Preparation method of calcium phosphate nano medicament-carrying systems
A nano-loaded drug and calcium phosphate technology, which is applied in the fields of prosthesis, medical science, and inorganic non-active ingredients, can solve the problems of using organic reagents, depositing on the surface or in large holes, and obvious burst release phenomenon. The effect of toxic and harmful additives, large drug loading, and simple process
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Embodiment 1
[0039] 2.063g ibuprofen and 0.368g CaCl 2 2H 2 O was dissolved in 65 mL of absolute ethanol, and 7 mL of 1 mol / L NaOH aqueous solution and 3 mL of deionized water were added dropwise under magnetic stirring to form solution A. 0.537g Na 2 HPO 4 12H 2 O was dissolved in 25 mL of deionized water to form solution B. The solution B was poured into the solution A under magnetic stirring, and reacted for 1 minute. At this time, the pH value of the mixed solution was measured to be 6.6. The reaction product was collected by centrifugation, washed with water, dried under vacuum at 60°C and then ground. The product of this embodiment is measured by thermogravimetric analysis to have a drug loading of ibuprofen of about 0.47 gram of ibuprofen / gram of calcium phosphate. The drug release curve of the drug-loaded calcium phosphate in simulated body fluid obtained through detection is as follows: figure 1 As shown, it can be seen from the figure that the release behavior research in ...
Embodiment 2
[0042] 2.063g ibuprofen and 0.368g CaCl 2 2H 2 O was dissolved in 65 mL of absolute ethanol, and 10 mL of deionized water was added dropwise under magnetic stirring to form solution A. 0.537g Na 2 HPO 4 12H 2O was dissolved in 25 mL of deionized water to form solution B. The solution B was poured into the solution A under magnetic stirring, and reacted for 1 minute. At this time, the pH value of the mixed solution was measured to be 3.6. The reaction product was collected by centrifugation, washed with water, dried under vacuum at 60°C and then ground. The product of this example has a drug loading capacity of ibuprofen of about 0.35 grams of ibuprofen / gram of calcium phosphate measured by thermogravimetric analysis, and the release behavior in simulated body fluids shows that the product of this example has a good drug sustained release effect.
Embodiment 3
[0044] 2.063g ibuprofen and 0.368g CaCl 2 2H 2 O was dissolved in 65 mL of absolute ethanol, and 3 mL of 1 mol / L NaOH aqueous solution and 7 mL of deionized water were added dropwise under magnetic stirring to form solution A. 0.537g Na 2 HPO 4 12H 2 O was dissolved in 25 mL of deionized water to form solution B. The solution B was poured into the solution A under magnetic stirring, and reacted for 1 minute. At this time, the pH value of the mixed solution was measured to be 5.6. The reaction product was collected by centrifugation, washed with water, dried under vacuum at 60°C and then ground. The product of this example has a drug loading capacity of ibuprofen of about 0.68 grams of ibuprofen / gram of calcium phosphate as measured by thermogravimetric analysis, and the release behavior in simulated body fluids shows that the product of this example has a good drug sustained release effect.
[0045] The drug-loaded calcium phosphate obtained in Example 3 is subjected to ...
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