resisting skin photoaging. Cell experiment evaluation proves that the methyl cedryl ether has no obvious influence on the activity of dermal Hs68 fibroblasts at the concentration of 12.5-100 mu M, and meanwhile, the methyl cedryl ether can obviously increase the content of hyaluronic acid in light-aged Hs68 cells induced by medium-wave ultraviolet rays (UVB), improve the mRNA expression level of COL1A2 and COL3A1, improve the mRNA expression level of HAS1 and HAS3 and reduce the mRNA expression level of MMP-1, MMP-3 and MMP-9. Therefore, the methyl cedryl ether provided by the invention can be applied to preparation of products for resisting skin photoaging.

The present invention relates to the field of copper foil technology, specifically to an integrated device for copper foil gluing and drying, which solves the problem that the glue roller of the equipment will inevitably be stained with glue, and if the stained glue solidifies, it will affect the gluing operation of the equipment, and the glue applied to the copper foil will lose water in hot weather, thereby gradually hardening and reducing its viscosity. It includes a copper foil gluing and drying integrated machine. The present invention uses a residual glue cleaning and maintenance mechanism to enable the rubber roller cleaning ring and the maintenance ring cotton that absorbs maintenance oil to move and rotate on the outer surface of the glue roller. At the same time, some anti-aging agents can be mixed on the glue surface of the copper foil through a glue surface processing mechanism. Through the above technical solution, the glue solidified on the outer surface of the glue roller can be automatically cleaned to prevent the solidified glue from affecting the gluing operation of the equipment, and the aging and hardening process of the glue applied to the copper foil can be alleviated by mixing the anti-aging agent in the glue surface.

The present invention discloses a Zhuangyi Linggui Qiaowu prescription for relieving vascular dementia and a preparation method thereof. The Zhuangyi Linggui Qiaowu prescription is made of a main drug, a supplementary drug and a secondary drug: the raw materials of the main drug include: ganoderma lucidum, angelica vine and centipede; the raw materials of the supplementary drug include: notoginseng, salvia miltiorrhiza, chuanxiong and calamus; the raw materials of the secondary drug include: polygala tenuifolia and arisaema cuneata. The Zhuangyi Linggui Qiaowu prescription obtained by the method of the present invention has the functions of improving cognitive impairment related to hippocampus, reducing neuronal damage in the hippocampus of the brain, and enhancing the short-term memory function of the hippocampus of the brain, thereby relieving vascular dementia caused by various cerebrovascular diseases.

The present application relates to the technical field of dissolved hydrogen and oxygen measurement, and particularly relates to a multifunctional flow cell device suitable for a hydrogen and oxygen sensor and a use method, comprising: a flow cell, comprising a cell body, the cell body is further provided with a water inlet and a water outlet; a three-way valve, comprising a near-water part, a far-water part and a side connection part, the near-water part is connected with the water inlet, the far-water part is arranged between the near-water part and the side connection part, and the far-water part is used for connecting a sampling pipeline or a drainage pipeline; a cleaning agent pool, provided with a medicament pool and a waste liquid pool, the medicament pool is connected with the water outlet, and the waste liquid pool is connected with the water inlet; a variable-diameter quick connector; and a bidirectional water pump. The variable-diameter quick connector is arranged at the water inlet and the water outlet, the specification can be quickly replaced according to the site, the size mismatching problem of the pipeline of the traditional flow cell is solved, a backwashing flow path is constructed, the sensor membrane contamination and aging problems are effectively relieved, the service life of the sensor electrode is prolonged, the personnel exposure risk is reduced, and the equipment downtime is reduced.

The invention belongs to the technical field of medicines, and particularly provides a novel application of cedryl acetate in preparation of a product for resisting skin photoaging. Cell experiment evaluation proves that the cedryl acetate has no obvious influence on the activity of dermal Hs68 fibroblasts at the concentration of 12.5-100 mu M, and meanwhile, the cedryl acetate can obviously increase the content of 1-type collagen in light-aged Hs68 cells induced by medium-wave ultraviolet rays (UVB), improve the mRNA expression level of COL3A1, improve the mRNA expression level of HAS1 and HAS2 and reduce the mRNA expression level of MMP-3 and MMP-9. Therefore, the cedryl acetate provided by the invention can be applied to preparation of products for resisting skin photoaging.

The application relates to the technical field of skin bacteriostatic liquid, and discloses a skin bacteriostatic liquid containing plant extracts and a preparation method thereof, which comprises the following raw materials in parts by mass: composite plant extracts containing nanocrystalline particles 15-20 parts, glycerol 3-4 parts, sodium hyaluronate 0.1-0.2 parts and purified water 75-85 parts. The composite plant extracts containing nanocrystalline particles, glycerol, sodium hyaluronate and purified water are mixed to obtain the skin bacteriostatic liquid, which has the advantages of strong bacteriostasis, long-acting bacteriostasis, mildness and no irritation, and can repair the skin barrier, realize long-acting skin bacteriostasis, reduce the repeated occurrence of skin inflammation, and relieve inflammatory skin aging.

This invention belongs to the field of electronic component technology, and discloses a SnTe material for a nitrogen dioxide gas sensor, its preparation process, and its application. The SnTe material is synthesized via a solvothermal method. The nitrogen dioxide gas sensor mainly consists of a gas-sensitive material and gold interdigitated electrodes. The gas-sensitive material is coated on the surface of the gold interdigitated electrodes with a coating thickness of approximately 15mm to 75mm. The gas-sensitive material is SnTe. This invention provides a simple, low-cost, safe, and controllable TMDC nanomaterial preparation scheme. Using ethanolamine as a solvent and coordinating agent, and potassium hydroxide aqueous solution as a tellurium source activator, this invention synthesizes SnTe nanomaterials in one step via a solvothermal method. The SnTe nanomaterials prepared by this invention achieve a small nanoscale size. A large number of small-sized nanomaterials can effectively increase the sufficient contact between the material and gas molecules, improving the residence rate of gas molecules on the nanomaterial surface.

The application discloses application of UFM1 protein or a coding gene thereof in preparation of a medicine for treating osteoarthritis, and belongs to the technical field of biotechnology.The application proves that knockout of UFM1 accelerates aging of human chondrocytes, overexpression of specific UFM1 protein or a coding gene thereof can relieve aging of human chondrocytes, and specific knockout of UFM1 in a mouse experimental model can accelerate osteoarthritis of the mouse, and injection of UFM1 recombinant protein into a joint cavity of the mouse can relieve osteoarthritis of the mouse.Therefore, the UFM1 protein or the coding gene thereof can be used as a drug target, and has a good prospect in screening and preparation of the medicine for treating osteoarthritis.