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Parakeratosis inhibitor, pore shrinking agent or agent for preventing or improving rough skin, and composition for external use on the skin containing the same
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A technology for parakeratosis and rough skin, applied in the direction of cosmetic preparations, skin care preparations, anhydride/acid/halide active ingredients, etc.
Active Publication Date: 2011-02-09
SHISEIDO CO LTD
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However, there are currently no reports indicating that NOS inhibitors or N-amidinoglutamic acid have the effect of inhibiting parakeratosis or improving enlarged pores
Method used
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[0164]Add 50 mL of methanol and 10 mL of 10% methanolic hydrochloric acid solution to 5 g of N-acetyl-L-glutamic acid, and heat to reflux for 1 hour. After air cooling, concentrate to obtain a residue, add 20 mL of 40% methylaminemethanol solution to the residue, and stir at room temperature for 2 hours. The reaction solution was concentrated, dried and solidified, and recrystallized from methanol to obtain 3.8 g of the target product.
[0165] The structure of the obtained target product was confirmed by NMR (JEOL EX-400, solvent DMSO).
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Abstract
Provided are an outstandingly effective parakeratosis inhibitor, pore shrinking agent, or agent for preventing or improving rough skin, which contains as active ingredient a compound which has no problems as regards safety, such as sensory irritation, and a composition for external use on the skin containing such a compound. The aforementioned compound is selected from glutamic acid derivatives of general formula (1) or (2) and salts thereof. (A represents a carbamoyl group, a benzyloxycarbonyl group, a C1-3 alkyl group, an aryl group or an amidino group.) (Z is a C1-4 alkyl group, a C2-4 alkenyl group or the like; Y is OH, a C1-3 alkyloxy group, an aryloxy group or NR3R4; and R1-R4 are H, a C1-3 alkyl group, an aryl group, a C3-7 cycloalkyl group, a C3-7 cycloalkenyl group, a phenyl group, or a benzyl group, or NR1R2 or NR3R4 is a heterocyclic ring).
Description
[0001] related application [0002] This application claims the priority of Japanese Patent Application No. 2008-63352 filed on March 12, 2008 and Japanese Patent Application No. 2008-87497 filed on March 28, 2008, and the contents thereof are incorporated into this application. technical field [0003] The present invention relates to a parakeratosis inhibitor that suppresses parakeratosis caused by sebum; suppresses parakeratosis caused by irritating components in sebum around pores, maintains normal skin around pores, and suppresses enlarged pores with a mortar-shaped structure of pores A shrinking agent; a skin roughness preventing / improving agent for preventing / improving skin roughness caused by unsaturated fatty acids, and a composition for external use on skin having the above effects. Background technique [0004] In recent years, especially young women have been concerned about enlarged pores, and people are looking for skin external preparations that improve such e...
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