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Tablet containing cefixime liposome and preparation method thereof

A cefixime and liposome technology, applied in the field of medicine, can solve the problems of poor solubility, stability and bioavailability, and achieve the effects of improving bioavailability, storage stability and significant improvement

Inactive Publication Date: 2011-02-09
王丽燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] Chinese patents CN101606913A and CN101401810A disclose cefixime dispersible tablets and their preparation methods. The dispersible tablets are all made from cefixime raw materials without any modification. The solubility, stability and biological Utilization is poor

Method used

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  • Tablet containing cefixime liposome and preparation method thereof
  • Tablet containing cefixime liposome and preparation method thereof
  • Tablet containing cefixime liposome and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Example 1: Preparation of Cefixime Liposome

[0074] Name of raw materials

Dose 1 (mg)

Dose 2 (mg)

Dose 3 (mg)

Cefixime

50.00

100.00

200.00

Hydrogenated Soy Lecithin

200.00

400.00

800.00

Hydrogenated Egg Yolk Lecithin

200.00

400.00

800.00

cholesterol

400.00

800.00

1600.00

Polysorbate 80

68.00

136.00

272.00

total

918.00

1836.00

3672.00

[0075] Preparation:

[0076] (A) Dissolve hydrogenated soybean lecithin, hydrogenated egg yolk lecithin, cholesterol and polysorbate 80 in an appropriate amount of absolute ethanol according to the prescription amount, and mix well to obtain solution I; the amount of absolute ethanol used is the amount of cefixime 30 times;

[0077] (B) Weigh the prescribed amount of cefixime and add an appropriate amount of phosphate buffer with a pH of 8.0 to completely dissolve it to obtain a cefixime solution;

[0078] (C) Weigh povidone K according to the prescription amount 30 , Add the above-mentioned phosphate buffer...

Embodiment 2

[0084] Example 2: Preparation of Cefixime Liposome

[0085] Name of raw materials

Dose 1 (mg)

Dose 2 (mg)

Dose 3 (mg)

Cefixime

50.00

50.00

100.00

Hydrogenated Soy Lecithin

162.50

325.00

650.00

Hydrogenated Egg Yolk Lecithin

162.50

325.00

650.00

cholesterol

325.00

650.00

1300.00

Polysorbate 80

27.50

55.00

110.00

total

727.50

1405.00

2810.00

[0086] Preparation:

[0087] (A) Dissolve hydrogenated soybean lecithin, hydrogenated egg yolk lecithin, cholesterol and polysorbate 80 in an appropriate amount of absolute ethanol according to the prescription amount, and mix well to obtain solution I; the amount of absolute ethanol used is the amount of cefixime 25 times;

[0088] (B) Weigh the prescribed amount of cefixime, add an appropriate amount of phosphate buffer with a pH of 7.5 to completely dissolve it to obtain a cefixime solution;

[0089] (C) Weigh povidone K according to the prescription amount 30 , Add the above-mentioned phosphate buffer to d...

Embodiment 3

[0095] Example 3: Preparation of Cefixime Liposome

[0096] Name of raw materials

Dose 1 (mg)

Dose 2 (mg)

Dose 3 (mg)

Cefixime

50.00

100.00

200.00

Hydrogenated Soy Lecithin

140.00

280.00

560.00

Hydrogenated Egg Yolk Lecithin

140.00

280.00

560.00

cholesterol

280.00

560.00

1120.00

Polysorbate 80

47.50

95.00

190.00

total

657.50

1315.00

2630.00

[0097] Preparation:

[0098] (A) Dissolve hydrogenated soybean lecithin, hydrogenated egg yolk lecithin, cholesterol and polysorbate 80 in an appropriate amount of absolute ethanol according to the prescription amount, and mix well to obtain solution I; the amount of absolute ethanol used is the amount of cefixime 35 times;

[0099] (B) Weigh the prescribed amount of cefixime and add an appropriate amount of phosphate buffer with a pH of 7.0 to completely dissolve it to obtain a cefixime solution;

[0100] (C) Weigh povidone K according to the prescription amount 30 , Add the above phosphate buffer to dissolv...

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Abstract

The invention relates to a cefixime liposome and a preparation method thereof as well as a tablet containing the cefixime liposome. The tablet comprises a cefixime liposome and a pharmaceutically acceptable vector, wherein the cefixime liposome comprises the following components in parts by weight: 1 part of cefixime, 1.25-5 parts of hydrogenated soybean lecithin, 1.25-5 parts of hydrogenated yolk lecithin, 1.25-10 parts of cholesterol and 0.1-3 parts of polysorbate 80. The tablet not only meets the requirement on Chinese pharmacopoeia but also has the advantages of more stable storage at normal temperature, more obvious curative effect and obvious improvement of bioavailability compared with the traditional cefixime medicament composition.

Description

Technical field [0001] The invention relates to a cefixime liposome, a preparation method thereof, and a tablet containing the cefixime tablet. The cefixime tablet is more stable in storage at room temperature and more effective than ordinary cefixime pharmaceutical compositions. The advantages of fast speed and significantly improved bioavailability belong to the field of medical technology. Background technique [0002] Acute pelvic inflammatory disease refers to the acute inflammation of female pelvic reproductive organs and surrounding connective tissue, pelvic peritoneum, including metritis, tubal oophoritis, pelvic connective tissue inflammation, and pelvic peritonitis. It can occur in one or several places at the same time. It is a woman One of the common diseases. The development of acute pelvic inflammatory disease can cause diffuse peritonitis, sepsis, septic shock, and severe cases can be life-threatening. Abdominal pain accompanied by fever at the time of onset. If ...

Claims

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Application Information

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IPC IPC(8): A61P15/00A61K9/20A61K31/546A61P31/04A61K47/28
Inventor 王丽燕
Owner 王丽燕
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