2-substituted benzo-[d] oxazole-5-propionic acid compound and preparation method and applications thereof

Abstract

The invention relates to a 2-substituted benzo-[d] oxazole-5-propionic acid compound and a preparation method and applications thereof in the technical field of drug chemical industry. The compound has a stronger activity restraining function on microbes, in particular to gram-positive bacteria, fungus Candida albicans, staphylococcus aureus, Methicillin-resistant Staphylococcus aureus and bacillus subtilis.

Description

technical field The present invention relates to a compound in the field of pharmaceutical chemical technology and its preparation and application method, in particular to a 2-substituted benzo[d]oxazole-5-propionic acid compound and its preparation and application. Background technique Since the discovery of penicillin in 1929, members of the antibiotic family have grown from strength to strength. Natural and semi-synthetic antibiotics, and even many newly synthesized antibacterial compounds have played a major role in helping humans fight against pathogenic microorganisms. However, in recent years, as more and more cases of microbial drug-resistant infections have gradually increased, it is imminent to develop a new type of antimicrobial agent. As early as 1981, Elamin I.Elinma et al. "Antibacterial and antifungal activities of benzimidazole and benzoxazole derivatives" on page 29 of Volume 19, No. 1 of "Antimicrobial Agents and Chemotherapy" (Antibacterial and Antifung...

AI Technical Summary

Problems solved by technology

In 2009, MichielE et al. "The thiazolidinedione ciglitzaone reduces bacterial outgrowth and early inflammation during Streptococcuspneumoniae" on page 614 of Volume 37 of Critical Care Medicine. pneumonia in mice) pointed out that troglitazone has the effect of inhibiting Streptococcus pneumoniae, but the minimum inhibitory concentration (MIC) was not given in the article

Through literature research, it is found that based on the similar structure of peroxidase proliferator-activated receptor gamma (PPARγ) agonist, there is no relevant report on the research on the development of antimicrobial drugs, so the present invention designs a class of PPARγ agonist analogs, 2 -Substituted benzo[d]oxazole-5-propionic acid compounds as a novel antimicrobial agent

Images