Preparation method of 1,2,4-thiadiazole oximido acetic acid compound

A technology for thiadiazoloxime and acetic acid, which is applied in the field of preparation of 1,2,4-thiadiazoloxime acetic acid series compounds, can solve the problem of shortening the operation steps of thiadiazoloxime acetic acid series compounds, many process steps, Complicated operation and other problems, to achieve the effect of unique method and principle, shortened operation steps, and high reaction yield
CN101987837BActive Publication Date: 2013-05-08HEBEI BOLUNTE PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HEBEI BOLUNTE PHARMA
Publication Date
2013-05-08

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Abstract

The invention provides a preparation method of a 1,2,4-thiadiazole oximido acetic acid compound, relating to the technical field of preparation technology of 7-site side chain 1,2,4-thiadiazole oximido acetic acid compound of fourth-generation cephalosporin and fifth-generation cephalosporin. The product is obtained by alkali hydrolysis reaction of the derivative of the 1,2,4-thiadiazole oximido acetic acid compound, and the temperature of the hydrolysis reaction system is controlled to be below 150 DEG C. The method of the invention has peculiar principle, and solves the problems of various technical steps, complex operation and the like in the prior art; in addition, product purification technology and operation technology are simple, the operation steps for manufacturing the thiadiazole oximido acetic acid compound are greatly shortened and reaction yield and product purity are higher. A byproduct which can be detected in a reaction mixture can be lower than 5%, reaction yield can be improved to 75-85%, and purity can be more than 97%. The method of the invention is especially suitable for producing the thiadiazole oximido acetic acid compound products with high purity.
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Description

technical field

[0001] The invention relates to the technical field of preparation technology of the 7-position side chain 1,2,4-thiadiazoxime acetic acid series compounds of the fourth-generation cephalosporin and the fifth-generation cephalosporin. Background technique

[0002] Anti-infective drugs account for 13% of the total share in the medicines used in the world, and cephalosporins, as a class of anti-infective drugs, have always ranked first in the amount of anti-infective drugs. There are many kinds of cephalosporin antibiotics, and they are widely used, and they have already occupied nearly half of the market share of antibiotics. With the continuous update of the structure of cephalosporin compounds and the continuous optimization of drug efficacy, human beings have entered the era of the fourth generation, or even the fifth generation of cephalosporins, and are solving the problem of the use of the first three generations of cephalosporin antibiotics in resisting...

Claims

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