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Panaxtriol saponin extract and preparation process thereof

A technology of notoginseng triol group and notoginseng saponin, which is applied in the field of extract notoginseng triol saponin extract of traditional Chinese medicine Panax notoginseng and its preparation field, which can solve the problems of high content of notoginseng triol, notoginseng triol and notoginseng two Eliminate problems such as poor alcohol effect, achieve the effect of high content, good separation effect, and convenient operation

Inactive Publication Date: 2011-02-09
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Notoginseng triol and notoginsengdiol have not been effectively separated, and the content of notoginsengdiol is too high
[0017] Since the separation of notoginsengtriol and notoginsengdiol by the above process is not effective, it is necessary to improve the existing extraction technology so that notoginsengtriol and notoginsengdiol can be effectively separated to prepare a product with a high content of notoginsengtriol extract of

Method used

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  • Panaxtriol saponin extract and preparation process thereof
  • Panaxtriol saponin extract and preparation process thereof
  • Panaxtriol saponin extract and preparation process thereof

Examples

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Effect test

Embodiment 1

[0046] Take 20.0g of Panax notoginseng, crush it into coarse particles, add 3 times the amount of 70% ethanol to soak for 8 hours, put it into a percolation barrel for percolation, collect 30 times the percolation liquid, and the percolation flow rate is 1BV / h; Concentrate under reduced pressure at ℃ to 1.5 times of medicinal material, centrifuge at 4200rpm for 20min, put D101 macroporous adsorption resin on the supernatant, the weight ratio of resin to raw material drug is 1:1, the sample loading flow rate is 0.5BV / h, wash with 4 times column volume , the washing flow rate was 1BV / h, and the washing solution was discarded, and eluted with 8 times column volume of 30% ethanol, and the elution flow rate was 1.5BV / h, and the eluent was collected. Recover the eluate until it has no alcohol smell, put it on D941 resin, the weight ratio of resin to medicinal material is 0.8:1, the flow rate of sample loading is 1BV / h, the column volume is 10 times, the flow rate is 1.5BV / h, wash wit...

Embodiment 2

[0050] Take Panax notoginseng 20.0, crush it into coarse particles, add 4 times the amount of 70% ethanol to soak for 6 hours, put it into a percolation barrel for percolation, collect 20 times the percolation liquid, and the percolation flow rate is 1BV / h; Concentrate under reduced pressure to 1.2 times of medicinal materials, centrifuge at 4000rpm for 20min, put D101 macroporous adsorption resin on the supernatant, the weight ratio of resin to raw material drug is 1:1, the sample loading flow rate is 0.5BV / h, wash with 4 times column volume, The washing flow rate was 1 BV / h, the washing solution was discarded, and 20 times the column volume was eluted with 30% ethanol, and the elution flow rate was 1.5 BV / h, and the eluent was collected. Recover the eluate until it has no alcohol smell, apply D941 resin, the weight ratio of resin to medicinal material is 0.5:1, the flow rate of the sample is 1BV / h, 5 times the column volume, the flow rate is 1.5BV / h, wash with water; collect ...

Embodiment 3

[0055] Take 100.0g of Panax notoginseng, crush it into coarse particles, add 8 times the amount of 70% ethanol to soak for 10 hours, put it into a percolation barrel for percolation, collect 20 times the percolation liquid, and the percolation flow rate is 1BV / h; Concentrate under reduced pressure at ℃ to 1.6 times of medicinal material, centrifuge at 6000rpm for 20min, put D101 macroporous adsorption resin on the supernatant, the weight ratio of resin to raw material drug is 1:1, the sample loading flow rate is 0.5BV / h, wash with 4 times column volume , the washing flow rate is 1BV / h, the washing solution is discarded, and eluted with 10 times column volume of 30% ethanol, the elution flow rate is 1.5BV / h, and the eluent is collected. Recover the eluate until it has no alcohol smell, put it on D941 resin, the weight ratio of resin to medicinal material is 1:1, the flow rate of sample loading is 1BV / h, 8 times the column volume, the flow rate is 1.5BV / h, wash with water; collec...

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Abstract

The invention discloses a panaxtriol saponin extract and a preparation process thereof. An extract Rg1 (C42H72O14) accounts for 40 to 70 percent of a total extract, notoginsenoside R1 (C47H80O18) accounts for 10 to 30 percent of the total extract, and ginsenoside Re (C48H82O18) accounts for 5 to 10 percent of the total extract. The preparation method of the extract comprises the following steps of: percolating raw materials through ethanol, concentrating percolate for centrifuging, processing supernate through macroporous weak polar resin, collecting 30 to 40 percent ethanol eluent, concentrating the ethanol eluent and processing the concentrated ethanol eluent through decolorizing resin to obtain the notoginsenoside triol extract. The extract of the invention is high in purity, good in curative effect and stable in quality, and simultaneously, the preparation method is excellent in separation effect, high in content, simple in process, low in cost and convenient to operate and is suitable for industrial production.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract and a preparation method thereof, in particular to a notoginseng triol saponin extract of the traditional Chinese medicine Panax notoginseng and its preparation. Background technique [0002] Panax notoginseng: Also known as Tianqi, it is a plant of the genus Araliaceae ginseng, and it is the "sacred medicine" for treating heart, cerebrovascular diseases and various blood diseases in traditional Chinese medicine. [0003] "Compendium of Materia Medica" was written by Li Shizhen in the Ming Dynasty in 1578: "The taste is slightly sweet and bitter, resembling the taste of ginseng...so it can cure all blood diseases." [0004] "Compendium of Materia Medica Supplements" was written by Zhao Xuemin in the Qing Dynasty in 1765: "Ginseng is the first in nourishing qi, and Sanqi is the first in nourishing blood. It tastes the same and has the same effect, so it is called ginseng and notoginseng, an...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61P9/00
Inventor 李瑞明张兰兰王玉林万里周水平
Owner TIANJIN TASLY PHARMA CO LTD
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