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Methods for preparing collagen oleostock and moistening eyedrops

A technology of moisturizing eye solution and collagen, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, peptide/protein components, etc., can solve problems such as dry eye syndrome, drug resistance, irritation, etc., and achieve good curative effect and repair Effect of cornea, good biological activity

Active Publication Date: 2011-09-14
GUANGZHOU TRAUER BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, adding preservatives and / or antibiotics can cause side effects such as drug resistance and irritation, and severe cases may cause dry eye syndrome, glaucoma, etc.
[0006] In ophthalmic preparations, although collagen membranes have been widely used in eye injury treatment research, they are used in daily eye care and care products, and no mature products have yet been launched into the market

Method used

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  • Methods for preparing collagen oleostock and moistening eyedrops
  • Methods for preparing collagen oleostock and moistening eyedrops
  • Methods for preparing collagen oleostock and moistening eyedrops

Examples

Experimental program
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Effect test

preparation example Construction

[0030] A method for preparing a collagen stock solution, comprising the steps of:

[0031] 1) Soak the raw materials with bromogeramine solution, and then soak them in a mixed solution of peracetic acid and ethanol for disinfection and harmless treatment;

[0032] 2) Clean the sterilized and detoxified raw materials, and soak them in acetic acid solution for 12-48 hours to obtain a collagen stock solution.

[0033] Preferably, the concentration of the bromogeramine solution is 0.1-0.5%.

[0034] Preferably, the soaking time of the bromogeramine solution is 10-25 minutes.

[0035] Preferably, in the mixed solution of peracetic acid and ethanol, the volume concentration of peracetic acid is 0.1-0.3%, and the volume concentration of ethanol is 70-75%.

[0036] Preferably, the soaking time of the mixed solution of peracetic acid and ethanol is 10-30 minutes, more preferably, the soaking time is 10-20 minutes.

[0037] Preferably, the concentration of the acetic acid solution is...

Embodiment 1

[0052] 1) Wash the fresh rat tail with water to remove the serum and the stains and serum on the fur;

[0053] 2) Soak the cleaned rat tail in 0.5% bromogeramine solution for 15 minutes, and then soak it in 0.3% peracetic acid combined with 75% ethanol for 10 minutes;

[0054] 3) The rat tail was peeled and tendons extracted, cleaned, soaked in 0.05M acetic acid at low temperature for extraction for 48 hours, and the collagen stock solution was obtained.

Embodiment 2

[0056] 1) Wash the fresh rat tail with water to remove the serum and the stains and serum on the fur;

[0057] 2) Soak the cleaned rat tail in 0.1% bromogeramine solution for 25 minutes, then soak it in 0.1% peracetic acid combined with 70% ethanol for 20 minutes;

[0058] 3) The rat tail was peeled and tendons extracted, cleaned, soaked in 0.1M acetic acid at room temperature for extraction for 36 hours, and the collagen stock solution was obtained.

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Abstract

The invention discloses methods for preparing collagen oleostock and moistening eyedrops. The method for preparing collagen oleostok comprises the following steps of: soaking raw materials with bromogeramine; then soaking with the mixed solution of peracetic acid and ethanol for sterilizing and decontaminating; and cleaning the sterilized and decontaminated raw materials and soaking with acetum to obtain the collagen oleostock. The method for preparing moistening eyedrops comprises the following steps of: performing enzymolysis and purification on the collagen oleostock to obtain collagen liquid; adjusting the concentration and osmotic pressure of the collagen liquid, filling under an aseptic condition and finally sealing to obtain disposable moistening collagen eyedrops. By using the method for preparing the collagen oleostock, various microbes and harmful substances in the raw materials can be killed effectively, and collagen cannot be inactivated. The moistening eyedrops prepared by using the method disclosed by the invention has a good treatment effect on dry eye syndrome, can restore cornea, is applicable to eye ball cleaning, lubricating and moistening, routine nursing care on dry eye syndrome and hemostasis and restoration of cornea injury.

Description

technical field [0001] The invention relates to a preparation method of collagen stock solution and eye-moisturizing solution. Background technique [0002] Keratoconjunctival sicca, also known as dry eye, is a type of disease that causes ocular discomfort symptoms due to tear film instability and ocular surface damage caused by abnormal tear quality and quantity or tear fluid dynamics. Dry eye is the cause of many factors, among which, long-term use of eye lotion or care solution containing preservatives is one of the most important causes of eye dry eye syndrome in modern people. [0003] Adding a certain amount of preservatives to the eye lotion is good for the preservation of the preparation, but long-term use can cause superficial irritation or damage to the normal human eye cornea, thereby causing or aggravating dry eye symptoms. As a conventional preservative, brogeramine is widely used in various eye moisturizers, and the general dosage is 0.1g / ml. Some studies have...

Claims

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Application Information

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IPC IPC(8): A61K38/39A61K9/08A61P27/02
Inventor 雷静陈淡嫦林玉泉赵澎黄冬晶佟刚黄胜
Owner GUANGZHOU TRAUER BIOTECH
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