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Compound lincomycin hydrochloride injection and reparation method thereof

A technology for lincomycin hydrochloride and injection, which is used in pharmaceutical formulations, medical preparations containing active ingredients, drug delivery, etc., can solve the problems of limited bactericidal effect, reduce the probability of drug resistance, expand the scope of antibacterial, and improve the curative effect. quick effect

Inactive Publication Date: 2011-03-30
TIANJIN BIJIA PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When the two are used alone, the bactericidal effect is limited

Method used

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  • Compound lincomycin hydrochloride injection and reparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A kind of compound lincomycin hydrochloride injection, every 1000L injection is made of the following raw materials:

[0021] Lincomycin hydrochloride 30kg, kanamycin sulfate 30kg, aminopyrine 50kg, prednisolone acetate 1kg, 95% ethanol 100L, the rest is water for injection.

[0022] A preparation method of compound lincomycin hydrochloride injection, the steps are as follows:

[0023] (1) Put aminopyrine and prednisolone acetate into 95% ethanol, stir for 10-25 minutes until clear;

[0024] (2) Get 300L of water for injection, add kanamycin sulfate and lincomycin hydrochloride successively and stir to dissolve;

[0025] (3) Combine the solutions prepared by "(1)" and "(2)", add water for injection to 1000L, stir evenly, keep for 15-20 minutes, and wait for the liquid to become clear.

Embodiment 2

[0027] A kind of compound lincomycin hydrochloride injection, every 1000L injection is made of the following raw materials:

[0028] Lincomycin hydrochloride 110kg, kanamycin sulfate 110kg, aminopyrine 150kg, prednisolone acetate 20kg, 95% ethanol 400L, the rest is water for injection,

[0029] A preparation method of compound lincomycin hydrochloride injection, the steps are as follows:

[0030] (1) Put aminopyrine and prednisolone acetate into 95% ethanol, stir for 10-25 minutes until clear;

[0031] (2) Get 300L of water for injection, add kanamycin sulfate and lincomycin hydrochloride successively and stir to dissolve;

[0032] (3) Combine the solutions prepared by "(1)" and "(2)", add water for injection to 1000L, stir evenly, keep for 15-20 minutes, and wait for the liquid to become clear.

Embodiment 3

[0034] A kind of compound lincomycin hydrochloride injection, every 1000L injection is made of the following raw materials:

[0035] Lincomycin hydrochloride 90kg, kanamycin sulfate 90kg, aminopyrine 100kg, prednisolone acetate 15kg, 95% ethanol 300L, the rest is water for injection,

[0036] A preparation method of compound lincomycin hydrochloride injection, the steps are as follows:

[0037] (1) Put aminopyrine and prednisolone acetate into 95% ethanol, stir for 10-25 minutes until clear;

[0038] (2) Get 300L of water for injection, add kanamycin sulfate and lincomycin hydrochloride successively and stir to dissolve;

[0039] (3) Combine the solutions prepared by "(1)" and "(2)", add water for injection to 1000L, stir evenly, keep for 15-20 minutes, and wait for the liquid to become clear.

[0040] Clinical Trials:

[0041] 1. Experimental animals:

[0042] Randomly select 100 diseased adult pigs with a body weight of 40-80kg.

[0043] 2. Experimental drug:

[0044] ...

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Abstract

The invention relates to compound lincomycin hydrochloride injection and a preparation method thereof. The preparation method comprises the following steps: (1) adding aminopyrine and prednisolone acetate into 95% ethanol and stirring for 10-25 min until the solution is clear; (2) fetching 300 L of injection water, adding kanamycin sulfate and lincomycin hydrochloride in turn and stirring for dissolution; and (3) mixing the solutions obtained in steps (1) and (2), adding injection water until the solution volume is 1,000 L, uniformly stirring and maintaining for 15-20 min until the liquid medicine is clear to obtain the compound lincomycin hydrochloride injection. The invention has the advantages that the compound preparation of kanamycin sulfate and lincomycin hydrochloride, the aminopyrine with adjuvant therapy effect and prednisolone acetate with adjuvant therapy effect are adopted and combined for use, thus achieving antibacterial action on gram-negative bacteria and gram-positive bacteria due to the joint application of the four medicines; and the antimicrobial spectrum is wide, the antimicrobial range is expanded, pig paratyphus and certain complications can be comprehensively treated, the curative effect is good and quick, the drug resistance rate of bacteria is reduced and the curative effect is enhanced.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to a compound lincomycin hydrochloride injection and a preparation method thereof. Background technique [0002] Porcine paratyphoid fever is a common infectious disease of pigs. It poses a great threat to the pig industry. It is often the focus of prevention and treatment of piglet diarrhea in winter. If it cannot be diagnosed and treated or due to wrong diagnosis, it will often bring great losses to the pig industry. . [0003] Porcine paratyphoid disease is characterized by septicemia and chronic necrotic enteritis. The main pathogenic bacteria of the disease are Salmonella, and the bacteria causing porcine paratyphoid fever mainly include Salmonella choleraesuis and Salmonella typhi suis, both of which are Gram-negative bacteria. It has strong adaptability to dry and other environments, and can survive for several weeks or months in the external environment of pigs. [0004]...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7056A61K31/7036A61K31/4152A61K31/573A61K9/08A61P31/04
Inventor 裴毅聂江力李华声马明娟
Owner TIANJIN BIJIA PHARMA CO LTD
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