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Pediatric anesthesia induction oral administration formulation and preparation method thereof

A technology of anesthesia induction and dosage forms, applied in the field of medicine, can solve the problems of increased incidence of complications, poor acceptance in children, increased regurgitation and aspiration, etc., and achieve a low probability of regurgitation and aspiration, good satisfaction, and firm attachment Effect

Inactive Publication Date: 2011-06-01
陈明华 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the country is relatively backward, and the main anesthesia induction scheme for children is intramuscular injection or intravenous injection of sedative drugs. Acupuncture will cause psychological harm to awake children and increase the incidence of postoperative complications.
Oral anesthesia induction dosage forms for children at home and abroad mainly include preparations of various types of syrup mixed with sedatives. The administration method is to achieve the purpose of sedation after oral solid or liquid sedative drugs mixed with a certain amount of water. Poor, drinking water before induction of anesthesia may increase the risk of reflux and aspiration

Method used

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  • Pediatric anesthesia induction oral administration formulation and preparation method thereof
  • Pediatric anesthesia induction oral administration formulation and preparation method thereof
  • Pediatric anesthesia induction oral administration formulation and preparation method thereof

Examples

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Effect test

Embodiment 1

[0030] Step 1. Mix sucrose and maltose at a mass ratio of 1:1, heat and stir under normal pressure for about ten minutes to obtain a homogeneous and transparent sugar solution; the temperature of the sugar solution is controlled at about 180°C;

[0031] Step 2, select midazolam as the bulk drug, determine the amount of midazolam added according to the sedative dose, add the bulk drug midazolam to the sugar solution described in step 1, stir until the bulk drug is fully dissolved and mix evenly, to obtain a liquid sedative;

[0032] Step 3: Place the spherical plastic core 1 of the plastic core in the liquid sedative and rotate it so that the gap between the ridge-like protrusion stripes 1-2 of the spherical plastic core 1 is filled with liquid sedative, take it out after the sedative completely covers the ridge-like protrusion stripes, and continue Rotate until it is naturally cooled and formed to obtain a dosage form for pediatric anesthesia induction. The weight of the solid ...

Embodiment 2

[0042] Step 1. Mix sucrose and maltose at a mass ratio of 1:1, heat and stir under normal pressure for about ten minutes to obtain a homogeneous and transparent sugar solution; the temperature of the sugar solution is controlled at about 180°C;

[0043] Step 2, select dexmedetomidine as the bulk drug, determine the amount of dexmedetomidine added according to the sedative dose, add the bulk drug dexmedetomidine to the sugar solution described in step 1, and stir until the bulk drug is fully dissolved and mix evenly to obtain a liquid sedative;

[0044] Step 3: Place the spherical plastic core 1 of the plastic core in the liquid sedative and rotate it so that the gap between the ridge-like protrusion stripes 1-2 of the spherical plastic core 1 is filled with liquid sedative, take it out after the sedative completely covers the ridge-like protrusion stripes, and continue Rotating to natural cooling and molding to obtain a pediatric anesthesia induction buccal dosage form, the we...

Embodiment 3

[0054] Step 1. Mix sucrose and maltose at a mass ratio of 1:1, heat and stir under normal pressure for about ten minutes to obtain a homogeneous and transparent sugar solution; the temperature of the sugar solution is controlled at about 180°C;

[0055] Step 2. Select ketamine as the raw material drug, determine the amount of ketamine added according to the sedative dose, add the raw drug ketamine into the sugar solution described in step 1, stir until the raw material drug is fully dissolved and mix evenly to obtain a liquid sedative;

[0056] Step 3: Place the spherical plastic core 1 of the plastic core in the liquid sedative and rotate it so that the gap between the ridge-like protrusion stripes 1-2 of the spherical plastic core 1 is filled with liquid sedative, take it out after the sedative completely covers the ridge-like protrusion stripes, and continue Rotate until it is naturally cooled and molded to obtain a pediatric anesthesia induction buccal dosage form. The weight...

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Abstract

The invention provides a pediatric anesthesia induction oral administration formulation and a preparation method thereof. The formulation consists of a solid sedative and a plastic inner core, wherein the solid sedative consists of cane sugar, maltose and raw material medicaments; the plastic inner core consists of a spherical plastic core and a plastic rod; the solid sedative is coated on the surface of the spherical plastic core; and the spherical plastic core consists of a spherical inner core and ridge-shaped convex strips which are symmetrically and longitudinally distributed on the surface of the spherical inner core. The preparation method comprises the following steps of: mixing the cane sugar and the maltose; heating under normal pressure and stirring to obtain syrup; adding the raw material medicaments into the syrup according to the amount of the sedative; stirring until the raw material medicaments are fully dissolved to obtain a liquid sedative; and uniformly coating the liquid sedative onto the surface of the spherical plastic core and naturally cooling for molding to obtain the pediatric anesthesia induction oral administration formulation. The pediatric anesthesia induction oral administration formulation is in the lollipop form, is easily accepted by children, makes induction convenient and practicable and avoids the undesirable psychological effects of intramuscular injection and intravenous injection on the children.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a dosage form for children's anesthesia induction and a preparation method thereof. Background technique [0002] At present, the mainstream method of anesthesia induction in children in the world is inhalation induction of gas anesthesia. When inhalation induction cannot be implemented, children must take some sedatives orally before entering the operating room for routine anesthesia induction. However, the country is relatively backward, and the main anesthesia induction scheme for children is intramuscular injection or intravenous injection of sedative drugs. Acupuncture will cause psychological harm to awake children and increase the incidence of various postoperative complications. Oral anesthesia induction dosage forms for children at home and abroad mainly include preparations of various types of syrup mixed with sedatives. The administration method is to achi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/135A61K31/4174A61K31/485A61K31/5513A61K31/5517A61K47/26A61P23/00A61P25/20
Inventor 陈明华张西京
Owner 陈明华
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