Method for extracting tetrandrine

Abstract

The invention relates to a method for extracting tetrandrine. The method comprises the following steps of: adding alkali into high-concentration ethanol for extracting, dissolving with an acid, separating with D732 macroporous cation exchange resin, extracting with toluene, and alternately crystallizing with acetone ethanol to obtain the product. The method of the invention for producing tetrandrine has the advantages of simple operation, low cost and high purity of the product.

Description

Technical field:

[0001] The invention relates to a method for extracting tetrandrine, in particular to a process for preparing tetrandrine by adding alkali and alcohol, separating, extracting and crystallizing macroporous resin. Background technique:

[0002] Fangji, also known as Fangji, Han Fangji, and Stone Toad, is the dry root of the perennial winding vine of Fangjiaceae Stephaniatetrandra S. Moore. The main active ingredient is alkaloid, wherein the content of tetrandrine (Tetrandrine) is 0.40-1.33%.

[0003] tetrandrine

[0004] Alias: tetrandrine powder, tetrandrine, tetrandrine

[0005] Chemical name: (+)-Tetrandrine

[0006] Molecular formula: C 38 h 42 N 2 o 6

[0007] Molecular weight: 622.76

[0008] Molecular Structure:

[0009]

[0010] Ingredient classification: Bisbenzylisoquinoline alkaloids

[0011] Physical properties: Colorless needle crystal (ether), melting point 215-217°C, almost insoluble in water and petroleum ether, soluble in ether a...

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