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Costustoot extractive with blood sugar reduction activity and application thereof

A technology for lowering blood sugar and extracts, which is applied in the field of extraction and purification of active parts of traditional Chinese medicine, can solve the problems of ineffective control of complications, gastrointestinal reactions, liver and kidney damage, etc., and achieve good development and application prospects, convenient administration, and high safety. Effect

Inactive Publication Date: 2011-07-27
SOUTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Western medicine is effective in treating diabetes, but there are certain side effects such as gastrointestinal reactions and liver and kidney damage, and the complications cannot be effectively controlled

Method used

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  • Costustoot extractive with blood sugar reduction activity and application thereof
  • Costustoot extractive with blood sugar reduction activity and application thereof
  • Costustoot extractive with blood sugar reduction activity and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1, the preparation of woody extract

[0018] a. Take 300g of dry woody incense, grind it through a 40 mesh sieve, and extract the coarse powder with a volume fraction of 70% industrial ethanol under reflux for 3 times, adding 2100mL of industrial ethanol with a volume fraction of 70% to extract for 30 minutes, and combine 3 The second extract was concentrated under reduced pressure to the extract to obtain 90.5 g of extract I;

[0019] b. Add 100 mL of water to the extract obtained in step a to disperse, extract 3 times with petroleum ether, add 100 mL of petroleum ether each time, collect the petroleum ether extract and water phase respectively, and concentrate the petroleum ether extract to the extract under reduced pressure to obtain Extract II 7.4g;

[0020] c. Extract the aqueous phase collected in step b with ethyl acetate for 3 times, add 100 mL of ethyl acetate each time, combine the ethyl acetate extracts, concentrate under reduced pressure to the e...

Embodiment 2

[0021] Embodiment 2, the preparation of woody extract

[0022] a. Take 300g of dry woody incense, grind it through a 40 mesh sieve, and extract the obtained coarse powder with 75% industrial ethanol by reflux for 3 times, add 2800mL industrial ethanol with a volume fraction of 75% for 30 minutes, and combine for 30 minutes. The second extract was concentrated under reduced pressure to an extract, and 90.7 g of extract I was obtained;

[0023] b. Add 200 mL of water to the extract obtained in step a to disperse, extract 3 times with petroleum ether, add 200 mL of petroleum ether each time, collect the petroleum ether extract and water phase respectively, and concentrate the petroleum ether extract to the extract under reduced pressure to obtain Extract II 7.2g;

[0024] c. Extract the aqueous phase collected in step b with ethyl acetate for 3 times, add 200 mL of ethyl acetate each time, combine the ethyl acetate extracts, concentrate under reduced pressure to the extract, and...

Embodiment 3

[0025] Embodiment 3, the preparation of woody extract

[0026] a, get dry woody 300g, pulverize through 40 mesh sieves, the obtained coarse powder is 85% industrial ethanol reflux extraction 3 times, add the industrial ethanol 3000mL extraction 30 minutes that volume fraction is 85% each time, merge 3 The second extract was concentrated under reduced pressure to an extract, and 90.7 g of extract I was obtained;

[0027] b. Add 300 mL of water to the extract obtained in step a to disperse, extract 3 times with petroleum ether, add 500 mL of petroleum ether each time, collect the petroleum ether extract and water phase respectively, and concentrate the petroleum ether extract to the extract under reduced pressure to obtain Extract II 7.7g;

[0028] c. Extract the aqueous phase collected in step b with ethyl acetate for 3 times, add 500 mL of ethyl acetate each time, combine the ethyl acetate extracts, concentrate under reduced pressure to the extract, and obtain 7.5 g of extrac...

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Abstract

The invention belongs to the technical field of active site extraction and purification of traditional Chinese medicines, and relates to a costustoot extractive with a blood sugar reduction activity, which can be prepared by adopting a method comprising the following steps of: reflowing and extracting costustoot by using 70%-85% by volume fraction of alcohol, merging extracting solutions, and concentrating to an extract at a reduced pressure; and then adding water for dispersion, continuously extracting by using petroleum ether and ethyl acetate or n-butyl alcohol, and carrying out reduced-pressure concentration to remove the ethyl acetate or n-butyl alcohol extractive of an organic solvent to obtain the extractive with the blood sugar reduction activity. In the method, two-time extraction is carried out on the alcohol extractive of costustoot by using the optimized organic extracting solvent so that a blood sugar reduction active site is purified, and components irrelevant to the blood sugar reduction activity are reduced or removed so that the purified product has stronger blood sugar reduction activity, exacter curative effect, higher safety, reduction of dosages required for an equivalent activity level and convenience for administration, can be used for preparing medicaments for preventing and curing diabetes mellitus, and has a favorable development and application prospect in the prevention and curing field of the diabetes mellitus.

Description

technical field [0001] The invention belongs to the technical field of extracting and purifying active parts of traditional Chinese medicines, and relates to the extraction and purification of active parts of chrysanthemum, in particular to the extraction and purification of active parts of chrysanthemum for lowering blood sugar. Background technique [0002] Diabetes is a major disease that threatens human health, and its growing epidemiological trend has constituted a serious public health problem. At present, the clinically used drugs for the treatment of type Ⅱ diabetes mainly include: (1) insulin and its analogues; (2) oral hypoglycemic agents: including biguanides, sulfonylureas, α-glucosidase inhibitors and insulin Sensitizers, etc. Western medicine is effective in treating diabetes, but there are certain side effects such as gastrointestinal reactions and liver and kidney damage, and the complications cannot be effectively controlled. The traditional Chinese medici...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61P3/10
Inventor 袁吕江李学刚金清邓亚飞
Owner SOUTHWEST UNIV
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