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BCL-2 protein expressor, apoptosis inhibitor and preventive for UV-DNA damage in epidermal cells

A technology of BCL-2 and apoptosis inhibitor, which is applied in skin care preparations, skin diseases, cosmetic preparations, etc., can solve problems such as hair whitening and defect, and achieve the effect of improving health and cell tissue repair

Inactive Publication Date: 2011-04-27
NISHIHARA CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] In addition, the BCL-2 gene is known to be a gene necessary for the maintenance of pigment stem cells, and its deficiency causes hair graying

Method used

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  • BCL-2 protein expressor, apoptosis inhibitor and preventive for UV-DNA damage in epidermal cells
  • BCL-2 protein expressor, apoptosis inhibitor and preventive for UV-DNA damage in epidermal cells
  • BCL-2 protein expressor, apoptosis inhibitor and preventive for UV-DNA damage in epidermal cells

Examples

Experimental program
Comparison scheme
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Embodiment

[0051] [Manufacturing method of actual production of licorice extract (T)]

[0052] 1) [Add 2000 liters (hereinafter, expressed as liters in L) of water to 200 kg of northeast licorice silk, extract at 95° C. for 2.5 hours, and filter the extract with a vibrating sieve (300 mesh, made of stainless steel). The obtained extract filtrate was concentrated (liquid temperature 60° C. or lower, reduced pressure), and the concentrated solution was spray-dried (spray-dried stock solution) to obtain a dry extract. The extract was sieved (60 mesh, made of stainless steel) to obtain a dry extract of licorice (T original) with a yield of 20 kg.

[0053] 2) Add 100 L of Pharmacopoeia ethanol to 20 kg of Northeast Glycyrrhizae dry extract (T original) obtained in 1), stir for 6 hours, and filter with No. 2 filter paper.

[0054] 3) Add pharmacopoeia ethanol to the filtrate so that the final volume reaches 100 L, add 4.5 kg of activated carbon (granular Egret KL), stir for 3 hours, and filte...

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Abstract

It is intended to provide an apoptosis inhibitor, which inhibits apoptosis of cells having DNA directly or indirectly damaged by UV light or the like, can be added to any of various drug agents by increasing cellular tissue repair and can be expected to have a wide application. The apoptosis inhibitor is an apoptosis inhibitor for epidermal cells and the like containing a licorice extract solublein water and ethanol as an active ingredient. The apoptosis inhibitor has an anti-apoptotic factor due to the expression of BCL-2 protein, and has a preventive effect on DNA damage by UV light. It reduces DNA damage by exposure to UV light in epidermal cells and does not abnormally or adversely affect normal skin cells.

Description

technical field [0001] The present invention relates to a BCL-2 protein expression agent in cells such as skin, a cell apoptosis inhibitor and an ultraviolet DNA damage prevention agent for epidermal cells. Background technique [0002] Licorice root is a well-known crude drug, which is used as a medicinal or sweetener raw material, and is also used as a component of external skin preparations such as cosmetics. Furthermore, it is known that the extract of licorice leaves extracted with water or an aqueous solvent such as an alcohol solution has an action of promoting collagen production in fibroblasts of the skin. [0003] Through this action, the licorice extract promotes the production of fibrous collagen in the dermis, maintains skin tension, and maintains a moisture retention mechanism through the collagen, thereby preventing aging of the skin (Patent Document 1). [0004] In addition, it is also known that licorice extract suppresses the formation of melanin in the sk...

Claims

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Application Information

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IPC IPC(8): A61K36/48A61K8/97A61Q19/06
CPCA61Q19/004A61K8/97A61K8/34A61K8/9789A61P17/00
Inventor 田北雅夫
Owner NISHIHARA CO
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