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Avian decoquinate oral suspension and preparation method thereof

A technology of oral suspension and decoquinate, which is applied in the direction of liquid delivery, emulsion delivery, drug combination, etc., can solve the problems of reducing the effect of anticoccidial, high cost, easy mixing and unevenness, etc., to solve the toxicity and residual problems, easy to use, and the effect of overcoming high cost

Inactive Publication Date: 2011-04-13
QILU ANIMAL HEALTH PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Since the 1970s, decoquinate has been widely used in the prevention and treatment of poultry coccidiosis in many countries, but it has not been used in China
From a clinical point of view, the premix is ​​inconvenient to use and is prone to uneven mixing, thereby affecting drug absorption and reducing the effect of anticoccidia; the solution is prepared from an organic solvent, has low content, high production cost, and organic Solvents are not easy to metabolize, produce residues, and are prone to irritation and toxicity
Chinese patent application CN101564376 (Application No. 200910020452.5) ​​and CN101590055 (Application No. 200910065385.9) disclose decoquinate preparations are prepared by a solid dispersion method, adding a large amount of polymer materials, expensive, complicated process, and residual organic solvents

Method used

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  • Avian decoquinate oral suspension and preparation method thereof
  • Avian decoquinate oral suspension and preparation method thereof
  • Avian decoquinate oral suspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A kind of decoquinate oral suspension for poultry, every 100 milliliters contains the following components:

[0029] Decoxyquinate 6g

[0030] Xanthan gum 0.5g

[0031] Polysorbate 80 2g

[0032] Benzyl alcohol 0.5g

[0033] Add purified water to 100ml

[0034] Preparation method and steps:

[0035] Take by weighing 6g decoquinate, add 2g polysorbate 80, 0.5g xanthan gum and 30ml purified water, stir evenly, then add the remaining amount of purified water, mix uniformly, and homogenize through a high-pressure homogenizer to obtain 6 % decoquinate oral suspension.

Embodiment 2

[0037] Decoxyquinate oral suspension for poultry as described in embodiment 1, the difference is:

[0038] Decoxyquinate 6g

[0039] Xanthan gum 0.5g

[0040] Sodium Lauryl Sulfate 3g

[0041] Sodium Benzoate 0.5g

[0042] Add purified water to 100ml

[0043] The preparation method and steps are the same as in Example 1.

Embodiment 3

[0045] Decoxyquinate oral suspension for poultry as described in embodiment 1, the difference is:

[0046] Decoxyquinate 6g

[0047] Polyvinylpyrrolidone K17 1g

[0048] Sodium Carboxymethyl Cellulose 1g

[0049] Polysorbate 80 2.5g

[0050] Benzyl alcohol 0.5

[0051] Add purified water to 100ml

[0052] The preparation method and steps are the same as in Example 1.

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Abstract

The invention relates to an avian decoquinate oral suspension and a preparation method thereof, belonging to the technical field of veterinary drug preparations. The avian decoquinate oral suspension comprises the following components per 100ml: 5-15g of decoquinate, 0.5-10g of surfactant, 0.1-2g of binding agent, 0.1-2g of stabilizer and 100ml of volume-metered solvent. The avian decoquinate oral suspension overcomes the defects of nonuniform stirring of premixed preparation and insufficient absorption, and can be clinically used only by dilution so that the use method is simple and convenient; and in addition, the organic solvent of the avian decoquinate oral suspension is low in content, the cost of unit preparation is effectively reduced, and the problems of high preparation cost and difficult popularization and application of the traditional preparation are solved.

Description

technical field [0001] The invention relates to a decoquinate oral suspension for poultry and a preparation method thereof, belonging to the technical field of veterinary drug preparations. Background technique [0002] Coccidiosis is an important disease of the poultry industry worldwide and is caused by various parasites of the genus Eimeria, including Eimeria acuminata, Eimeria brucei, Eimeria maxima, tender Eimeria, poisonous Eimeria and mutant Eimeria, etc. These parasites multiply in the intestinal epithelial cells, destroy the integrity of the intestinal mucosa, and reduce the digestion and absorption capacity of the intestine. Coccidiosis kills 6%-10% of poultry every year, and coccidiosis can lead to reduction in growth rate and feed conversion rate of poultry, resulting in global economic losses reaching billions of dollars every year. At present, the prevention and treatment of coccidiosis is mainly based on drugs, and chemical drugs are still the main means of ...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/47A61P33/02
Inventor 李成应王海挺吴连勇田玉柱
Owner QILU ANIMAL HEALTH PROD
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