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In vivo absorbable metal intervertebral fusion cage

A technology of intervertebral fusion device and fusion device, applied in the direction of internal fixator, internal bone synthesis, prosthesis, etc., to achieve the effect of relieving pain, maintaining support height, and realizing intervertebral bone healing

Inactive Publication Date: 2011-06-08
SUZHOU ORIGIN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

About the absorbable intervertebral fusion cage made of absorbable magnesium alloy, there is no report at home and abroad

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  • In vivo absorbable metal intervertebral fusion cage
  • In vivo absorbable metal intervertebral fusion cage
  • In vivo absorbable metal intervertebral fusion cage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The in vivo absorbable metal intervertebral fusion cage is made of pure magnesium with a purity of 99.9%. The size of the fusion cage prepared in this example is 8mm×5mm, the wall thickness is 1mm, and the height is 7mm. The angle between the upper side of the fusion cage and the horizontal angle is 8°( figure 1 ), adapted to the natural curvature of the sheep cervical spine, two fusion devices are required to be placed into the posterior edge of the distracted vertebral body, and applied to larger defects. figure 2 About three months after implantation in the cervical spine of the sheep, the sheep was sacrificed, and the implantation site was taken out. The exact place of implantation is shown in the box. It can be seen from the macroscopic state that the tissue around the implantation site has healed well. The organization is the same. It shows that the biocompatibility of the pure magnesium intervertebral fusion device is good after implantation.

Embodiment 2

[0033] The body absorbable metal intervertebral fusion device is made of Mg-Zn alloy, the mass content of magnesium is 10%-100%, and the total content of Zn element is 0-90%. The size of the fusion vessel prepared in this example is 14mm×13mm, the wall thickness is 2mm, and the height is 8mm. The preparation method is as follows: the Mg-Zn square with rounded corners is cut out by wire cutting, and the method of mechanically engraving with CNC machine tools Carve out the clamping teeth, and then use the wire cutting method to cut out two hollow parts and clamping holes, so as to avoid internal small cracks caused by thin-walled clamping. When using it, two fusion devices are used, placed into the posterior edge of the distracted vertebral body, and applied to larger defects. image 3 Degradation on the day of implantation (left) and one month after implantation (right) in the sheep cervical spine. On the day of implantation, the bone defect indicated by the arrow has been rep...

Embodiment 3

[0035] The absorbable metal intervertebral fusion cage in the body is made of Mg-Zn alloy, and the Zn content can be selected to be between 4-6±0.5%. After soaking in normal saline to lose weight, the change of three-point bending strength is tested, and the result is obtained. out Figure 4 is the curve of the three-point bending load decreasing with the weight loss rate. It proves that the mechanical properties of the magnesium alloy intervertebral fusion cage will be lost during the degradation process, and it needs to be adjusted by changing the alloy composition, tissue structure, coating, etc. to ensure the maintenance of the support height during the degradation process.

[0036] Using extruded Mg-Zn alloy, the size of the prepared cage is 14mm×13mm, the wall thickness is 2mm, and the height is 8mm. Engraving method carves out the locking teeth, and then cuts out a total of 2 hollow parts and clamping holes by wire cutting, and a total of 4 side wall openings, so as to...

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Abstract

The invention discloses an in vivo absorbable metal intervertebral fusion cage, the fusion cage is made of high-purity magnesium or magnesium alloy, the purity of the high-purity magnesium is not less than 99.9%, the content of the magnesium in the magnesium alloy by weight is 10%-100%, the total content of an alloy element is 0-90%, and the content of other impurity ingredients is not more than 5%; and the alloy element comprises one or more of Zn, Ca, Mn, Fe, Al and rare earth. The in vivo absorbable metal intervertebral fusion cage can be gradually degraded and absorbed in vivo, and the elastic modulus is similar to that of bones, thereby making up for disadvantages that the fusion cage is sunk due to stress shielding effect of titanium alloy material and the like, and the loss of intervertebral support height is caused. Compared with a permanently implanted PEEK (polyetheretherketone) fusion cage, the in vivo absorbable metal intervertebral fusion cage can promote bone repair and enable bone absorption and formation of new bones to be in good matching during the in vivo degradation process; simultaneously, the support height is maintained, the intervertebral bone union can be realized without leaving foreign bodies, the second taking-out can be avoided, and the suffering of a patient can be greatly reduced.

Description

technical field [0001] The invention relates to a fusion device in the field of medical technology, in particular to an absorbable metal type intervertebral fusion device used for bone support (maintaining the height and stability of the vertebrae). Background technique [0002] Intervertebral fusion has been used as a treatment method for spinal diseases and trauma for decades. It refers to resecting the intervertebral disc structure in the intervertebral space, scraping off the upper and lower cartilage endplates, and adding fusion in front of the gravity line between the two vertebral bodies. The container holds various fusion materials. Since intervertebral fusion reconstructs the anterior and middle columns of the spine, it greatly improves the therapeutic effect of spinal degenerative diseases and trauma, making it widely used in a short period of time. The biggest feature of the intervertebral fusion is the effect of support. The earliest intervertebral fusion was ma...

Claims

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Application Information

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IPC IPC(8): A61L27/30A61L27/34A61L27/04A61L31/02A61L31/08A61L31/10A61F2/44A61B17/70
CPCA61F2/44A61F2002/30001
Inventor 李佳楠张小农
Owner SUZHOU ORIGIN MEDICAL TECH
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