Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Cefcapene pivoxil hydrochloride composition and preparation method thereof

A technology of cefcapine hydrochloride and a composition, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, sugar-coated pills, etc., can solve the problems of difficult disintegration of cefcapine hydrochloride tablets, unqualified dissolution rate, etc.

Active Publication Date: 2011-08-03
CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD +1
View PDF3 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the cefcapene hydrochloride tablets prepared according to the composition of the above auxiliary materials still have disintegration difficulties, resulting in unqualified dissolution rate

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Cefcapene pivoxil hydrochloride composition and preparation method thereof
  • Cefcapene pivoxil hydrochloride composition and preparation method thereof
  • Cefcapene pivoxil hydrochloride composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] Embodiment 1: Cefcapene Pixil Hydrochloride Tablets

[0095] Prescription composition (1000 tablets) weight (g) weight percentage (%)

[0096] Cefcapene pivoxil hydrochloride 137 62.3

[0097] Starch 45.6 20.7

[0098] Sucrose 13.2 6

[0099] Croscarmellose sodium 11 5

[0100] Micronized silica gel 11 5

[0101] Magnesium stearate 2.2 1

[0102] Preparation method: first crush and sieve the cefcapene pivoxil hydrochloride raw material to control the particle size to be less than 80 μm, then mix the cefcapene pixil hydrochloride with the micropowder silica gel in the prescribed amount, add the starch, sucrose, and cross-linked carboxymethyl Sodium cellulose, mixed evenly, dry granulated, after granulation, add the prescribed amount of magnesium stearate, mixed evenly, compressed into tablets, coated with film.

[0103] Determination of dissolution: in 1000ml of buffered saline solution with a pH value of 6.8, the paddle method was used to determine the speed of ro...

Embodiment 2

[0104] Embodiment 2: Cefcapene Pixil Hydrochloride Tablets

[0105] Prescription composition (1000 tablets) weight (g) weight percentage (%)

[0106] Cefcapene pivoxil hydrochloride 137 62.3

[0107] Starch 45.6 20.7

[0108] Sucrose 13.2 6

[0109] Croscarmellose sodium 11 5

[0110] Micronized silica gel 11 5

[0111] 30% ethanol solution appropriate amount

[0112] Magnesium stearate 2.2 1

[0113] Preparation method: first crush and sieve the cefcapene pivoxil hydrochloride raw material to control the particle size to be less than 80 μm, then mix the cefcapene pixil hydrochloride with the micropowder silica gel in the prescribed amount, add the starch, sucrose, and cross-linked carboxymethyl Cellulose sodium, mix well, add appropriate amount of 30% ethanol solution, wet granulate, dry at 40°C, add prescription amount of magnesium stearate, mix well, compress into tablets, and coat with film.

[0114] Determination of dissolution: in 1000ml of buffered saline solutio...

Embodiment 3

[0115] Embodiment 3: Cefcapene Pixil Hydrochloride Tablets

[0116] Prescription composition (1000 tablets) weight (g) weight percentage (%)

[0117] Cefcapene pivoxil hydrochloride 137 62.3

[0118] Starch 34.6 15.7

[0119] Sucrose 13.2 6

[0120] Sodium carboxymethyl starch 22 10

[0121] Micronized silica gel 11 5

[0122] Magnesium stearate 2.2 1

[0123] Preparation method: first crush and sieve the cefcapene pivoxil hydrochloride raw material to control the particle size to be less than 80 μm, then mix the cefcapene pivoxil hydrochloride with micropowder silica gel in the prescribed amount, add starch, sucrose, and sodium carboxymethyl starch in the prescribed amount , mixed, dry granulated, after granulated, add the prescribed amount of magnesium stearate, mixed, pressed into tablets, film-coated.

[0124] Determination of dissolution: in 1000ml of buffered saline solution with a pH value of 6.8, the paddle method was used to determine the speed of rotation at 50 r...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention relates to a cefcapene pivoxil hydrochloride composition and a preparation method thereof. The composition comprises a tablet core and a coating layer, wherein the tablet core comprises cefcapene pivoxil hydrochloride, a filler, a disintegrating agent, an antisticking agent and a lubricating agent; the particle size of the raw material of cefcapene pivoxil hydrochloride is smaller than 100 microns; the antisticking agent accounts for 2%-10% in percentage by weight of the tablet core; the filter comprises a filler such as starch and the like and soluble auxiliary materials; and the soluble auxiliary materials accounts for 1%-10% in percentage by weight of the tablet core. The prepared cefcapene pivoxil hydrochloride tablet has good disintegration, and the dissolution of the cefcapene pivoxil hydrochloride tablet reaches over 75%.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a cefcapene hydrochloride composition and a preparation method thereof. Background technique [0002] Cefcapene pivoxil hydrochloride (cefcapene pivoxil hydrochloride), its chemical name is (6R, 7R)-7-[(Z)-2-(2-aminothiazol-4-yl)-2-pentenylamino]-3 -[(aminocarbonyl)oxy]methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (2,2-dimethyl Oxypropoxymethyl) ester hydrochloride monohydrate is an oral broad-spectrum antibiotic with valproyloxymethyl and stable to β-lactamase developed by Shionogi, Japan, in July 1997 It is listed in Japan under the trade name Flomox. It exerts antibacterial effect by blocking the synthesis of bacterial cell walls. It is mainly suitable for respiratory tract infections, otitis media, sinusitis, urinary tract infections, skin and skin tissue infections, and biliary tract infections caused by sensitive bacteria. Tablets are curren...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/546A61K9/28A61P31/04
Inventor 杜旭召白敏赫玉霞王蒙吴欢欢陈素锐
Owner CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com