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Hyperbranched star polylactic acid-poly(2-methacryloyloxyethyl phosphorylcholine) block polymer nanoparticle prepared by volatilization method and method

A technology of methacryloyloxyethylphosphorylcholine and block polymer, which is applied in the preparation of hyperbranched star-shaped polylactic acid-poly 2-methacryloyloxyethylphosphorylcholine block by volatilization method Segment of polymer nanoparticles and fields, to achieve the effect of low critical micelle concentration and good dispersion

Inactive Publication Date: 2011-11-02
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation of nanoparticles using hyperbranched star block polymers has not been introduced yet.

Method used

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  • Hyperbranched star polylactic acid-poly(2-methacryloyloxyethyl phosphorylcholine) block polymer nanoparticle prepared by volatilization method and method
  • Hyperbranched star polylactic acid-poly(2-methacryloyloxyethyl phosphorylcholine) block polymer nanoparticle prepared by volatilization method and method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] 1. Take 0.01 mg of hyperbranched star-shaped SPLA-b-PMPC polymer in a small test tube, add 1 ml of acetone / water (1:0.1 by volume) mixed solvent into each test tube, shake gently to slowly disperse the polymer. Add 1ml of deionized water and a magnetic stirrer of appropriate size to a 25ml beaker, start stirring and adjust the speed, draw the acetone-water solution of SPLA-b-PMPC with a disposable syringe, inject it into the beaker at one time, and then evaporate the solvent at room temperature , get the product. attached figure 1 It is a transmission electron microscope picture of the obtained nanoparticles, and the particle diameter is about 50-80nm.

[0016] 2. Using the fluorescence spectrum of the pyrene probe to study CAC: measure the excitation spectrum of pyrene in different concentrations of hyperbranched star-shaped SPLA-b-PMPC polymer aqueous solution, it can be seen that the fluorescence intensity increases with the increase of the polymer concentration. W...

Embodiment 2

[0018] 1. Take 100 mg of hyperbranched star-shaped SPLA-b-PMPC polymer in a small test tube, add 10 ml of acetone / water (1:10 by volume) mixed solvent into each test tube, shake gently to slowly disperse the polymer. Add 100ml of deionized water and a magnetic stirrer of appropriate size to a 25ml beaker, start stirring and adjust the speed, draw the acetone-water solution of SPLA-b-PMPC with a disposable syringe, inject it into the beaker at one time, and then evaporate the solvent at room temperature , get the product. attached figure 1 It is a transmission electron microscope picture of the obtained nanoparticles, and the particle diameter is about 50-80nm.

[0019] 2. Study CAC with the fluorescence spectrum of the pyrene probe: measure the excitation spectrum of pyrene in different concentrations of hyperbranched star-shaped SPLA-b-PMPC polymer aqueous solution, it can be seen that the fluorescence intensity increases with the increase of the polymer concentration. When...

Embodiment 3

[0021] 1. Take 10 mg of hyperbranched star-shaped SPLA-b-PMPC polymer in a small test tube, add 2 ml of acetone / water (1:1 by volume) mixed solvent into each test tube, shake gently to slowly disperse the polymer. Add 9ml of deionized water and a magnetic stirrer of appropriate size to a 25ml beaker, start stirring and adjust the speed, draw the acetone-water solution of SPLA-b-PMPC with a disposable syringe, inject it into the beaker at one time, and then evaporate the solvent at room temperature , get the product. attached figure 1 It is a transmission electron microscope picture of the obtained nanoparticles, and the particle diameter is about 50-80nm.

[0022] 2. Using the fluorescence spectrum of the pyrene probe to study CAC: measure the excitation spectrum of pyrene in different concentrations of hyperbranched star-shaped SPLA-b-PMPC polymer aqueous solution, it can be seen that the fluorescence intensity increases with the increase of the polymer concentration. When ...

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Abstract

The invention relates to a hyperbranched star polylactic acid-poly(2-methacryloyloxyethyl phosphorylcholine) block polymer nanoparticle prepared by a volatilization method and a method. The method comprises the following steps: adding 0.01 to 100mg of hyperbranched star polylactic acid-poly(2-methacryloyloxyethyl phosphorylcholine) block polymer into a test tube, and adding 1 to 10ml of acetone / water mixed solvent into the test tube, wherein the volume ratio of the acetone to the water is 1:(0.1-10); adding 1 to 100ml of deionized water and a magnetic stir bar into a beaker, stirring, sucking the previously prepared acetone-aqueous solution of SPLA-b-PMPC by use of a disposable injector, and injecting into the beaker once; and volatizing the solvent at normal temperature to obtain the product. The nanoparticles are structurally spherical and uniformly dispersed, and have the particle diameter from 50 to 80nm and the critical micelle concentration from 9.94*10<-4> mg / ml.

Description

technical field [0001] The invention relates to a volatilization method for preparing hyperbranched star-shaped polylactic acid-poly 2-methacryloyloxyethyl phosphorylcholine block polymer nanoparticles and a method. Background technique [0002] Nanoparticles are attracting increasing interest in the field of medicine because of their ability to achieve optimal dosage ranges of drug concentrations, thereby leading to increased therapeutic efficacy and fewer side effects, thereby reducing patient suffering. Chemotherapeutic drugs can be covalently coupled to the particle surface, or dispersed in the nanoparticle, or coated on the core of the nanoparticle. By designing the delivery system, the drug can be released in a controlled or triggered manner. Nanoparticle surfaces can be functionalized in a number of ways to increase their residence time in blood and reduce off-target distribution. For example, the hydrophilic polymer polyethylene glycol, grafted, conjugated or adsor...

Claims

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Application Information

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IPC IPC(8): C08L53/00C08J3/12
Inventor 亓洪昭马桂秋何立刚盛京原续波
Owner TIANJIN UNIV
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