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Implant for treating glioblastoma and preparation method thereof

A technology of brain glioma and implants, which is applied in the field of implants for the treatment of brain cell tumors, can solve the problems of poor cure effect and high recurrence rate, and achieve the effect of reducing water absorption and good biocompatibility

Active Publication Date: 2011-10-12
HARBIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention aims to solve the defects of poor curative effect and high recurrence rate in existing glioblastoma treatment methods, and provides an implant for treating glioblastoma and its preparation method

Method used

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  • Implant for treating glioblastoma and preparation method thereof
  • Implant for treating glioblastoma and preparation method thereof
  • Implant for treating glioblastoma and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The implant used in the present embodiment for the treatment of glioblastoma is made of 34.4%~85.3% sebacic acid, 9.7%~15.6% glycerol and 5%~50% curcumin by mass percentage .

[0040] There are various structural formulas of polymers synthesized from sebacic acid and glycerol, one of which is

[0041]

[0042] However, the implant used in the treatment of glioblastoma in this embodiment is a cross-linked high molecular polymer elastomer, and its molecular structure is more complex and varied.

[0043] The implant used in this embodiment for the treatment of glioblastoma is a yellow to brown, transparent elastomer with an elastic strain of 10% to 500% at 35 to 37°C (measured with a BE120-2CA / 3CA strain gauge) , The tensile strength is 0.1 ~ 5MPa.

[0044] The higher the curcumin content, the darker the color of the implant used to treat glioblastoma.

[0045] The higher curcumin content in the implant for the treatment of glioblastoma in this embodiment, the hydrop...

Embodiment 2

[0047] The implant used for the treatment of glioblastoma in this embodiment is made of 41.2%-80.8% sebacic acid, 10.2%-14.8% glycerol and 9%-44% curcumin by mass percentage.

Embodiment 3

[0049] The implant used for treating glioblastoma in this example is made of 83% sebacic acid, 12% glycerin and 5% curcumin by mass percentage.

[0050] The implant used for treating glioblastoma in this example was soaked in physiological saline for 1 day, and the mass only increased by 0.5%, but the volume did not increase.

[0051] This embodiment is used to treat the implant of brain glioblastoma such asfigure 1 As shown, the released amount is as image 3 "●" curve in the middle.

[0052] The infrared spectrum of the implant used in the treatment of glioblastoma in this embodiment is as follows: Figure 4 Shown in curve C1.

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Abstract

The invention provides an implant for treating glioblastoma and a preparation method thereof, relating to an implant for treating brain cytoma and a preparation method thereof. The implant for treating the glioblastoma is prepared from the following components in percentage by mass: 34.4 to 85.3 percent of sebacic acid, 9.7 to 15.6 percent of glycerol, and 5 to 50 percent of curcuma. The preparation method comprises the following steps: 1, preparing an implant semi-finished product; and 2, drying in vacuum. The implant for treating the glioblastoma is a cross-linked high molecular polymer elastomer, has a complex molecular structure and large relative molecular weight, and can be used in treatment of the glioblastoma.

Description

technical field [0001] The invention relates to an implant for treating brain cell tumors and a preparation method thereof. Background technique [0002] Glioblastoma mainly occurs in the brain and is a kind of central tumor with serious harm. The existing treatment methods for glioblastoma mainly adopt surgical resection, postoperative radiotherapy and chemotherapy. However, there are obvious defects in the above treatment methods: [0003] Surgical resection, surgical resection mainly achieves the purpose of reducing the number of glioma cells, relieving tumor-bearing symptoms, and temporarily reducing intracranial pressure. Tumor recurrence due to escalation of malignancy; moreover, glioblastoma infiltrates and grows and cannot be completely removed by surgery; [0004] Postoperative radiation therapy can effectively kill glioma cells only when the radiation dose reaches 73-80Gy, while the dose that normal brain tissue can tolerate is only 60Gy, so in order to protect ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/12A61K9/00A61K47/34A61P35/00A61P25/00
Inventor 董德利孙志洁杨宝峰
Owner HARBIN MEDICAL UNIVERSITY