Nucleic acid aptamer derivative and application thereof in preparation of medicament carrier
A technology of nucleic acid aptamers and derivatives, applied in biochemical equipment and methods, microbial measurement/testing, drug combination, etc., can solve problems such as difficult chemical modification and transformation, easy to cause immune response, and limit wide application, etc., to achieve Reduced toxicity, no immune activity and toxicity, high application value effect
Active Publication Date: 2011-01-12
谭蔚泓
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The invention discloses a nucleic acid aptamer derivative and application thereof in preparation of a medicament carrier. The derivative is the single-chain DNA represented by formula (I); a nucleic acid aptamer is represented by the sequence 1 of a sequence list; and n is equal to 1 to 50. The nucleic acid aptamer derivative provided by the invention is liver cancer cell targeted, so that the nucleic acid aptamer derivative can serve as the medicament carrier for targeted administration of liver cancer cells in a human body to specifically kill the liver cancer cells and greatly reduce the toxicity of an anti-cancer medicament to the organism. The nucleic acid aptamer derivative provided by the invention can be chemically synthesized in a large scale and has the advantages of easy connection with medicament molecules, low cost, relatively low molecular weight, no immune activity or toxicity, and good stability. The prepared medicinal composition is stable. The medicinal composition (targeted medicament) provided by the invention has a strong bonding force with the liver cancer cells, can greatly reduce the toxic and side effects during chemical treatment of liver cancer and has very high application value. The formula (I) is: 5'-(CG)n-nucleic acid aptamer-3'.
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