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Orally disintegrating tablet with rivastigmine tartrate

A technology for rivastigmine tartrate and oral disintegrating tablets, which is applied in the directions of drug combination, nervous system diseases, ester active ingredients, etc., can solve the problems of difficulty in taking medicine, inconvenient use, etc., and achieves good taste, convenient taking and compatibility. good effect

Inactive Publication Date: 2012-06-27
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, many AD patients have difficulty taking medicine, so ordinary capsules are very inconvenient for patients who have difficulty taking medicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The orally disintegrating tablet of rivastigmine tartrate comprises main ingredients and auxiliary materials, and is characterized in that it is formulated according to the following weight percentages: 0.6% of main ingredients and 99.4% of auxiliary materials.

[0033] Rivastigmine tartrate 1.5g (0.6%)

[0034] Microcrystalline Cellulose 55g (22%)

[0035] Mannitol 123.5g (49.4%)

[0036] Lactose 52g (20.8%)

[0037] Anhydrous citric acid 1.5g (0.6%)

[0038] Cross-linked polyvinylpyrrolidone 7.5g (3%)

[0039] Cyclamate 3g (1.2%)

[0040] Menthol 2.5g (1%)

[0041] Micronized silica gel 2.5g(1%)

[0042] Magnesium Stearate 1g (0.4%)

[0043] A total of 1000 tablets were produced

[0044] Among them, lactose and mannitol are fillers, microcrystalline cellulose and cross-linked polyvinylpyrrolidone are disintegrants, anhydrous citric acid, cyclamate and menthol are flavoring agents, magnesium stearate is lubricant, and micronized silica gel is Glidant.

[0045...

Embodiment 2

[0054] The orally disintegrating tablet of rivastigmine tartrate comprises main ingredients and auxiliary materials, and is characterized in that it is formulated according to the following weight percentages: 0.12% of main ingredients and 99.88% of auxiliary materials.

[0055] Rivastigmine Tartrate 3.0g(0.12%)

[0056] Microcrystalline Cellulose 37g (14.8%)

[0057] Mannitol 150g (60%)

[0058] Lactose 40g (16%)

[0059] Anhydrous citric acid 1.5g (0.6%)

[0060] Cross-linked polyvinylpyrrolidone 10g (4%)

[0061] Cyclamate 2g (0.8%)

[0062] Menthol 2g (0.8%)

[0063]Micropowder silica gel 3g(1.2%)

[0064] Magnesium Stearate 1.5 (0.6%)

[0065] A total of 1000 tablets were produced

[0066] The preparation method of the rivastigmine tartrate orally disintegrating tablet of the present invention is the same as in Example 1, and the rivastigmine tartrate orally disintegrating tablet with a tablet weight of 250 mg is obtained.

[0067] test results:

[0068] Tablet ...

Embodiment 3

[0072] The orally disintegrating tablet of rivastigmine tartrate comprises main ingredients and auxiliary materials, and is characterized in that it is formulated according to the following weight percentages: 1.6% of main ingredients and 98.4% of auxiliary materials.

[0073] Rivastigmine tartrate 4g (1.6%)

[0074] Microcrystalline Cellulose 70g (28%)

[0075] Mannitol 92.75g (37.1%)

[0076] Lactose 60g (24%)

[0077] Anhydrous citric acid 2g (0.8%)

[0078] Cross-linked polyvinylpyrrolidone 12.5g (5%)

[0079] Cyclamate 2.5g(1%)

[0080] Menthol 0.25g (0.1%)

[0081] Micronized silica gel 4g(1.6%)

[0082] Magnesium Stearate 2g (0.8%)

[0083] A total of 1000 tablets were produced

[0084] The preparation method of the rivastigmine tartrate orally disintegrating tablet of the present invention is the same as in Example 1, and the rivastigmine tartrate orally disintegrating tablet with a tablet weight of 250 mg is obtained.

[0085] test results:

[0086] Tablet h...

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Abstract

The invention discloses an orally disintegrating tablet with rivastigmine tartrate. The orally disintegrating tablet comprises a main drug of rivastigmine tartrate and supplementary materials of microcrystalline cellulose, mannitol, lactose, crosslinked polyvinylpyrrolidone, sodium cyclamate, menthol, silica gel micropowder and magnesium stearate. The orally disintegrating tablet with the rivastigmine tartrate can be used for effectively treating Alzheimer's disease, is conveniently taken and quickly disintegrated, has a favorable mouth feel and high bioavailability and provides convenience for Alzheimer's disease patients who take medicine inconveniently.

Description

1. Technical field [0001] The invention relates to an oral pharmaceutical preparation for treating Alzheimer's disease and a preparation method thereof, in particular to an orally disintegrating tablet of rivastigmine tartrate which can disintegrate rapidly, release and taste good. 2. Background technology [0002] Rivastigmine tartrate is an acetylcholinesterase inhibitor that selectively acts on the brain and is used for the treatment of moderate to mild Alzheimer's disease (AD). It is the first-line drug for the treatment of AD. [0003] The trend of aging has increased the number of patients with senile dementia, and my country will enter an aging society. At the same time, it is accompanied by a problem that cannot be ignored-the incidence of AD is increasing year by year. The survey found that the average age of AD in northern my country is 75 or 76 years old, and the rate of AD among people over 65 years old is over 15%. The ability of daily life of AD patients decli...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/27A61K47/38A61P25/28
Inventor 张媛媛刘均洪王繁业吴汝林
Owner QINGDAO UNIV OF SCI & TECH