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An extract for preventing and treating angina pectoris of coronary heart disease, their preparation method and application

The technology of extract and preparation is applied in the field of extraction of compound salvia miltiorrhiza preparations for cardiovascular medicine, which can solve the problems of refining, the content of active ingredients needs to be improved, and the lack of means for quality control.

Active Publication Date: 2016-11-23
TIANJIN TASLY MORDEN TCM RESOURCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] In the prior art, there is no step of monitoring and refining the active ingredients of the extract, so that the existing compound salvia miltiorrhiza preparations lack quality control means, and the content of active ingredients still needs to be improved

Method used

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  • An extract for preventing and treating angina pectoris of coronary heart disease, their preparation method and application
  • An extract for preventing and treating angina pectoris of coronary heart disease, their preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0104] Formula: Salvia miltiorrhiza 82.87%, Panax notoginseng 16.21%, Borneol 0.92%.

[0105] Preparation:

[0106] Step 1: Boil Danshen and Panax notoginseng with 8 times the weight of water to extract twice, the first time is 2 hours, the second time is 1 hour, and the extracts are mixed.

[0107] In step 2, the extract is concentrated to 1 times the volume of the medicinal material, applied to the macroporous adsorption resin D301, washed with 1BV of purified water, and eluted with 2.5BV of 80% ethanol, and the 80% alcohol eluate is collected, concentrated or dried.

[0108] Step 3, the extract and borneol are used as the active ingredient of the medicine, the matrix is ​​a eutectic mixture of xylitol and starch, and the feeding ratio is: extract medicine: matrix=1:5.5, add borneol, liquid paraffin is the condensing agent, and the medicine The temperature is 90° C., the materialization time is 1.5 hours, the condensate temperature is 1° C., the drop distance is 7 cm, and t...

Embodiment 2

[0110] Recipe: Salvia 20%, Panax notoginseng 79%, Borneol 1%.

[0111] Step 1: Extracting Danshen and Panax notoginseng with 2 times the weight of water, the number of extractions is 2 times, each extraction is 1 hour, and the extracts are mixed.

[0112] In step 2, the extract is concentrated to 1 times the amount of the medicinal material, applied to the macroporous adsorption resin D301, washed with 1BV of purified water, and eluted with 2.5BV of 60% ethanol, and the 60% alcohol eluate is collected, concentrated or dried.

[0113] Step 3, use step 2 extract and borneol together as pharmaceutical active ingredient, substrate is eutectic mixture of xylitol and starch, feed ratio is: extract medicine: substrate=1: 3, add borneol, liquid paraffin is condensing agent , the drug temperature is 85°C, the material time is 1 hour, the condensate temperature is -2°C, the drop distance is 5cm, and the drop rate is 30 drops per minute.

Embodiment 3

[0115] Formula: Salvia 97%, Panax notoginseng 2%, Borneol 1.0%.

[0116] In step 1, the salvia miltiorrhiza and notoginseng are extracted with 12 times the weight of water, the number of extractions is 2 times, each extraction is 1 hour, and the extracts are mixed.

[0117] In step 2, the extract is concentrated to 1 times the amount of the medicinal material, applied to the macroporous adsorption resin D301, washed with 1BV of purified water, and eluted with 2.5BV of 70% ethanol, and the 70% alcohol eluate is collected, concentrated or dried.

[0118] Step 3, use step 2 extract and borneol together as the active ingredient of the medicine, the substrate is a eutectic mixture of xylitol and starch, and the feeding ratio is: extract medicine: substrate=1:7, add borneol, and liquid paraffin is the condensing agent , the drug temperature is 95°C, the time of chemical change is 2 hours, the temperature of the condensate is 4°C, the drop distance is 10cm, and the drop speed is 45 d...

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Abstract

The invention relates to an extract for preventing and treating angina pectoris of coronary heart disease, their preparation method and application. The preparation method of the present invention comprises the following steps: step 1, extracting Danshen and Panax notoginseng medicinal materials to obtain an extract; step 2, separating the extract with a macroporous resin to obtain an extract; step 3, using the above extract together with borneol as a medicinal active Ingredients, prepared into pharmaceutical preparations.

Description

Technical field: [0001] The invention relates to an extraction method of compound salvia miltiorrhiza preparation for cardiovascular drugs, in particular to a refining method of the extract. Background technique: [0002] Compound Danshen preparation is composed of Danshen, Panax notoginseng, borneol, etc. It has the effects of promoting blood circulation, removing blood stasis, regulating qi and relieving pain. Compound Danshen preparation has been used for a long time in clinical diseases with microcirculation disorders. It has a remarkable curative effect in the treatment of systemic diseases, digestive system diseases, renal system diseases, etc. Therefore, it is more and more widely used. In recent years, in addition to medical system diseases, it is also widely used in dermatology. [0003] The main aspects of the therapeutic effect of the compound Danshen preparation are: coronary heart disease, angina pectoris and microcirculation The nail fold microcirculation in ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61K9/20A61K9/00A61P9/10A61P9/00A61K31/045
Inventor 刘岩丛德刚刘顺航徐波戚可人陈红赵国辉
Owner TIANJIN TASLY MORDEN TCM RESOURCES
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