28 results about "Acetone / Ethanol" patented technology

The invention discloses a preparation method of a vacancy coupled nano tip material for electrochemical seawater uranium extraction, which comprises the following steps: slicing foamed nickel, performing ultrasonic treatment in acetone, ethanol, pure water and a hydrochloric acid solution in sequence, thoroughly washing with pure water, and drying for later use; the preparation method comprises the following steps: dissolving a cobalt source, urea and ammonium fluoride in pure water, transferring the solution into a polytetrafluoroethylene lining, then adding treated foamed nickel, reacting in a high-pressure reactor, taking out a material, washing with pure water, and drying; and then calcining the dried flaky material, and treating with Ar plasma after calcining to obtain the vacancy-coupled nano tip material. The Co3O4 nano tip array rich in oxygen vacancies grows on the surface of the foamed nickel, an enhanced electric field on the nano tip induces OH <-> in a solution outside an electrode surface interface to be enriched, a local alkaline pH protection layer is formed, and attachment and deposition of metal salt on the surface of the electrode are reduced.

The application discloses a kind of polymer oil displacement agent for carbonate fractured-vug type reservoir and preparation method thereof, step 1, with acetone and ethanol mixed solution as solvent, N, N-dimethylpropylene diamine, diethyl ether and perfluorinated nonanoic acid are added into acetone-ethanol mixed solution, after complete reaction, chloropropene is added, continue to react, after reaction is finished, solvent is removed by evaporation, to obtain fluorocarbon cation hydrophobic monomer CF-1;Step 2, white oil, emulsifier Span80 and Tween80 with mass ratio of 35-45:1-3:1-2 are mixed uniformly to obtain oil phase;AM, sodium p-styrenesulfonate and fluorocarbon cation hydrophobic monomer CF-1 are dissolved in deionized water, sodium bisulfite is added, and stirred uniformly to obtain aqueous solution;The aqueous solution is added to the oil phase to obtain a uniform emulsion, ammonium persulfate is added, and the polymer oil displacement agent is obtained by reaction. It has higher temperature resistance and salt resistance, and greatly reduces the adsorption of carbonate reservoir on the oil displacement agent.

The invention belongs to the technical field of material surface treatment, and particularly discloses a surface treatment method for a high-purity silver evaporation material. The method comprises the following steps: carrying out ultrasonic cleaning on a high-purity silver evaporation material by using an ethanol deionized water solution; then, a roller polishing machine is used for polishing the pre-cleaned high-purity silver evaporation material; then, the polished high-purity silver evaporation material is soaked with turpentine; and then, acetone, ethyl alcohol and deionized water are sequentially used for conducting ultrasonic cleaning on the high-purity silver evaporation material soaked in the turpentine oil, and the high-purity silver evaporation material with the smooth and clean surface is obtained. According to the method, the green, nontoxic and recyclable solvent is adopted, polishing treatment is combined, residual oil stains on the surface of the evaporation material can be efficiently removed, surface defects of the evaporation material can be eliminated, the surface is smoother, the surface quality of the evaporation material is improved, and therefore the use stability and coating performance of the evaporation material are improved; the cleaning agent has the characteristics of low loss, good decontamination effect, high surface quality and recyclable solvent.

The application discloses a two-step rapid electrothermal preparation method of a nano-titanium dioxide photoanode and application thereof, and belongs to the field of new energy materials, and the preparation steps are as follows: titanium metal sheets are cut into rectangles, are sequentially cleaned with acetone, ethanol and distilled water through ultrasonic cleaning, are dried, are placed in an electrothermal device, are electrified under a voltage of 50 to 100 volts for 20 to 30 seconds, the first-step electrothermal treatment is completed, are naturally cooled, are continuously placed in the electrothermal device, are electrified again under a voltage of 50 to 100 volts for 20 to 30 seconds, the second-step electrothermal treatment is completed, and the nano-titanium dioxide photoanode is prepared.The application directly and rapidly grows the nano-titanium dioxide photoanode on the titanium metal sheets in a two-step electrothermal mode, has the characteristics of convenience and high efficiency, can greatly shorten the preparation time of the titanium dioxide photoanode, and can avoid excessive use of chemical reagents.

The invention provides a production process for improving pancreatin filtering performance, which comprises the following steps: A) planing pig pancreas into fragments, grinding, adding protease, 25% alcoholic solution, calcium chloride and xylitol, and activating to obtain an activated material; b) performing slurry-residue separation on the activated material to obtain slurry; c) heating and activating the slurry to obtain an activated material; d) settling the activated material to obtain a light phase; then adding a solvent for precipitation, standing, removing supernate, and carrying out filter pressing to obtain a filter cake; and E) granulating the filter cake, degreasing with a mixed solution, collecting a heavy phase, and drying to obtain the pancreatin with good filtering performance. Low-temperature pulp-residue separation is creatively adopted, a large number of impurities can be prevented from entering pancreatin, and the filtering performance and purity of the pancreatin are improved. Acetone and ethyl alcohol are combined for degreasing, the fat removal rate is high, and the filtering performance is greatly improved.

The invention relates to a fading detection method for fruiting bodies of tremella aurantialba in a mature period, and belongs to the technical field of edible mushroom color detection and evaluation. The method comprises the following steps: drying and crushing the tremella aurantialba sporocarp into powder; adding the crushed tremella aurantialba powder into an organic solvent of acetone and ethanol according to a material-liquid ratio of 1: 5 (w / v, g / mL), carrying out ultrasonic extraction in a dark place, and centrifuging under the condition of 8000 g to obtain a beta-carotene extracting solution; and irradiating the beta-carotene extracting solution under ultraviolet light for different times, substituting each measured absorbance into the beta-carotene standard curve to obtain the content of the beta-carotene, calculating the degradation amount of the beta-carotene, and measuring the fading condition of the tremella aurantialba. According to the method, the factors causing the color fading of the tremella aurantialba sporocarp and the color fading detection method are put forward for the first time, the detection method is simple, convenient, safe and efficient, guarantee is provided for rapid evaluation of the commodity value of the tremella aurantialba, and meanwhile an important foundation is laid for further development of a tremella aurantialba sporocarp color protection technology.

This invention provides a method for preparing cadmium-removing functionalized oyster shell material and its product. The method comprises the following steps: (1) Oyster shells are soaked in dilute hydrochloric acid and sodium hydroxide solution, then washed with water, dried in a drying oven, cooled, and ground into 100-120 mesh oyster shell powder (OS) for later use; (2) A certain amount of oyster shell powder is weighed, and 3-mercaptopropyltriethoxysilane (MPTES) is added dropwise at 50-130°C using toluene as the reaction solvent. After the reaction is completed by magnetic stirring and reflux, the powder is thoroughly washed with acetone and ethanol, and dried in a vacuum drying oven to obtain mercapto-functionalized oyster shell material (MPTES-OS). The preparation method of this invention has a short cycle and fewer steps, making it more practical. This invention is the first to use MPTES to modify oyster shells with mercapto groups. The prepared product improves the cadmium removal efficiency of the material, and the material also has good stability and reusability, providing more material options for cadmium removal.

A method for increasing lignocellulosic carbon microporous and mesoporous based on solvent permeation, characterized by comprising the following steps: cutting wood into thin slices of a predetermined size, and performing thermal modification; soaking the wood slices pre-carbonized in step 1) in a polar solvent for 6-10 hours, and ultrasonic oscillation; the polar solvent includes acetone, ethanol, petroleum ether, ethyl acetate, methanol and water; soaking the slices treated in step 2) in a polar solvent for 8-20 hours; drying; calcining the dried wood slices in a protective atmosphere to form lignocellulosic carbon. In the present application, the cellulose / hemicellulose in the cell wall is initially pyrolyzed by thermal modification to form a cutin layer, and then the porosity of the thermal modified wood cell wall is improved by the similar phase solubility and permeation of the polar small molecule solvent, and finally the microporous / mesoporous volume of the wood-derived carbon cell wall is simply and efficiently improved.

The invention discloses a preparation method of a purple phosphorus array silver composite surface enhanced Raman scattering substrate and bacterial detection application of the purple phosphorus array silver composite surface enhanced Raman scattering substrate. The preparation method is characterized by comprising the following steps: cutting graphite paper into small pieces, sequentially cleaning with acetone, ethanol and deionized water, and carrying out vacuum drying for 2-12 hours; putting 50-1000mg of red phosphorus fine powder, 5-100mg of iodine and 2-20cm < 2 > of graphite paper into a quartz tube, performing vacuum sealing, putting the quartz tube into a tubular furnace, heating to 650 DEG C to gasify red phosphorus, reducing the temperature to 240-480 DEG C, and continuously reacting for 2-24 hours to obtain graphite paper on which a purple phosphorus array grows; the step of preparing the silver composite surface enhanced Raman scattering substrate of the purple phosphorus array by controllably coating silver nanoparticles on the surface of the purple phosphorus array through light-induced in-situ reduction has the advantages that a Raman signal is remarkably enhanced, the detection limit of bacteria is favorably reduced, and high-sensitivity detection is realized.

The invention provides an SEM sample preparation method for micro-nano sample morphology characterization. According to the SEM sample preparation method, the adopted solvent is at least one of acetone, ethanol and methanol, and the solvents are liquid with low tension, low boiling point, high vapor pressure and low viscosity; the included angle between the conductive substrate and the horizontal plane is 15-45 degrees; the rapid evaporation effect is achieved by using specific solvents such as acetone, ethanol and methanol, and the micro-nano sample can be uniformly distributed on the conductive substrate in a manner of dropwise adding the dispersion liquid to the surface of the conductive substrate which is obliquely placed at an included angle of 15-45 degrees, so that the coffee ring effect is avoided, and the uniformity and integrity of the surface structure of the micro-nano sample are ensured. The method reduces the particle aggregation of the micro-nano sample, improves the surface quality of the micro-nano sample, is suitable for high-resolution morphology observation, can present a clearer and finer micro-nano structure especially in SEM, AFM and other characterization, and is beneficial to accurate analysis of the structural characteristics of the micro-nano sample.

The invention discloses a preparation method of a purple phosphorus array silver composite surface-enhanced Raman scattering substrate and its application in bacteria detection. The invention is characterized by comprising the steps of cutting graphite paper into small pieces, washing them with acetone, ethanol and deionized water in sequence, and vacuum drying them for 2-12 hours; placing 50-1000 mg of red phosphorus fine powder, 5-100 mg of iodine and 2-20 square centimeters of graphite paper in a quartz tube, vacuum-sealing the tube, heating the tube in a tube furnace to 650° C. to gasify the red phosphorus; then lowering the temperature to 240-480° C. and continuing the reaction for 2-24 hours to obtain the graphite paper on which the purple phosphorus array is grown; and using light-induced in-situ reduction to controllably coat silver nanoparticles on the surface of the purple phosphorus array to prepare the purple phosphorus array silver composite surface-enhanced Raman scattering substrate. The invention has the advantages of significantly enhancing the Raman signal, being conducive to reducing the detection limit of bacteria, and achieving high-sensitivity detection.

This invention discloses a method for preparing an electrochemical uranium extraction electrode material and an electrochemical uranium extraction apparatus. The preparation method includes: continuously cleaning iron foil in an ultrasonic cleaner using acetone, ethanol, and deionized water, followed by vacuum drying; then annealing the dried iron foil in an alumina crucible in air to generate Fe. 3 O 4 foil; then Fe 3 O 4 Foil soaked in Co(NO) 3 ) 2 ·6H 2 After soaking in solution O, the Fe was dried in a vacuum dryer, and then the dried Fe was... 3 O 4 The foil was annealed in air to complete the first cobalt loading, yielding Co. 3 O 4 @Fe 3 O 4 -1, repeated loading, yielding Co 3 O 4 @Fe 3 O 4 Nanosheet array; this invention is applied to the working electrode of a three-electrode electrochemical workstation for uranium removal. This invention has the following advantages: it can greatly accelerate the capture and reduction of uranium in electrochemical uranium removal, improve the uranium extraction rate, and has excellent uranium extraction capabilities. At the same time, the manufacturing process is simple and the cost is low.

The present invention discloses a method for preparing a vanadium dioxide film, comprising the following steps: Step 1: Substrate cleaning: After the substrate is sequentially cleaned with deionized water, acetone, ethanol, and ultrasonically cleaned with deionized water, a nitrogen gun is used to blow the substrate dry for standby use; Step 2: A first vanadium metal layer is plated on the substrate using a magnetron sputtering method; Step 3: The first vanadium metal layer is oxidized to obtain a vanadium oxide layer; Step 4: A second vanadium metal layer is plated on the vanadium oxide layer using a magnetron sputtering method; Step 5: The substrate plated with the material is subjected to an annealing step. The preparation method of the present invention adjusts the vanadium / oxygen molar ratio in the overall film layer by re-plating a metal vanadium layer of different thicknesses according to the oxidation degree of the metal vanadium. The method has low requirements for film deposition and annealing, and the prepared VO2 film has excellent electrical properties. Before and after the phase change, the change amplitude of the square resistance can reach 4 orders of magnitude.

The invention relates to a method for extracting and separating natural substances, in particular to a method for extracting reserpine from rauvolfia verticillate under the assistance of microwaves, which comprises the following steps: S10, an extraction step: crushing rauvolfia verticillate root bark, mixing with an acidic ethanol solution, and carrying out microwave extraction; s20, coarse crystallization: centrifuging the extracting solution, concentrating, performing acid precipitation, adding methanol for reflux, and standing to obtain a crude product; and S30, recrystallization: pulping the crude product with ethanol, recrystallizing with an acetone-ethanol system, and drying to obtain a finished product. The method disclosed by the invention is environment-friendly and high in extraction efficiency, the time of the extraction process is greatly shortened, and the use amount of a toxic organic solvent is reduced; meanwhile, ethanol is used for replacing an organic solvent in the process, so that the process is simple and convenient, the operation is simple, the toxicity is low, the safety is high, organic solvent recovery is facilitated, and the production cost is reduced.

The invention discloses a flexible Fe / Cu-MOF (at) CC composite film material and a preparation method and application thereof.According to the method, impurities on the surface of a flexible substrate (carbon cloth) are removed through ultrasonic cleaning of acetone, ethyl alcohol and deionized water, then hydrophilic groups are introduced through activation of nitric acid, then FeCl3. 6H2O, CuCl2. 2H2O and 2, 5-dihydroxyterephthalic acid are dissolved in a DMF / methyl alcohol system to form a precursor solution, and the precursor solution is subjected to ultrasonic cleaning and drying to obtain the flexible Fe / Cu-MOF (at) CC composite film material. And performing in-situ growth of the Fe / Cu-MOF film on the activated substrate through a hydrothermal method. According to the technology, a Fe / Cu double-metal synergistic center is introduced, so that an MOF electronic structure is effectively regulated and controlled, the problems of weak interference capability and low dissociation efficiency of a water molecule hydrogen bond network caused by a single metal site and a fixed electronic structure of traditional MOFs are solved, the interface water evaporation performance of the material under a complex working condition is remarkably improved, and the preparation method is suitable for industrial production. The device is suitable for solar-driven seawater desalination and wastewater treatment.

This invention relates to the field of organic synthesis technology, specifically to a synthesis process for S-(+)-4-phenyl-2-oxazolidinone. The synthesis process for S-(+)-4-phenyl-2-oxazolidinone provided by this invention not only enables the recovery and utilization of organic solvents such as tetrahydrofuran and toluene, saving resources and reducing production costs, but also reduces environmental pollution. Furthermore, the S-(+)-4-phenyl-2-oxazolidinone synthesized by this invention has advantages such as high purity and high yield, effectively ensuring the grade and quality of S-(+)-4-phenyl-2-oxazolidinone. It appears as a white or off-white crystalline powder, readily soluble in DMSO, acetone, and ethanol.

The invention relates to the technical field of gas adsorption materials, in particular to MOF-based gas adsorption filter cloth as well as a preparation method and application thereof. The preparation method comprises the following steps: by taking a polypropylene non-woven fabric as a base material, carrying out acetone / ethanol ultrasonic cleaning and amino silanization treatment to construct a pretreatment interface layer containing a-NH2 functional group; the preparation method comprises the following steps: synthesizing a hybrid ligand H3BTA-SO3H with double acidic sites of a sulfonic acid group and a carboxylic acid group by adopting a palladium-catalyzed Suzuki coupling reaction; in-situ coordination of aluminum / zirconium metal salt and a hybrid ligand is realized through a hot press molding process, and an MOF crystal structure and sulfonamide bond (-SO2-NH-) interface chemical bridging is synchronously formed, so that the MOF-based gas adsorption filter cloth is obtained. According to the filter cloth, the interface bonding strength is enhanced through amino silane pretreatment, the adsorption efficiency is synergistically improved through sulfonic acid groups / carboxylic acid groups in the hybrid ligands, efficient adsorption performance is shown on NH3, and efficient removal of low-concentration NH3 can be achieved.

The invention discloses a method for synthesizing phosphino pyridone by using pyridine as a raw material, which is characterized by comprising the following two steps: S1, activating pyridine by using halogenated hydrocarbon as an activating reagent to obtain activated pyridine; an organic solvent used in the activation process is selected from one of acetone, ethanol, methanol, toluene and acetonitrile, the activation reaction temperature is 40-80 DEG C, and the reaction time is 12-24 hours. S2, enabling the activated pyridine to react with an organic phosphine reagent in an alkaline environment to obtain phosphino pyridone; the reaction process is carried out in a mixed solvent of methanol and acetonitrile, the reaction temperature is 60-85 DEG C, and the reaction time is 8-16 hours. The molar ratio of the activated pyridine to the organic phosphine reagent is 1: (2-3). According to the method, the adopted raw material pyridine is low in price and easy to obtain, the reaction yield is relatively good, the atom economy is relatively good, and the method is applicable to mono-substitution or multi-substitution of common alkyl, halogen, alkoxy, aryl, ester groups and the like.

The application discloses a method for extracting antidepression active Euphausia superba oil by adopting subcritical combination solvent, and belongs to the technical field of deep processing of Euphausia superba. The method is a three-stage gradient extraction method of "subcritical butane-acetone-ethanol", and realizes differential separation and enrichment of lipid components by using solvent polarity difference. The first-stage subcritical butane extraction is carried out under low temperature, closed and oxygen isolation conditions, and high-efficiency desolventizing is realized by using reduced pressure gasification, so that the heat-sensitive active ingredients are effectively reserved, and meanwhile, oxidation and metamorphosis of raw materials are avoided, thereby laying a foundation for preparation of subsequent high-quality extracts. The method successfully prepares three Euphausia superba oil products with significant component differences, and especially, the third-stage extract and the enzymatic modification product thereof exhibit excellent antidepression activity. The application realizes functional separation of Euphausia superba lipid components, and provides strong support for development of personalized and diversified antidepression products.

A preparation method for growing a germanium sulfide (GeS2) single-crystal thin film on a SiO2 substrate includes: cleaning a surface of a substrate with acetone, ethanol and deionized water, where the substrate is a Si / SiO2 substrate or a SiO2 glass substrate; photoetching the substrate, spin-coating a photoresist, and performing photoetching and dry etching or wet etching to obtain a groove pattern; depositing a germanium (Ge)-crystal layer in the groove pattern of the substrate to obtain a treated substrate; and putting the treated substrate into a chemical vapor deposition (CVD) device for growth, a growth source being high-purity sulfur (S) powder and high-purity Ge powder, thereby obtaining a GeS2 single-crystal thin film on the SiO2 substrate. The preparation method can grow GeS2 single crystals on the SiO2 substrate. The GeS2 single crystals have a high crystalline quality and a small surface roughness.

The invention relates to the field of friction nano power generation and paper-based functional materials, in particular to an aramid paper-based friction nano power generation material with a sandwich gradient structure and a preparation method of the aramid paper-based friction nano power generation material. According to the material, a paper base obtained by synergistic papermaking of para-aramid fiber and meta-aramid fibrid which are subjected to acetone and ethanol cleaning and H2O2 oxidation modification is taken as a core layer, and polar groups such as hydroxyl and carboxyl are introduced into the surface of the modified fiber, so that the electronegativity and interfacial activity of the paper base are enhanced. And a continuous charge conduction path is formed in the paper base through micro MXene impregnation, so that the charge capture and migration efficiency is improved. The aramid nanofiber membrane which is blade-coated on the outer layer serves as a high-friction functional layer, a higher interface potential difference is formed between rich hydrogen bond sites of the aramid nanofiber membrane and the PTFE negative electrode, and the electron transfer amount can be increased. The obtained modified aramid paper base layer-MXene transport layer-ANF friction layer sandwich structure is light and flexible, large-area processing can be achieved, synergistic enhancement of triboelectrification and charge conduction is achieved on the microscopic level, the output performance is obviously better than that of a traditional paper-based triboelectricity material, and the modified aramid paper base layer-MXene transport layer-ANF friction layer sandwich structure is suitable for application such as flexible wearing, self-powered sensing and micro-nano energy collection.

A use of Verbascum extract on various materials for the treatment of oil-grease, waste oil and petroleum derivatives and to increase the oil retention capacity of the material, is provided. The material is selected from objects of solid natural or synthetic polymers with a porous structure or high surface roughness, granules in bulk forming gaps, gels or cellulosic materials, fabrics, textiles or woven textile materials. The Verbascum extract is obtained with an aid of a homogenizer using a solvent selected from acetone, ethanol, and methanol.

The present invention discloses a SiO2@phosphate glass lubricating additive for titanium alloy profile extrusion and its application. The preparation method of the SiO2@phosphate glass lubricant is to mix modified phosphate glass powder, SiO2 colloidal solution and toluene, and then stir magnetically, and wash the stirred solution with acetone, ethanol and distilled water to obtain the SiO2@phosphate glass lubricating additive. The application of the SiO2@phosphate glass lubricant is to prepare a glass lubricant for titanium alloy profile extrusion. The lubricant for titanium alloy profile extrusion prepared by using the glass lubricating additive of the present invention has excellent and stable lubrication in the temperature range of 800-950°C, and has a low friction coefficient (0.1-0.18), excellent lubrication effect, and can effectively reduce cracks on the surface of the titanium alloy and improve its surface quality.

The preparation method comprises the following steps: step 1, taking a mixed solution of acetone and ethanol as a solvent, adding N, N-dimethyl propane diamine, diethyl ether and perfluorononanoic acid into the mixed solution of acetone and ethanol, after complete reaction, adding chloropropene, continuing reaction, and after the reaction is finished, evaporating to remove the solvent to obtain a polymer oil-displacing agent; the fluorine-carbon cation hydrophobic monomer CF-1 is obtained; step 2, uniformly mixing white oil and an emulsifier Span80 and Tween 80 in a mass ratio of (35-45): (1-3): (1-2) to obtain an oil phase; the preparation method comprises the following steps: dissolving AM, sodium p-styrenesulfonate and a fluorocarbon cation hydrophobic monomer CF-1 in deionized water, adding sodium hydrogen sulfite, and uniformly stirring to obtain an aqueous solution; and adding the aqueous solution into the oil phase to obtain a uniform emulsion, adding ammonium persulfate, and reacting to obtain the high-molecular oil-displacing agent. The oil-displacing agent has high temperature resistance and salt resistance, and the adsorption of carbonate reservoirs to the oil-displacing agent is greatly reduced.

The application provides a SEM sample preparation method for micro-nano sample morphology characterization. In the SEM sample preparation method, at least one of acetone, ethanol and methanol is used as a solvent, the solvent is a low-tension, low-boiling-point, high-vapor-pressure and low-viscosity liquid, the included angle between the conductive substrate and the horizontal plane is 15-45 degrees, the specific solvent such as acetone, ethanol and methanol is used to achieve the effect of rapid evaporation, and the dispersed liquid is added to the surface of the conductive substrate which is placed at an angle of 15-45 degrees, so that the micro-nano sample can be uniformly distributed on the conductive substrate, the coffee ring effect is avoided, and the uniformity and integrity of the surface structure of the micro-nano sample are ensured. This method reduces the aggregation of micro-nano sample particles, improves the surface quality of the micro-nano sample, is suitable for high-resolution morphology observation, and can present clearer and finer micro-nano structures in SEM and AFM characterization, thereby helping to accurately analyze the structural characteristics of the micro-nano sample.

The application discloses a method for synthesizing phosphine pyridone from pyridine as raw material, and is characterized by comprising the following two steps: S1, pyridine is activated by using halogenated alkane as an activating agent to obtain activated pyridine; the organic solvent used in the activation process is selected from one of acetone, ethanol, methanol, toluene and acetonitrile, the activation reaction temperature is 40-80 DEG C, and the reaction time is 12-24 hours; S2, the activated pyridine is reacted with an organic phosphine reagent in an alkaline environment to obtain phosphine pyridone; the reaction process is carried out in a mixed solvent of methanol and acetonitrile, the reaction temperature is 60-85 DEG C, and the reaction time is 8-16 hours; and the molar ratio of the activated pyridine to the organic phosphine reagent is 1:2-3. The method has the advantages of cheap and easily available raw material pyridine, good reaction yield and better atomic economy, and is applicable to common alkyl, halogen, alkoxy, aryl, ester group and the like which are mono-substituted or multi-substituted.

The invention belongs to the technical field of chemical synthesis of medicines, and discloses a novel process for producing an alfacalcidol raw material medicine, which comprises the following steps of: introducing a Lewis acid catalyst in a key addition reaction, obviously shortening the reaction time and inhibiting side reaction; a quenching mode of dilution dropwise adding and real-time pH and temperature monitoring is adopted to replace one-time adding of a quenching agent, so that product decomposition or polymerization caused by too high local concentration is avoided; an acetone-ethanol cosolvent system is combined with a programmed gradient cooling crystallization process, so that the freezing point of the solvent is reduced, and crystals with uniform particle size and good fluidity are obtained; and a microwave-vacuum combined drying technology is adopted, so that the drying efficiency is greatly improved, and the moisture absorption stability of the product is improved. The method has the advantages of high overall efficiency, stable product quality, significantly improved product purity and yield, and suitableness for industrial production.

The invention discloses a copper surface nanocrystallization interface preparation method based on vacuum sputtering, and the method comprises the following specific steps: S1, substrate pretreatment: sequentially carrying out acetone and ethanol ultrasonic cleaning and nitrogen blow-drying on an oxygen-free copper substrate, then placing the oxygen-free copper substrate in a vacuum cavity, and carrying out Ar plasma etching to remove surface oxides and form a nanoscale rough surface; s2, magnetron sputtering deposition is conducted, specifically, a direct-current magnetron sputtering system is adopted, metal nanoparticles are deposited on the surface of the substrate, the sputtering power is 50-250 W, and high-purity Ar serves as working gas; s3, electron beam irradiation: carrying out electron beam treatment on the deposited sample under the conditions that the beam density is 1-5 A / cm, the irradiation time is 5-30 minutes and the acceleration voltage is 5-20 kV; and S4, annealing treatment is conducted in the reducing atmosphere. The porosity is reduced, and the density and uniformity of a sintered body are improved.