Carboxymethyl hydroxyethyl modified cotton fiber hemostyptic fabric and preparation method thereof

A carboxymethyl hydroxyethyl, cotton fiber fabric technology, applied in the field of polymer chemistry, can solve problems such as inconvenient operation, and achieve the effect of eliminating coagulation or poor absorption

Inactive Publication Date: 2011-10-19
郑明义
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] 2. Non-ionic cellulose ethers containing neutral substituent groups are found in clinical applications. Due to their strong hydrophilicity and fast dissolution speed, they often cause inconvenience in operation.

Method used

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  • Carboxymethyl hydroxyethyl modified cotton fiber hemostyptic fabric and preparation method thereof
  • Carboxymethyl hydroxyethyl modified cotton fiber hemostyptic fabric and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Put 20.5 g of pure cotton degreasing gauze in 20% NaOH aqueous solution, basify for 2 hours at a temperature of t=18° C., and centrifugally deliquify until the weight of the gauze containing lye is 36.9 g. Arrange the alkalized yarn in a reactor, add 400ml of 95% isopropanol, vacuumize to -0.08Mpa, inhale 18.6ml of ethylene oxide several times, and react at 20-25°C for 10 hours. Then add 20.5 g of monochloroacetic acid, stir to dissolve, add 21.6 ml of 40% NaOH aqueous solution at the same time, continue to stir and react for 10 hours, and the reaction temperature t=20~30°C. After the reaction, adjust the pH to 7.1 with hydrochloric acid, and then wash the gauze with 80% isopropanol until the gauze contains NaCl below 1%. Finally, the yarn is dried in a drying oven at a drying temperature of <80°C. Obtain 33.5 g of carboxymethyl hydroxyethyl modified cotton fiber gauze.

Embodiment 2

[0028] Pure cotton degreasing gauze 26.5g, put in 25% NaOH aqueous solution, alkalization temperature t=20 ℃, time 1 hour. Centrifuge and deliquify until the gauze containing lye weighs 53g. Arrange the alkalized yarn in the reactor, add 450ml of 95% isopropanol, vacuumize to -0.08Mpa, add 30ml of ethylene oxide in several times, the reaction temperature is 25°C, and the reaction time is 8 hours. Then 15.9 g of monochloroacetic acid was added, stirred to dissolve, and 16.7 ml of 40% NaOH aqueous solution was added at the same time, and reacted at 20-25° C. for 12 hours. Then adjust the pH to 7 with hydrochloric acid, and wash the gauze with 80% isopropanol until the NaCl content in the gauze is below 1%. Finally, place the yarn in a drying oven to dry at 65°C. Obtain carboxymethyl hydroxyethyl modified cotton fiber gauze 46.7g.

[0029] Tests have confirmed that the average hemostatic time for carboxymethyl hydroxyethyl modified cotton fiber hemostatic fabric on surgical wo...

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Abstract

The invention provides a carboxymethyl hydroxyethyl modified cotton fiber hemostyptic fabric and a preparation method thereof. The preparation method comprises the following steps of: alkalifying a pure cotton fabric by using a NaOH solution; reacting with ethylene oxide to complete the modification of ethoxy; and reacting with monochloro acetic acid to obtain the carboxymethyl hydroxyethyl modified cotton fiber hemostyptic fabric. Animal experiments prove that: when the fabric is used for medical hemostasis, the hemostyptic time is shorter than 2 minutes averagely, the in-vivo complete absorption time is 15 to 20 days, and residue is avoided.

Description

technical field [0001] The invention relates to a carboxymethyl hydroxyethyl modified cotton fiber hemostatic fabric and a preparation method thereof, belonging to the field of polymer chemistry. Background technique [0002] At present, a variety of absorbent modified cotton fiber fabrics have been used for medical hemostasis at home and abroad. These hemostatic fabrics are all made by introducing hydrophilic groups into cellulose by chemical modification. A number of patents or papers have been published at home and abroad. These existing absorbent cotton fiber hemostatic fabrics can be divided into two categories: ionic cellulose ethers containing acidic substituent groups (such as oxidized cellulose, carboxymethyl cellulose, etc.) and ionic cellulose ethers containing neutral substituent groups. Non-ionic cellulose ether (such as hydroxyethyl cellulose, etc.). These two types of hemostatic fabrics have achieved good results in clinical applications, but there are also...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/22D06M13/11D06M13/188D06M101/06
Inventor 郑明义
Owner 郑明义
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