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Use of ulinastatin in preparation of drugs for treating rheumatoid arthritis and pharmaceutical composition thereof

A ulinastatin and rheumatoid technology, applied in the field of medicinal chemistry, can solve the problems of severe clinical adverse reactions, failure to prevent disease progression, and no specific and effective treatment methods.

Inactive Publication Date: 2011-01-26
GUANGDONG TECHPOOL BIO-PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no specific and effective treatment method. Although traditional treatment can temporarily relieve the clinical symptoms and improve joint function of RA patients, it cannot prevent the progression of the disease, and the clinical adverse reactions are very serious.

Method used

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  • Use of ulinastatin in preparation of drugs for treating rheumatoid arthritis and pharmaceutical composition thereof
  • Use of ulinastatin in preparation of drugs for treating rheumatoid arthritis and pharmaceutical composition thereof
  • Use of ulinastatin in preparation of drugs for treating rheumatoid arthritis and pharmaceutical composition thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1 prepares ulinastatin dry powder injection

[0012] Take 100 million units of filtered sterilized ulinastatin aqueous solution, add 20 grams of mannitol to dissolve, adjust the pH to neutral, add water for injection to 2000 ml, add sodium chloride to adjust isotonicity, filter aseptically, and pack in 1000 pieces In a vial, freeze-dried under sterile conditions, to obtain.

Embodiment 2

[0013] Embodiment 2 prepares ulinastatin injection

[0014] Take 100 million units of ulinastatin aqueous solution sterilized by filtration, adjust the pH to neutral, add water for injection to 2000 ml, add sodium chloride to adjust isotonicity, filter aseptically, pack in 1000 vials, and obtain.

Embodiment 3

[0015] The therapeutic effect of embodiment 3 ulinastatin on rheumatoid arthritis rats

[0016] Part 1: Establishment and Scoring of Collagen-Induced Arthritis (CIA) Animal Model

[0017] Dissolve bovine type II collagen (C II) in 0.1M acetic acid to make a 2mg / ml solution, mix it with an equal volume of complete Freund's adjuvant, stir and emulsify with magnetic beads, and prepare an emulsion with a final concentration of 1mg / ml. Take 0.5ml (containing C II 0.5mg) and inject intradermally at 5 parts of the back of Wistar rats, and 10 days later intradermally inject the same dose at the base of the tail of the rats to boost the immunization once. Observe the incidence of arthritis in the rats, and score according to the degree of redness and swelling of the legs and toes of the arthritis-onset rats (grade 0-4). 0 points: no arthritis; 1 point: red spots or mild swelling; 2 points: moderate joint swelling; 3 points: severe joint swelling; 4 points: severe redness, severe dysfu...

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Abstract

The invention relates to an application of ulinastatin in the preparation of drugs for treating rheumatoid arthritis. The related drugs are derived from natural proteins which are extracted from human urine, have stable and reliable quality and few adverse reactions and can overcome the shortcomings of more side effects and the like in the traditional drugs for treating the rheumatoid arthritis. The efficacy comparison studies of rheumatoid arthritis animal models prove that the efficacy of the ulinastatin is better than an amethopterin group, and the side effects are few.

Description

technical field [0001] The present invention relates to the field of medicinal chemistry. Specifically, the present invention relates to a medicine for treating rheumatoid arthritis, in particular to an application of ulinastatin as a medicine for treating rheumatoid arthritis. Background technique [0002] Rheumatoid Arthritis (RA) is an autoimmune disease with chronic symmetric polyarthritis and bone and cartilage destruction as the main clinical manifestations. Its most notable pathological features are synovial hyperplasia, inflammatory cell infiltration, articular cartilage and bone destruction, loss of function and even disability. It is one of the diseases that seriously threaten human health. The prevalence of RA in my country is about 0.5%, which is lower than 1% to 3% in European and American countries, but it is still one of the main diseases that cause the loss of labor force and disability in my country (15 to 20 million people are disabled every year) ). So f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/57A61P19/02A61P19/04A61P29/00
Inventor 傅和亮邹春芽吴蓉蓉陈颖华明娟
Owner GUANGDONG TECHPOOL BIO-PHARMA CO LTD
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